22300-56-7

Usage

Uses

Used in Pharmaceutical Industry:
4-Methyl-2-phenyl-1,2,3-triazole-5-carboxylic acid is used as a chemical intermediate for the synthesis of pharmaceutical compounds. Its unique structure with methyl and phenyl groups allows for specific reactivity and interactions with other molecules, which can be harnessed to develop new drugs or improve existing ones.
Used in Agrochemical Industry:
In the agrochemical sector, 4-Methyl-2-phenyl-1,2,3-triazole-5-carboxylic acid is used as a building block for the creation of agrochemical products. Its properties may contribute to the development of new pesticides, herbicides, or other agricultural chemicals that can enhance crop protection and yield.
Used in Chemical Research:
4-Methyl-2-phenyl-1,2,3-triazole-5-carboxylic acid is employed as a research compound in academic and industrial laboratories. Its involvement in various chemical reactions provides insights into the behavior of triazoles and their potential applications in the synthesis of new materials or the discovery of novel chemical reactions.

InChI:InChI=1/C10H9N3O2/c1-7-9(10(14)15)12-13(11-7)8-5-3-2-4-6-8/h2-6H,1H3,(H,14,15)/p-1

Upstream product

• 618-40-6 1-Methyl-1-phenylhydrazine 
• 5408-04-8 ethyl 2-hydroxyimino-3-oxobutanoate 
• 6030-06-4 2-hydroxyimino-3-phenylhydrazono-butyric acid anilide 
• 7673-93-0 methyl 5-methyl-2-phenyl-2H-1,2,3-triazole-4-carboxylate 
• 187455-83-0 4-Carboxy-5-methyl-2-phenyl-1,2,3-triazole-1-oxide 
• 187455-79-4 4-Methyl-2-phenyl-5-ethoxycarbonyl-1,2,3-triazole-3-oxide 
• 62947-11-9 4,4-Dibromo-3-methyl-1-phenyl-2-pyrazolin-5-one 
• 61145-28-6 4,4-diazido-3-methyl-1-phenyl-1H-pyrazol-5(4H)-one 
• 89-25-8 edaravone 
• 369-57-3 benzenediazonium tetrafluoroborate 

Downstream Products

• 36401-55-5 5-methyl-2-phenyl-2H-1,2,3-triazole-4-carboxyl chloride 
• 380606-74-6 6-carbamoyl-4S-[(5-methyl-2-phenyl-2H-[1,2,3]triazole-4-carbonyl)-amino]-hex-2-enoic Acid Ethyl Ester 
• 13322-19-5 (5-methyl-2-phenyl-2H-1,2,3-triazol-4-yl) methanol 
• 1074764-07-0 tert-butyl (2-methyl-2-{[(3S)-3-{[(5-methyl-2-phenyl-2H-1,2,3-triazol-4-yl)carbonyl]amino}-3,4-dihydro-2H-chromen-5-yl]oxy}propyl)carbamate 
• 1074763-05-5 5-methyl-N-((2R)-8-[(1-methylpiperidin-4-yl)oxy]-1,2,3,4-tetrahydronaphthalen-2-yl)-2-phenyl-2H-1,2,3-triazole-4-carboxamide 
• 1083418-57-8 5-methyl-2-phenyl-2H-[1,2,3]triazole-4-carboxylic acid [5-chloro-2-(1H-tetrazol-5-yl)-phenyl]-amide 
• 1133430-85-9 5-methyl-2-phenyl-2H-[1,2,3]triazole-4-carboxylic acid (1-ethyl-3-oxo-2,3-dihydro-1H-indazol-5-yl)-amide 
• 945856-56-4 C₁₄H₁₁N₇OS 
• 1074764-36-5 5-methyl-N-[(3S)-5-(4-methylpiperazin-1-yl)-3,4-dihydro-2H-chromen-3-yl]-2-phenyl-2H-1,2,3-triazole-4-carboxamide 
• 1072852-64-2 5-methyl-2-phenyl-N-[(3S)-5-pyridin-4-yl-3,4-dihydro-2H-chromen-3-yl]-2H-1,2,3-triazole-4-carboxamide 
• 51039-50-0 5-methyl-2-phenyl-2H-[1,2,3]triazole 

Relevant academic research and scientific papers

Cu-Mediated Expeditious Annulation of Alkyl 3-Aminoacrylates with Aryldiazonium Salts: Access to Alkyl N2-Aryl 1,2,3-Triazole-carboxylates for Druglike Molecular Synthesis

Alkyl N-aryl 1,2,3-triazole-carboxylates are important molecules or intermediates in medicinal chemistry, but the synthesis of N2-aryl counterparts remains elusive. Herein, we describe a Cu-mediated annulation reaction of alkyl 3-aminoacrylates with aryldiazonium salts, both of which are readily available substrates. Furthermore, alkyl 2-aminoacrylates are also viable substrates. Diverse alkyl N2-aryl 1,2,3-triazole-carboxylates and their analogues can be rapidly prepared under mild conditions. Especially, this protocol allows one to access several druglike variants of carbonic anhydrase inhibitors and celecoxib.

1,2,3-Triazole N-Oxides. II. Synthesis of Substituted 4(5)-Ethoxycarbonyl-1,2,3-triazole N-Oxides

Oxidative cyclization of ethyl 2-hydrazono-3-hydroxyimino- and 3-hydrazono-2-hydroxyiminobutanoates in the presence of γ-MnO2 yields isomeric 4(5)-methyl-2-phenyl-5(4)-ethoxycarbonyl-1,2,3-triazole 1-oxides. Alkaline hydrolysis and ammonolysis

Methylation of 3-Methyl- and 3-Phenyl-4-arylhydrazonoisoxazol-5-ones with Diazomethane

3-Methyl(or phenyl)-4-arylhydrazonoisoxazol-5-ones on methylation with diazomethane afford 3-methyl(or phenyl)-4-(N-methylarylhydrazono)isoxazol-5-ones and 3-methyl(or phenyl)-5-methoxy-4-arylhydrazonoisoxazoles.The latter compounds readily rearrange to 4