13331-19-6

Basic information

• Product Name: 2-PROPYLBENZENE-1,3-DIOL
• Synonyms: 2-PROPYLBENZENE-1,3-DIOL;2-PROPYLRESORCINOL;2-PROPYLBENZENE-1,3-DIOL (2-PROPYLRESORCINOL);2-n-Propylresorcinol, 98%;1,3-Dihydroxy-2-propylbenzene;2-Propylresorcin;NSC 95252;2-Propyl-1,3-Dihydroxybenzene
• CAS NO: 13331-19-6
• Molecular Formula: C₉H₁₂O₂
• Molecular Weight: 152.19
• Product Categories: Phenyls & Phenyl-Het;Phenyls & Phenyl-Het
• Mol File: 13331-19-6.mol

Chemical Properties

• Melting Point: 101-103°C
• Boiling Point: 280°C
• Flash Point: 135°C
• Appearance: /
• Density: 1.122
• Vapor Pressure: 0.001mmHg at 25°C
• Refractive Index: 1.565
• PKA: 9.97±0.10(Predicted)
• Water Solubility: Solightly soluble in water.
• CAS DataBase Reference: 2-PROPYLBENZENE-1,3-DIOL(CAS DataBase Reference)
• NIST Chemistry Reference: 2-PROPYLBENZENE-1,3-DIOL(13331-19-6)
• EPA Substance Registry System: 2-PROPYLBENZENE-1,3-DIOL(13331-19-6)

Safety Data

• Statements: 36/37/38
• Safety Statements: 26-36/37/39
• Hazardous Substances Data: 13331-19-6(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
2-Propylbenzene-1,3-diol is used as a building block for the preparation of azolylbutoxychromenone derivatives, which serve as liver X receptor β-selective agonists. These agonists play a crucial role in modulating various biological processes and have potential therapeutic applications in treating specific health conditions related to the liver and metabolic functions.
Used in Chemical Synthesis:
2-Propylbenzene-1,3-diol, due to its structural features, can be employed as an intermediate in the synthesis of various organic compounds, including pharmaceuticals, agrochemicals, and specialty chemicals. Its ability to form derivatives with diverse functional groups makes it a valuable component in the development of new molecules with specific applications.

InChI:InChI=1/C9H12O2/c1-2-4-7-8(10)5-3-6-9(7)11/h3,5-6,10-11H,2,4H2,1H3

Upstream product

• 1746-89-0 2-allyl-1,3-dihydroxybenzene 
• 3361-72-6 1-(2,6-dihydroxyphenyl)-1-propanone 
• 16929-64-9 1,3-Dimethoxy-2-(prop-1'-yl)benzene 
• 32774-65-5 2-n-propylcyclohexane-1,3-dione 
• 151-10-0 1,3-Dimethoxybenzene 
• 3993-57-5 7-allyloxy-4-methyl-2H-chromen-2-one 
• 150-19-6 O-methylresorcine 
• 172931-99-6 1,3-diethoxy-2-propylbenzene 
• 93114-94-4 3-methoxy-2-propylphenol 
• 37592-19-1 3-allyloxyanisole 
• 1616-54-2 8-allyl-7-hydroxy-4-methylcoumarin 
• 90-33-5 7-hydroxy-4-methyl-chromen-2-one 
• 93017-95-9 <3-Methoxy-2-propyl-phenyl>-4-brom-benzolsulfonat 

Downstream Products

• 84701-46-2 2,4-dihydroxy-3-propyl-benzaldehyde 
• 95225-49-3 1,3-bis-(4-nitro-benzoyloxy)-2-propyl-benzene 
• 40786-69-4 1-(2,4-dihydroxy-3-propylphenyl)ethanone 
• 79558-49-9 2,4-dihydroxy-3-propylphenyl ethyl ketone 
• 61270-29-9 3-Benzyloxy-2-propylphenol 
• 65239-69-2 2,4-dihydroxy-3-propyl-1',1',1'-trifluoroacetophenone 
• 183013-70-9 (2,4-Dihydroxy-3-propyl-phenyl)-pyridin-3-yl-methanone 
• 183013-71-0 (2,4-Dihydroxy-3-propyl-phenyl)-pyridin-4-yl-methanone 
• 705257-21-2 3-allyloxy-2-propyl-phenol 
• 664376-79-8 1-(2,4-dihydroxy-3-propylphenyl)-3-methylbutan-1-one 
• 194608-88-3 7-dipropyl-6-hydroxy-3-trifluoromethyl-1,2-benzisoxazole 
• 705257-43-8 4-allyl-2-propyl-benzene-1,3-diol 
• 355387-54-1 2,4-di-n-propylbenzene-1,3-diol 
• 449779-73-1 1-(2,4-dihydroxy-3,5-dipropyl-phenyl)-propan-1-one 

Relevant articles and documents

Design and discovery of 2-oxochromene derivatives as liver X receptor β-selective agonists

