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Candesartan-D4, a deuterated analog of Candesartan, is an angiotensin II type-1 receptor antagonist. It is primarily used as an internal standard for the quantification of candesartan by gas chromatography-mass spectrometry (GC-MS) or liquid chromatography-mass spectrometry (LC-MS). Candesartan-D4 exhibits high selectivity for the angiotensin II type 1 (AT1) receptor over the angiotensin II type 2 (AT2) receptor. It is characterized by its white to off-white solid appearance.

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  • 2-ethoxy-3-{[2'-(2H-1,2,3,4-tetrazol-5-yl)(2,3,5,6-2H )-[1,1'-biphenyl]-4-yl]methyl}-1,3-benzodiazole-4-carboxylic acid

    Cas No: 1346604-70-3

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  • 1346604-70-3 Structure
  • Basic information

    1. Product Name: CANDESARTAN-D4
    2. Synonyms: CANDESARTAN-D4;2-Ethoxy-1-[[2'-(1H-tetrazol-5-yl)[1-(phenyl-d4)-1'-phenyl]-4-yl]Methyl]-1H-benziMidazole-7-carboxylic Acid;Candesartan M1-d4;CV-11974-d4
    3. CAS NO:1346604-70-3
    4. Molecular Formula: C24H20N6O3
    5. Molecular Weight: 444.48
    6. EINECS: N/A
    7. Product Categories: Aromatics;Bases & Related Reagents;Intermediates & Fine Chemicals;Isotope Labelled Compounds;Nucleotides;Pharmaceuticals
    8. Mol File: 1346604-70-3.mol
  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: -20°C Freezer
    8. Solubility: DMSO (Slightly), Methanol (Slightly, Heated)
    9. CAS DataBase Reference: CANDESARTAN-D4(CAS DataBase Reference)
    10. NIST Chemistry Reference: CANDESARTAN-D4(1346604-70-3)
    11. EPA Substance Registry System: CANDESARTAN-D4(1346604-70-3)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 1346604-70-3(Hazardous Substances Data)

1346604-70-3 Usage

Uses

Used in Pharmaceutical Industry:
Candesartan-D4 is used as an internal standard for the quantification of candesartan in pharmaceutical research and development. It aids in the accurate measurement and analysis of candesartan levels in various formulations, ensuring the efficacy and safety of the drug.
Used in Treatment of Congestive Heart Failure:
Candesartan-D4, as an active metabolite of candesartan cilexitil, is employed in the treatment of congestive heart failure. It acts as an angiotensin II type-1 receptor antagonist, helping to improve the symptoms and outcomes for patients suffering from this condition.
Used as an Antihypertensive:
Candesartan-D4 is also used in the treatment of hypertension. By blocking the angiotensin II type-1 receptor, it helps to lower blood pressure and reduce the risk of cardiovascular events in patients with high blood pressure.

Check Digit Verification of cas no

The CAS Registry Mumber 1346604-70-3 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,3,4,6,6,0 and 4 respectively; the second part has 2 digits, 7 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 1346604-70:
(9*1)+(8*3)+(7*4)+(6*6)+(5*6)+(4*0)+(3*4)+(2*7)+(1*0)=153
153 % 10 = 3
So 1346604-70-3 is a valid CAS Registry Number.

1346604-70-3SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 18, 2017

Revision Date: Aug 18, 2017

1.Identification

1.1 GHS Product identifier

Product name Candesartan-d4

1.2 Other means of identification

Product number -
Other names 2-ethoxy-3-[[2,3,5,6-tetradeuterio-4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]benzimidazole-4-carboxylic acid

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:1346604-70-3 SDS

1346604-70-3Downstream Products

1346604-70-3Relevant articles and documents

Synthesis of deuterium-labeled olmesartan and candesartan

Zhang, Chi,Shen, Zucheng,Tian, Lei,Chen, Liqin

, p. 401 - 405 (2013/01/15)

This paper describes the synthesis of deuterium-labeled olmesartan and candesartan. The two desired compounds both used [2H4] 2-cyano-4'-methyl-biphenyl as deuterium-labeled reagent, which was synthesized beforehand in two steps. [2H4] olmesartan was synthesized in six steps further with 17% overall yield, and [2H4] candesartan was synthesized in seven steps further with 13% overall yield. Copyright 2012 John Wiley & Sons, Ltd. This paper describes the synthesis of deuterium-labeled olmesartan and candesartan. The two desired compounds both used [2H4] 2-cyano-4'-methyl-biphenyl as deuterium-labeled reagent, which was synthesized beforehand in two steps. [ 2H4] olmesartan was synthesized in a further six steps with a 17% overall yield, and [2H4] candesartan was synthesized in a further seven steps with a 13% overall yield. Copyright

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