- Improved activity of horseradish peroxidase (HRP) in 'specifically designed' ionic liquid
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The ionic liquid (IL), tetrakis (2-hydroxyethyl) ammonium triflouromethanesulfonate is rationally designed for horseradish peroxidase (HRP) on the basis of its stability and activity in the presence of an excipient, tris(hydroxymethyl)aminoethane (TRIS) in different ILs. The activity of HRP in this tailor made IL is at least 30-240-fold higher than that in conventional ILs. Also, the activity is more than 10 times greater than that in methanol, a common organic solvent used for HRP.
- Das, Dibyendu,Dasgupta, Antara,Das, Prasanta Kumar
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- A class of quaternary ammonium biocompatible ionic liquid, preparation method and use thereof
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The invention discloses a quaternary ammonium type biological compatible ionic liquid as well as a preparation method and an application thereof. The quaternary ammonium type biological compatible ionic liquid has the following general formula (described in the specification). The invention also discloses the preparation method of the compound. The quaternary ammonium type biological compatible ionic liquid has good biological compatibility; a preparation technology is simple and convenient, raw materials are cheap and available, requirements on production equipment and the environment are low, product purity is high, yield is high, the quaternary ammonium type biological compatible ionic liquid is especially applicable to large-scale industrial production, and important significance on increase of production capacity of the biochemical industry and the western medicine preparation industry and improvement of competitiveness of the biochemical industry and the western medicine preparation industry can be realized. The general formula is as follows: [(HOCH2CH2)3N(CH2)mOH][HO(CH2)nSO3][TEACmOH][HOCnSO3], wherein m is 2-4, and n is 1-3.
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Paragraph 0042-0043
(2017/08/25)
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