In an attempt to molecularly design liver X receptor (LXR) β-selective agonists, we discovered that the combination of the 2-oxochromene moiety (head) and the imidazoline-2,4-dione moiety (tail) plays an important role in the expression potency and select

CHROMEN-2-ONE DERIVATIVES

A compound of formula (I), wherein R1, R2, R3, R4, R5, and ring A are as defined in the specification, processes for their production, their uses, in particular in transplantation, and pharmaceutical

BENZYLIDENE RHODANINES

This invention provides novel benzylidene rhodanines which are useful as agents in treating or preventing conditions associated with . beta.-amyloid peptide. This invention further provides methods of treating or preventing Alzheimer's Disease which comprises administering to a mammal in need thereof an effective amount of one or more of the benzylidene rhodanines of the present invention.

Leukotriene antagonists for use in the treatment or prevention of alzheimer's disease

This invention provides methods for the treatment or prevention of Alzheimer's disease which comprises administering to a mammal in need thereof an effective amount of a compound having activity as a leukotriene antagonist.

Synthetic and structure/activity studies on acid-substituted 2- arylphenols: Discovery of 2-[2-propyl-3-[3-[2-ethyl-4-(4-fluorophenyl)-5- hydroxyphenoxy]-propoxy]phenoxy]benzoic acid, a high-affinity leukotriene B4 receptor antagonist

Structural derivatives of LY255283 have been studied as receptor antagonists of leukotriene B4. Substitution of the 2-hydroxyacetophenone subunit of 1 (LY255283) with a 2-arylphenol group provided entry into several new series that feature various mono- and diacidic core functionality. These new analogues, the subject of a broad structure-activity investigation, displayed significantly increased in vitro and in vive activity as receptor antagonists of LTB4. A series of diaryl ether carboxylic acids demonstrated especially interesting activity and led to the discovery of compound 43b, 2- [2-propyl-3-[3-[2-ethyl-4-(4-fluorophenyl)-5-hydroxyphenoxy]- propoxy]phenoxy]benzoic acid (LY293111), a 2-arylphenol-substituted diaryl ether carboxylic acid which displayed potent binding to human neutrophils (IC50 = 17 ± 4.6 nM) and guinea pig lung membranes (IC50 = 6.6 ± 0.71 nM), inhibition of LTB4-induced expression of the CD11b/CD18 receptor on human neutrophils (IC50 = 3.3 ± 0.81 nM), and inhibition of LTB4-induced contraction of guinea pig lung parenchyma (pK(B) = 8.7 ± 0.16). In vivo, 43b demonstrated potent activity in inhibiting LTB4-induced airway obstruction in the guinea pig when dosed by the oral (ED50 = 0.40 mg/kg) or intravenous (ED50 = 0.014 mg/kg) routes. A specific LTB4 receptor antagonist, 43b had little effect on inhibiting contractions of guinea pig lung parenchyma induced by leukotriene D4 (LTD4), histamine, carbachol, or U46619. Compound 43b has been chosen as a clinical candidate and is currently in phase I studies for a variety of inflammatory diseases.

SUBSTITUTED PHENYL PHENOL LEUKOTRIENE ANTAGONISTS

Antagonists having a substituted phenyl phenol or a substituted phenolic biphenyl structure, and various derivatives thereof, are specific leukotriene antagonists. Their structures, use and synthesis are disclosed. Also, pharmaceutical formulations are disclosed for use in applications treating diseases or conditions characterized by excessive release of leukotriene B 4, one of the metabolites of arachidonic acid.The primary LTB 4 antagonistic structures are represented as: STR1

USE OF PLA2 INHIBITORS AS TREATMENT FOR ALZHEIMER'S DISEASE

This invention provides methods for the treatment or prevention of Alzheimer's disease in a mammal which comprises administering to a mammal in need thereof an effective amount of an inhibitor of phospholipase A2. This invention also provides a series of compounds which are useful as inhibitors of phospholipases A2, especially cytosolic phospholipase A2.

LEUKOTRIENE B4 ANTAGONISTS

This invention relates to compounds of Formula I and the stereoisomers and pharmaceutically acceptable salts thereof STR1 wherein R is alkyl, alkenyl, alkynyl, or cycloalkylalkyl;R 1 is alkyl; R 2 is hydrogen, alkyl;R 6 is alkyl;

LEUKOTRIENE B4 ANTAGONISTS

This invention provides certain 1,2,4,5 substituted benzene derivatives containing "acid" substituents derived from cyclic or heterocyclic moieties. These unique compounds are leukotriene B 4 antagonists and formulations of these derivatives, and a method of using these derivatives for the treatment of conditions characterized by an excessive release of leukotrienes. "

Leukotriene B4 antagonists

This invention relates to compounds of Formula I and the stereoisomers and pharmaceutically acceptable salts thereof STR1 wherein R is alkyl, alkenyl, alkynyl, or cycloalkylalkyl; R1 is alkyl; R2 is hydrogen or alkyl; R6 i