22300-56-7

Basic information

• Product Name: 4-METHYL-2-PHENYL-1,2,3-TRIAZOLE-5-CARBOXYLIC ACID
• Synonyms: TIMTEC-BB SBB005431;5-METHYL-2-PHENYL-2H-1,2,3-TRIAZOLE-4-CARBOXYLIC ACID;4-METHYL-2-PHENYL-1,2,3-TRIAZOLE-5-CARBOXYLIC ACID;BUTTPARK 37\06-88
• CAS NO: 22300-56-7
• Molecular Formula: C₁₀H₉N₃O₂
• Molecular Weight: 203.2
• Product Categories: Triazole Derivatives
• Mol File: 22300-56-7.mol
• Article Data: 4

Chemical Properties

• Melting Point: 200-202°C
• Boiling Point: 432.9°C at 760 mmHg
• Flash Point: 215.6°C
• Appearance: /
• Vapor Pressure: 2.91E-08mmHg at 25°C
• BRN: 177649
• CAS DataBase Reference: 4-METHYL-2-PHENYL-1,2,3-TRIAZOLE-5-CARBOXYLIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 4-METHYL-2-PHENYL-1,2,3-TRIAZOLE-5-CARBOXYLIC ACID(22300-56-7)
• EPA Substance Registry System: 4-METHYL-2-PHENYL-1,2,3-TRIAZOLE-5-CARBOXYLIC ACID(22300-56-7)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36/37/39
• Hazardous Substances Data: 22300-56-7(Hazardous Substances Data)

Usage

General Description

4-Methyl-2-phenyl-1,2,3-triazole-5-carboxylic acid is a specific compound belonging to the classification of chemicals known as triazoles. Triazoles are nitrogen-containing rings that are often used in pharmaceuticals and agrochemicals. The presence of both methyl and phenyl groups in 4-Methyl-2-phenyl-1,2,3-triazole-5-carboxylic acid indicate variations in the basic triazole structure, which can influence the properties and reactivity of the compound. This particular chemical may be involved in various chemical reactions and could be part of more complex chemical compounds. However, its specific uses or properties are not commonly highlighted in generalized chemical literature, suggesting that it is more likely to be used in specific, possibly specialized, chemical contexts.

InChI:InChI=1/C10H9N3O2/c1-7-9(10(14)15)12-13(11-7)8-5-3-2-4-6-8/h2-6H,1H3,(H,14,15)/p-1

Upstream product

• 369-57-3 benzenediazonium tetrafluoroborate 
• 89-25-8 edaravone 
• 61145-28-6 4,4-diazido-3-methyl-1-phenyl-1H-pyrazol-5(4H)-one 
• 62947-11-9 4,4-Dibromo-3-methyl-1-phenyl-2-pyrazolin-5-one 
• 187455-79-4 4-Methyl-2-phenyl-5-ethoxycarbonyl-1,2,3-triazole-3-oxide 
• 187455-83-0 4-Carboxy-5-methyl-2-phenyl-1,2,3-triazole-1-oxide 
• 7673-93-0 methyl 5-methyl-2-phenyl-2H-1,2,3-triazole-4-carboxylate 
• 6030-06-4 2-hydroxyimino-3-phenylhydrazono-butyric acid anilide 
• 618-40-6 1-Methyl-1-phenylhydrazine 
• 5408-04-8 ethyl 2-hydroxyimino-3-oxobutanoate 

Downstream Products

• 945856-56-4 C₁₄H₁₁N₇OS 
• 1074764-36-5 5-methyl-N-[(3S)-5-(4-methylpiperazin-1-yl)-3,4-dihydro-2H-chromen-3-yl]-2-phenyl-2H-1,2,3-triazole-4-carboxamide 
• 1072852-64-2 5-methyl-2-phenyl-N-[(3S)-5-pyridin-4-yl-3,4-dihydro-2H-chromen-3-yl]-2H-1,2,3-triazole-4-carboxamide 
• 51039-50-0 5-methyl-2-phenyl-2H-[1,2,3]triazole 
• 241798-02-7 5-(N,N-dimethylcarbamoyl)-2-phenyl-2H-1,2,3-triazole-4-carboxylic acid 
• 22300-57-8 2-phenyl-1,2,3-triazole-4,5-dicarboxylic acid 
• 36401-55-5 5-methyl-2-phenyl-2H-1,2,3-triazole-4-carboxyl chloride 
• 1093255-50-5 N-({4-chloro-3-[(3-chloro-5-cyanophenyl)oxy]-2-fluorophenyl}methyl)-5-methyl-2-phenyl-2H-1,2,3-triazole-4-carboxamide trifluoroacetate 
• 1133430-85-9 5-methyl-2-phenyl-2H-[1,2,3]triazole-4-carboxylic acid (1-ethyl-3-oxo-2,3-dihydro-1H-indazol-5-yl)-amide 
• 1083418-57-8 5-methyl-2-phenyl-2H-[1,2,3]triazole-4-carboxylic acid [5-chloro-2-(1H-tetrazol-5-yl)-phenyl]-amide 
• 1074763-05-5 5-methyl-N-((2R)-8-[(1-methylpiperidin-4-yl)oxy]-1,2,3,4-tetrahydronaphthalen-2-yl)-2-phenyl-2H-1,2,3-triazole-4-carboxamide 

Relevant articles and documents

Cu-Mediated Expeditious Annulation of Alkyl 3-Aminoacrylates with Aryldiazonium Salts: Access to Alkyl N2-Aryl 1,2,3-Triazole-carboxylates for Druglike Molecular Synthesis

Alkyl N-aryl 1,2,3-triazole-carboxylates are important molecules or intermediates in medicinal chemistry, but the synthesis of N2-aryl counterparts remains elusive. Herein, we describe a Cu-mediated annulation reaction of alkyl 3-aminoacrylates with aryldiazonium salts, both of which are readily available substrates. Furthermore, alkyl 2-aminoacrylates are also viable substrates. Diverse alkyl N2-aryl 1,2,3-triazole-carboxylates and their analogues can be rapidly prepared under mild conditions. Especially, this protocol allows one to access several druglike variants of carbonic anhydrase inhibitors and celecoxib.

Methylation of 3-Methyl- and 3-Phenyl-4-arylhydrazonoisoxazol-5-ones with Diazomethane

3-Methyl(or phenyl)-4-arylhydrazonoisoxazol-5-ones on methylation with diazomethane afford 3-methyl(or phenyl)-4-(N-methylarylhydrazono)isoxazol-5-ones and 3-methyl(or phenyl)-5-methoxy-4-arylhydrazonoisoxazoles.The latter compounds readily rearrange to 4