133387-34-5

Basic information

• Product Name: 2,4-DiMorpholinonitrobenzene
• Synonyms: 2,4-DiMorpholinonitrobenzene;4,4'-(4-nitrobenzene-1,3-diyl)dimorpholine
• CAS NO: 133387-34-5
• Molecular Formula: C₁₄H₁₉N₃O₄
• Molecular Weight: 293.31836
• Mol File: 133387-34-5.mol

Chemical Properties

• Melting Point: 175-176 °C
• Boiling Point: 523.5±50.0 °C(Predicted)
• Appearance: /
• Density: 1.287±0.06 g/cm3(Predicted)
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 2.52±0.40(Predicted)
• CAS DataBase Reference: 2,4-DiMorpholinonitrobenzene(CAS DataBase Reference)
• NIST Chemistry Reference: 2,4-DiMorpholinonitrobenzene(133387-34-5)
• EPA Substance Registry System: 2,4-DiMorpholinonitrobenzene(133387-34-5)

Safety Data

• Hazardous Substances Data: 133387-34-5(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
2,4-DiMorpholinonitrobenzene is used as a chemical intermediate for the synthesis of various pharmaceuticals. Its unique structure allows it to be a key component in the development of new drugs, contributing to the advancement of medical treatments.
Used in Dye Industry:
In the dye industry, 2,4-DiMorpholinonitrobenzene is used as a building block in the production of dyes. Its chemical properties make it suitable for creating a range of colors and hues, enhancing the variety of dyes available for various applications.
Used in Chemical Reactions:
2,4-DiMorpholinonitrobenzene is used as a reagent in chemical reactions, facilitating the synthesis of other organic compounds. Its presence in these reactions can lead to the formation of new molecules with potential applications in various industries.
Used in Research and Development:
2,4-DiMorpholinonitrobenzene is also used in research and development settings, where its properties are studied and explored for potential new applications. This can lead to the discovery of innovative uses and further our understanding of its chemical behavior.

Upstream product

• 110-91-8 morpholine 
• 611-06-3 2,4-dichloronitrobenzene 
• 65976-63-8 4-(5-chloro-2-nitrophenyl)morpholine 
• 446-35-5 2,4-Difluoronitrobenzene 

Downstream Products

• 436088-92-5 2,4-bis(morpholin-4-yl)aniline 

Relevant articles and documents

Continuous Synthesis and Purification by Coupling a Multistep Flow Reaction with Centrifugal Partition Chromatography

Continuous-flow multistep synthesis is combined with quasi-continuous final-product purification to produce pure products from crude reaction mixtures. In the nucleophilic aromatic substitution of 2,4-difluoronitrobenzene with morpholine followed by a het

Continuous synthesis and purification by direct coupling of a flow reactor with simulated moving-bed chromatography

Continuous synthesis meets continuous purification to produce pure products from crude reaction mixtures. In the nucleophilic aromatic substitution of 2,4-difluoronitrobenzene with morpholine the desired monosubstituted product can be continuously separated from the byproducts in a purity of over 99 % by coupling a flow reactor to a simulated moving bed (SMB) chromatography module (see scheme). Copyright

Regular trends in nucleophilic substitutions in 2-alkylamino-4- chloronitrobenzenes

The effect of substituents in position 2 on the reactivity of 2-alkylamino-4-chloronitrobenzenes in nucleophilic substitution by N-nucleophiles of various character was studied. 2005 Pleiades Publishing, Inc.

Aromatic Nucleophilic Substitution of Halobenzenes with Amines under High Pressure

The nucleophilic substitution reactions of aromatic halides having electron-attracting groups on ortho or para position with various primary and secondary amines were accelerated by high pressure to give the corresponding N-substituted anilines in high yields.The bulkiness of amines affects its reactivity to lower the yields of the products.Although the secondary amines are usually less reactive than primary amines, cyclic secondary amines such as morpholine, piperidine, and pyrrolidine were found very reactive. 1,4-Diazabicyclooctane and quinuclidine gave N-quarternary ammonium halides in high yields in contrast to the low reactivity of acyclic tertiary amines.Dichloro- and trichloro-nitrobenzenes also react with diethylamine, pyrrolidine, and morpholine to give mono-, di-, and trisubstitution products depending upon the amount of amine and the position of nitro group in these chlorides.