21683-86-3

Usage

Uses

Used in Pharmaceutical Industry:
3-(1-BENZOFURAN-2-YL)PROPANOIC ACID is used as a starting material for the synthesis of various drugs and pharmaceutical products, leveraging its chemical structure to create new therapeutic agents.
Used in Anti-inflammatory and Analgesic Applications:
3-(1-BENZOFURAN-2-YL)PROPANOIC ACID is used as an anti-inflammatory and analgesic agent, due to its inherent properties that can help in the development of new therapeutic agents for pain relief and reducing inflammation.
Used in Neurodegenerative Disease Treatment:
3-(1-BENZOFURAN-2-YL)PROPANOIC ACID is used as a potential treatment for neurodegenerative diseases, as it has shown promising effects in protecting neuronal cells from oxidative stress and inflammation, which are common pathological features in such conditions.

InChI:InChI=1/C11H10O3/c12-11(13)6-5-9-7-8-3-1-2-4-10(8)14-9/h1-4,7H,5-6H2,(H,12,13)/p-1

Upstream product

• 3199-61-9 ethyl coumarilate 
• 7522-79-4 2-vinylbenzofuran 
• 124-38-9 carbon dioxide 
• 4265-16-1 2-formylbenzo[b]furan 
• 546084-15-5 methyl 3-(benzofuran-2-yl)propanoate 
• 256439-83-5 (2E)-methyl 3-(2-benzofuranyl)propenoate 
• 76268-18-3 C₁₆H₁₄N₂O₄S 
• 42974-19-6 benzo[b]furan-2-carbohydrazide 
• 132376-67-1 (2E)-3-(1-benzofuran-2-yl)-2-propenoic acid 

Downstream Products

• 401613-20-5 3-benzofuran-2-yl-N-[1-(3,4-dichlorobenzyl)piperidin-4-yl]propionamide 
• 1373038-08-4 C₂₄H₂₂F₃NO₄ 
• 1373038-18-6 C₂₄H₂₂F₃NO₄ 
• 1373037-80-9 (S)-3-(3-(benzofuran-2-yl)propanoyl)-4-benzyl-5,5-dimethyloxazolidin-2-one 

Relevant academic research and scientific papers

Direct β-Selective Hydrocarboxylation of Styrenes with CO2 Enabled by Continuous Flow Photoredox Catalysis

The direct β-selective hydrocarboxylation of styrenes under atmospheric pressure of CO2 has been developed using photoredox catalysis in continuous flow. The scope of this methodology was demonstrated with a range of functionalized terminal styrenes, as well as α-substituted and β-substituted styrenes.

Palladium-Catalyzed Dearomatizing Difunctionalization of Indoles and Benzofurans

A palladium-catalyzed dearomatizing difunctionalization of N-Boc-indoles and benzofurans to give tricyclic indolines and 2,3-dihydrobenzofurans with a fully substituted carbon center is described. Product formation occurs under mild conditions at room temperature with commercially available aryl boronic acids and 2,2,6,6-tetramethylpiperidine-1-oxyl (TEMPO) as a mild oxidant in good yields. 2-Carboxyalkyl-substituted indoles and benzofurans react under Pd-catalysis with aryl boronic acids and TEMPO through dearomatizing arylation/cyclization to the corresponding indolines and dihydrobenzofurans containing a lactone moiety bearing a fully substituted carbon center.

A simple method for asymmetric trifluoromethylation of N-acyl oxazolidinones via Ru-catalyzed radical addition to zirconium enolates

A Ru-catalyzed direct thermal trifluoromethylation and perfluoroalkylation of N-acyloxazolidinones has been developed. The reaction is experimentally simple and requires inexpensive reagents while providing good yields of products with good levels of stereocontrol. Preliminary studies have shown notable compatibility with functional groups, aromatics, and certain heteroaromatic substituents. The described method provides a useful alternative for the synthesis of fluorinated materials in an experimentally convenient manner.

Syntheses of Furano Compounds: Part XLIV. Syntheses of 2-CarboxybenzoFuran-3-Acetic Acid and 3-CarboxybenzoFuran-2-Acetic Acid

1-Carboxybenzofuran-3-acetic acid and 3-carboxybenzofuran-acetic acid have been synthesised. A new synthesis of benzofuran-3-acetic acid, a plant hormone is reported.