134856-46-5

Basic information

• Product Name: Pyrido[1,2-a]benzimidazole, 1,2,3,4-tetrahydro-3-methyl- (9CI)
• Synonyms: Pyrido[1,2-a]benzimidazole, 1,2,3,4-tetrahydro-3-methyl- (9CI)
• CAS NO: 134856-46-5
• Molecular Formula: C12H14N2
• Molecular Weight: 186.25296
• Product Categories: BENZIMIDAZOLE
• Mol File: 134856-46-5.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Pyrido[1,2-a]benzimidazole, 1,2,3,4-tetrahydro-3-methyl- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Pyrido[1,2-a]benzimidazole, 1,2,3,4-tetrahydro-3-methyl- (9CI)(134856-46-5)
• EPA Substance Registry System: Pyrido[1,2-a]benzimidazole, 1,2,3,4-tetrahydro-3-methyl- (9CI)(134856-46-5)

Safety Data

• Hazardous Substances Data: 134856-46-5(Hazardous Substances Data)

Upstream product

• 201230-82-2 carbon monoxide 
• 134856-36-3 N-(3-Methylbut-3-enyl)-1,2-diaminobenzene 
• 336106-26-4 1-(3-methylbut-3-en-1-yl)-1H-benzo[d]imidazole 
• 491869-92-2 3-methyl-1-(methylthio)pyrido[1,2-a]benzimidazole 
• 51-17-2 benzoimidazole 
• 781-03-3 isopentenyl tosylate 
• 615-15-6 2-Methyl-1H-benzimidazole 
• 528877-71-6 2-[4-bis(methylthio)-2-hydroxy-2-methylbut-3-en-1-yl]benzimidazole 
• 13296-27-0 3-methylbut-3-en-1-amine 
• 88-73-3 2-Chloronitrobenzene 
• 134856-54-5 N-(3-methylbut-3-enyl)-2-nitrobenzenamine 

Relevant articles and documents

Enantioselective Aluminum-Free Alkene Hydroarylations through C?H Activation by a Chiral Nickel/JoSPOphos Manifold

Highly enantioselective nickel-catalyzed alkene endo-hydroarylations were accomplished with full selectivity by organometallic C?H activation. The asymmetric assembly of chiral six-membered scaffolds proved viable in the absence of pyrophoric organoaluminum reagents within an unprecedented nickel/JoSPOphos manifold.

Microwave-assisted C-H bond activation: A rapid entry into functionalized heterocycles

(Matrix presented) Microwave irradiation strongly accelerates the rhodium-catalyzed intramolecular coupling of a benzimidazole C-H bond to pendant alkenes. The cyclic products were formed in moderate to excellent yields with reaction times less than 20 min. Additionally, the use of microwave irradiation allowed the reactions to be performed without any solvent purification and with minimal precautions to exclude air.

Heteroaromatic annulation of 2-methyl/2-cyanomethylbenzimidazole dianions with α-oxoketene dithioacetals: A highly regioselective synthetic protocol for 1,2-and 2,3-substituted/annulated pyrido[1,2-a]benzimidazoles

A highly efficient and regioselective annulation protocol for a series of linearly 2,3- and angularly 1,2-substituted and annulated pyrido[1,2-α]benzimidazoles involving [3 + 3] cyclocondensation of the dianions generated from 2-methyl (2A) and 2-cyanomet

Synthesis of Benzimidazoles Containing a Fused Alicyclic Ring By Rhodium - Catalysed Hydroformylation of N-Alkenyl-1,2-diaminobenzenes

Rhodium-catalysed reactions of N-alkenyl-1,2-diaminobenzenes (3) with hydrogen and carbon monoxide give benzimidazoles containing a fused alicyclic ring ((8) and (9)) in excellent yields.In some cases intermediate bicyclic compounds can be isolated and the 1H and 13C n.m.r. spectra of one of these, the 3,4,5,6-tetrahydro-4-methyl-3H-1,6-benzodiazocine (6), shows evidence for unusual atropisomerism.

A metal catalysed route to benzimidazoles containing a fused alicyclic ring

Rhodium catalysed reactions of N-alkenyl-1,2-diaminobenzenes (1) with hydrogen and carbon monoxide give benzimidazoles containing a fused alicyclic ring (6,7) in excellent yields.