133311-51-0

Basic information

• Product Name: 2-Bromo-5-phenylthiazole
• Synonyms: 2-Bromo-5-phenylthiazole;Thiazole, 2-bromo-5-phenyl-
• CAS NO: 133311-51-0
• Molecular Formula: C₉H₆BrNS
• Molecular Weight: 240.12
• Mol File: 133311-51-0.mol

Chemical Properties

• Boiling Point: 330.536 °C at 760 mmHg
• Flash Point: 153.703 °C
• Appearance: /
• Density: 1.563 g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.635
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 2-Bromo-5-phenylthiazole(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Bromo-5-phenylthiazole(133311-51-0)
• EPA Substance Registry System: 2-Bromo-5-phenylthiazole(133311-51-0)

Safety Data

• Hazardous Substances Data: 133311-51-0(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
2-Bromo-5-phenylthiazole is used as a key intermediate in the synthesis of various pharmaceuticals. Its unique structure allows for the development of new drugs with improved therapeutic properties.
Used in Agrochemical Industry:
In the agrochemical industry, 2-Bromo-5-phenylthiazole is utilized as an intermediate for the production of agrochemicals, contributing to the development of effective pesticides and other agricultural chemicals.
Used in Organic Synthesis:
2-Bromo-5-phenylthiazole is used as a building block in organic synthesis for the creation of a wide variety of functionalized thiazole derivatives. Its reactivity and structural features make it a valuable component in the synthesis of complex organic molecules.
Used in Antimicrobial Applications:
2-Bromo-5-phenylthiazole has been studied for its potential antimicrobial properties, making it a candidate for use in the development of new antimicrobial agents to combat resistant bacteria and other pathogens.
Used in Anticancer Research:
2-Bromo-5-phenylthiazole has also been investigated for its anticancer properties, with potential applications in the development of novel anticancer drugs. Its biological activities are currently being explored to understand its mechanism of action and therapeutic potential in cancer treatment.

InChI:InChI=1/C9H6BrNS/c10-9-11-6-8(12-9)7-4-2-1-3-5-7/h1-6H

Upstream product

• 39136-63-5 5-phenyl-1,3-thiazol-2-amine 
• 7758-99-8 copper(II) sulfate 
• 3034-48-8 2-bromo-5-nitro-1,3-thiazole 
• 71-43-2 benzene 

Downstream Products

• 75427-04-2 N,N-dimethyl-5-phenylthiazol-2-amine 

Relevant articles and documents

PHD INHIBITOR COMPOUNDS, COMPOSITIONS, AND USE

The present invention provides, in part, novel small molecule inhibitors of PHD, having a structure according to Formula (A), and sub-formulas thereof: or a pharmaceutically acceptable salt thereof. The compounds provided herein can be useful for treatment of diseases including heart ( e.g. ischemic heart disease, congestive heart failure, and valvular heart disease), lung (e.g., acute lung injury, pulmonary hypertension, pulmonary fibrosis, and chronic obstructive pulmonary disease), liver (e.g. acute liver failure and liver fibrosis and cirrhosis), and kidney (e.g. acute kidney injury and chronic kidney disease) disease.

Novel Compounds

The present invention relates to novel compounds and methods for the manufacture of inhibitors of deubiquitylating enzymes (DUBs). In particular, the invention relates to the inhibition of ubiquitin C- terminal hydrolase 30 or Ubiquitin Specific Peptidase 30 (USP30). The invention further relates to the use of DUB inhibitors in the treatment of conditions involving mitochondrial dysfunction and cancer. Compounds of the invention include compounds having the formula (I): (I) or a pharmaceutically acceptable salt thereof, wherein R1a, R1b, R1c, R1d, R1e, R1f, R1g, R2, X, L and A are as defined herein.

Photochemical substitution of polyhalogenothiophene and halogenothiazole derivatives

The irradiation of 2,3-diodo-5-nitrothiophene in the presence of aromatic and heteroaromatic compounds gave the corresponding 2-aryl derivatives in high yields. The irradiation of 2,4-diiodo-5-nitrothiophene under the same conditions gave the corresponding 2-aryl derivatives in low yields. The observed difference in the reactivity can be explained on the basis of the hypothesis that the homolytic cleavage of the carbon-iodine bond occurred in a π,π* triplet state. Computational results showed that the lowest triplet state of the 2,3-diiodo isomer is π,π*, while that of the 2,4-isomer is π,π*. The irradiation of 2-bromo-5-nitrothiazole in the presence of benzene or indene gave the corresponding 2-bromo-5-arylthiazole. This behaviour can be explained by considering that the lowest excited triplet state cannot allow the cleavage of the carbon-bromine bond thus electron transfer occurs and leads to the substitution of the nitro group. The photochemical substitution reactions on 2,3-diiodo-5-nitrothiophene can be carried out in large scale using a new flow reactor using a PFTE pipe.

Antirhinoviral piperidinyl, pyrrolidinyl and piperazinyl alkylphenol ethers

Piperidinyl, pyrrolidinyl and piperazinyl alkylphenol ethers of formula X is N or CH; Alk is C1 4alkanediyl; R1 and R2 are hydrogen, C1 4alkyl or halo; R3 is hydrogen, halo, cyano, C1 4alky