79558-49-9

Usage

Preparation

Preparation by reaction of propionitrile with 2-propyl-resorcinol (Hoesch reaction) (80%).

Upstream product

• 13331-19-6 2-propyl-1,3-benzenediol 
• 107-12-0 propiononitrile 
• 74815-88-6 2,4-dihydroxy-3-allylpropiophenone 
• 5792-36-9 2',4'-dihydroxypropiophenone 
• 106627-40-1 4-(allyloxy)-2-hydroxypropiophenone 
• 16929-64-9 1,3-Dimethoxy-2-(prop-1'-yl)benzene 

Downstream Products

• 106627-30-9 diphenylmethyl 6-(4'-propanoyl-3'-hydroxy-2'-propylphenoxy)hexanoate 
• 194608-84-9 methyl 3-chloro-4-(3-(2-propyl-3-hydroxy-4-propionylphenoxy)propylthio)phenylacetate 
• 92518-45-1 6-(4-Propionyl-3-hydroxy-2-propylphenoxy)hexanoic acid 
• 118683-25-3 4-(3-Hydroxy-4-propionyl-2-propyl-phenoxymethyl)-3-methoxy-benzoic acid 
• 194608-85-0 {3-Chloro-4-[3-(3-hydroxy-4-{1-[(E)-hydroxyimino]-propyl}-2-propyl-phenoxy)-propylsulfanyl]-phenyl}-acetic acid methyl ester 
• 194608-87-2 {3-chloro-4-[3-(3-ethyl-7-propyl-benzo[d]isoxazol-6-yloxy)-propylsulfanyl]-phenyl}-acetic acid methyl ester 

Relevant academic research and scientific papers

Phenylacetic acid derivatives as hPPAR agonists

Beginning with the weakly active lead structure 1, a new series of hPPAR agonists was developed. In vivo glucose and triglyceride lowering activity was obtained by homologation and oxamination to 3, then conversion to substituted benzisoxazoles 4 and 5. F

Process for leukotriene antagonists

1,3-Dialkylbenzenes are acylated and deprotected in a mixture of acetic or propionic acid and hydrobromic acid. The dihydroxyphenones thus produced are intermediates in the synthesis of leukotriene antagonists.

Leukotriene receptor antagonists. 1. Synthesis and structure-activity relationships of alkoxyacetophenone derivatives

A series of derivatives of 2,4-dihydroxy-3-propylacetophenone were prepared and examined for their ability to block leukotriene D4 (LTD4) induced contraction of guinea pig ileum. Straight-chain carboxylic acids where the carboxyl gro