132776-22-8 Usage
Chemical class
Pyrimidine analog
Structural similarity
Nucleoside analogs
Potential applications
Antiviral and antineoplastic properties
Target diseases
Viral infections (e.g., HIV) and certain types of cancer
Mechanism of action
Interferes with viral DNA and RNA replication, inhibits cancer cell growth
Current status
Studied for potential therapeutic use, more research needed
Compound structure
1-[2,3-dideoxy-2,3-difluoro-5-O-(phenylcarbonyl)-beta-D-arabinofuranosyl]-5-methyl-4-thioxo-3,4-dihydropyrimidin-2(1H)-one
Check Digit Verification of cas no
The CAS Registry Mumber 132776-22-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,3,2,7,7 and 6 respectively; the second part has 2 digits, 2 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 132776-22:
(8*1)+(7*3)+(6*2)+(5*7)+(4*7)+(3*6)+(2*2)+(1*2)=128
128 % 10 = 8
So 132776-22-8 is a valid CAS Registry Number.
132776-22-8Relevant articles and documents
Fluorinated sugar analogues of potential anti-HIV-1 nucleosides
Huang,Chen,Wang,Kim,Warshaw,Armstrong,Zhu,Chou,Watanabe,Matulic-Adamic,Su,Fox,Polsky,Baron,Gold,Hardy,Zuckerman
, p. 1640 - 1646 (2007/10/02)
In order to obtain agents with therapeutic indices superior to those of AZT, FLT, or D4T, several analogues of anti-HIV-1 nucleosides were synthesized. These include 2',3'-dideoxy-2',3'-difluoro-5-methyluridine (13), its arabino analogue 19, arabino-5-met