133044-31-2Relevant articles and documents
Vibrational spectroscopy investigation using ab initio and density functional theory analysis on the structure of 3-(6-benzoyl-2-oxobenzo[d]oxazol-3(2H)-yl)propanoic acid
Arslan, Hakan,Alguel, Oeztekin,Oenkol, Tijen
, p. 606 - 614 (2008)
The molecular structure, vibrational frequencies and infrared intensities of the 3-(6-benzoyl-2-oxobenzo[d]oxazol-3(2H)-yl)propanoic acid were calculated by the HF and DFT methods using 6-31G(d) basis set. The FT-infrared spectra have been measured for th
Benzazoles. 1. Acylation of benzothiazolin-2-ones by aromatic acid chlorides using small amounts of zinc chloride
Mukhamedov,Dushamov,Aliev,Bobokulov,Levkovich,Abdullaev
, p. 344 - 348 (2002)
We show that the yield of 6-aroylbenzothiazolin-2-ones, products of acylation of benzothiazolin-2-ones by aromatic acid chlorides in the presence of ZnCl2, depends on the degree of nucleophilicity of benzothiazolin-2-ones.
Study of the acylation reaction of 2(3H)-benzothiazolones in the mixture of ZnCl2-DMF
Guenadil, Faouzi,Aichaoui, Houcine
, p. 2633 - 2638 (2002)
The use of polyphosphoric acid and the complex AlCl3-DMF in 6-acylation of 2(3H)-benzothiazolones previously have been reported. Instead of the frequently used AlCl3 as a catalyst in the Friedl-Crafts reactions, we conducted the acyl
Benzoylation of 2(3H)-benzothiazolones in the presence of 8 equivalents of zinc chloride in N,N-dimethylformamide
Guenadil, Faouzi,Aichaoui, Houcine,Liacha, Messaoud
, p. 755 - 757 (2002)
The use of the mixture of aluminum chloride-N,N-dimethylformamide1,2 (AlCl3-DMF, 11:1) reagent in the Friedl-Crafts C acylation reaction of 2(3H)-benzothiazolones was previously reported3. These acylations reactions were f
FeCl3-DMF complex as efficient catalyst for the synthesis of 6-acyl-2(3H)-benzoxazolones and 6-acyl-2(3H)-benzothiazolones
Guenadil, Faouzi
, p. 579 - 585 (2019)
FeCl3-DMF complex has been tested on Friedel-Crafts reaction of 2(3H)-benzoxazolone and 2(3H)-benzothiazolone with acid chlorides and anhydrides as acylating agents. In these conditions, the 6-acyl-2(3H)-benzoxazolones and 6-acyl-2(3H)-benzothiazolones were obtained in yields ranging from 52 to 89%. Among the various commonly catalysts; AlCl3-DMF, ZnCl2-DMF and PPA, explored in this study, the best conditions using FeCl3-DMF were found the most convenient one
Benzazoles. 2. Relative activity of catalysts and 4-substituted benzoyl chlorides in the acylation of benzothiazolin-2-ones
Dushamov,Mukhamedov,Aliev,Bobokulov,Levkovich,Abdullaev
, p. 438 - 441 (2002)
A series has been established for the relative activity of catalysts and 4-substituted benzoyl chlorides on acylation of benzothiazolin-2-ones with 4-substituted benzoyl chlorides in the presence of FeCl3, FeCl3·6H2O, FeCl3·12H2O, ZnCl2, ZnCl2·2H2O, AlCl3, and iron acetylacetonate, as a function of the degree of acidity of the catalyst and the electrophilicity of the acylating agent.
Design and synthesis of 3-acyl-2(3H)-benzoxazolone and 3-acyl-2(3H)- benzothiazolone derivatives
Guenadil, Faouzi,Aichaoui, Hocine,Kapanda, Coco N.,Lambert, Didier M.,McCurdy, Christopher R.,Poupaert, Jacques H.
experimental part, p. 67 - 80 (2011/09/20)
A simpler and efficient "green" method using solid sodium hydroxide in a solvent mixture of acetone/water was found to catalyze N-acylation of 2(3H)-benzoxazolones and 2(3H)-benzothiazolones for facile and rapid synthesis of N-acyl derivatives in excellent yields. This method was applied to the synthesis of a series of 132 compounds employing a variety of acyl chlorides. Graphical abstract: [Figure not available: see fulltext.]
Amide derivatives of [6-acyl-2-benzothiazolinon-3-yl] acetic acids as potential analgesic and anti-inflammatory compounds
Oenkol, Tijen,Banoglu, Erden,Duendar, Yasemin,Kuepeli, Esra,Sahin, M. Fethi
scheme or table, p. 11 - 24 (2010/10/20)
In this study, we investigated the analgesic and anti-inflammatory activities of [6-acyl-2-benzothiazolinon-3-yl]acetic acids by the derivatization of the carboxylate moiety into amides. We have tested the analgesic and anti-inflammatory activities of the synthesized compounds in vivo by using p-benzoquinone-induced writhing test and carrageenan-induced hind paw edema model, respectively. Compounds 4h, 4i, 4n, and 4o showed comparable analgesic and anti-inflammatory activities to the references without gastric lesions in the tested animals. In addition, all compounds also tested for their inhibitory activity against cyclooxygenase (COX)-1, COX-2 and 5-lipoxygenase (LOX), but no significant inhibition was observed under assayed conditions.
Microwave synthesis and antimicrobial evaluation of Mannich bases of 6-benzoyl-2(3H)-benzothiazolone
Ciba, Melda,Kaynak, Fatma,Ozgen, Selda,Sahin, M. Fethi,Onkol, Tijen
experimental part, p. 5685 - 5693 (2012/07/28)
In this study, new eight Mannich base of 6-benzoyl-2(3H)-benzothiazolone derivatives have been synthesized in microwave irradiation. Structures of the synthesized compounds have been elucidated by IR and 1H NMR spectral data and their elemental analyses. The in vitro antimicrobial activity of the compounds was determined against some gram positive, gram negative bacteria, fungi and their drug-resistant isolates in comparison with reference drugs. All the compounds were also screened for their antimycobacterial activity against Mycobacterium tuberculosis H37RV by using the microplate alamar blue assay (MABA) method.
Aromatase inhibitor compounds and uses thereof
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Page/Page column 4, (2010/11/26)
The invention concerns the use of a compound of formula (I) inhibitor of aromatase for the preparation of a pharmaceutical formulation intended for treatment of cancer or psoriasis. It equally relates to compounds of formula (I), notably for their use as active ingredients of a medication.
