134896-35-8

Basic information

• Product Name: 2-PHENYL-3-NITROPYRIDINE
• Synonyms: 2-PHENYL-3-NITROPYRIDINE;3-NITRO-2-PHENYLPYRIDINE
• CAS NO: 134896-35-8
• Molecular Formula: C₁₁H₈N₂O₂
• Molecular Weight: 200.19
• Mol File: 134896-35-8.mol

Chemical Properties

• Boiling Point: 328.5 °C at 760 mmHg
• Flash Point: 152.4 °C
• Appearance: /
• Density: 1.252g/cm³
• Vapor Pressure: 0.000362mmHg at 25°C
• Refractive Index: 1.611
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 2-PHENYL-3-NITROPYRIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-PHENYL-3-NITROPYRIDINE(134896-35-8)
• EPA Substance Registry System: 2-PHENYL-3-NITROPYRIDINE(134896-35-8)

Safety Data

• Safety Statements: 24/25
• Hazardous Substances Data: 134896-35-8(Hazardous Substances Data)

Usage

Uses

Used in Organic Synthesis:
2-Phenyl-3-nitropyridine is used as a key intermediate in the synthesis of complex organic molecules. Its unique structure allows for a variety of chemical reactions, making it a valuable component in the creation of pharmaceuticals, agrochemicals, and other specialty chemicals.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 2-Phenyl-3-nitropyridine is used as a building block for the development of new drugs. Its reactivity and structural features enable the design of molecules with potential therapeutic applications, contributing to the advancement of medicinal chemistry.
Used in Agrochemical Industry:
2-Phenyl-3-nitropyridine is employed as a precursor in the synthesis of agrochemicals, such as pesticides and herbicides. Its properties allow for the creation of compounds that can effectively control pests and weeds, thereby supporting agricultural productivity.
Used in Specialty Chemicals:
2-Phenyl-3-nitropyridine is used as a starting material in the production of specialty chemicals, which are tailored for specific applications in various industries. Its versatility in chemical reactions facilitates the development of innovative products with unique properties and functions.

InChI:InChI=1/C11H8N2O2/c14-13(15)10-7-4-8-12-11(10)9-5-2-1-3-6-9/h1-8H

Upstream product

• 5470-18-8 2-Chloro-3-nitropyridine 
• 98-80-6 phenylboronic acid 
• 19755-53-4 2-bromo-3-nitropyridine 

Downstream Products

• 136871-75-5 (2S,3S)-2-phenyl-3-piperidinamine 
• 160551-72-4 cis-(+/-)-2-phenylpiperidin-3-ylamine 
• 168266-90-8 vofopitant 
• 160551-72-4 cis-2-phenyl-3-aminopiperidine 
• 161167-79-9 cis-3-amino-2-phenyl-piperidine 
• 1049706-68-4 3-nitro-2-phenylpyridine N-oxide 
• 1335110-51-4 3-nitro-2,4-diphenylpyridine 
• 1335110-63-8 3-nitro-2,4,5-triphenylpyridine 
• 1344663-79-1 3-nitro-2,6-diphenylpyridine-1-oxide 
• 1344663-80-4 3-nitro-2-phenyl-6-p-tolylpyridine-1-oxide 
• 1344663-81-5 6-(naphthalen-1-yl)-3-nitro-2-phenylpyridine-1-oxide 
• 1344663-82-6 3-nitro-2-phenyl-6-(thiophen-2-yl)pyridine-1-oxide 
• 1344663-83-7 6-(2-cyanophenyl)-3-nitro-2-phenylpyridine-1-oxide 
• 1344663-84-8 6-(2-(methoxycarbonyl)phenyl)-3-nitro-2-phenylpyridine-1-oxide 

Relevant articles and documents

3,3'-((Arylmethylene)bis(4-methoxy-3,1-phenylene)) dipyridine derivatives as convenient ligands for Suzuki–Miyaura chemo- and homoselective cross-coupling reactions

Four novel N,N-bidentate triarylmethane-based ligands bearing β-pyridyl residues have been prepared and the catalytic activity of their in-situ generated palladium complexes were studied in the Suzuki–Miyaura cross-coupling reactions. Air and moisture stable 3,3'-((arylmethylene)bis(4-methoxy-3,1-phenylene))dipyridines L1-3 showed excellent activity in the Suzuki coupling reactions of aryl halides with aryl boronic acids under thermal and sonochemical reaction conditions. The described methodology provided good to high yields in short reaction times at ambient conditions. Moreover, it offered a straightforward way for Suzuki–Miyaura chemo- and homoselective cross-coupling of aryl halides with phenyl boronic acid. The structures of synthesized compounds were fully characterized by FT-IR, 1H-NMR, 13C-NMR, and elemental analyses. The coordination of palladium acetate to nitrogen sites of L1 was also studied using FTIR spectroscopy, EDX analysis and SEM observations. Graphic abstract: The in-situ generated Pd-complexes of N,N-bidentate ligands L1-3 are described as robust and highly effective catalytic systems for the Suzuki cross-coupling of aryl halides with aryl boronic acids under thermal and sonochemical reaction conditions.[Figure not available: see fulltext.]

ORGANIC ELECTROLUMINESCENT MATERIALS AND DEVICES

A compound useful as a host material in phosphorescent light emitting devices is disclosed. The compound has the following formula: in which R represents an adjacent di-substitution having the following formula fused to ring A:

C6-Selective Direct Arylation of 2-Phenylpyridine via an Activated N-methylpyridinium Salt: A Combined Experimental and Theoretical Study

An elegant pre-activation strategy, based on the formation of N-methylpyridinium iodide salts for C6-selective direct arylation of 2-phenylpyridines using Pd/Cu cooperative catalysis, has been developed. By this methodology, a wide range of unsymmetrical 2, 6-diarylpyridines were synthesized with high reactivity and regioselectivity as well as good functional group tolerance. In particular, challenging substrates bearing electron donating groups (EDGs), such as OMe, NMe2, were also successfully employed in this reaction. Deuterium incorporation studies revealed that the C?H bond acidity is improved significantly in N-methylpyridinium salts compared with their N-Oxide and N-iminopyridinium ylide counterparts, thus solving the long-standing problem associated with previous strategies for the synthesis of diaryl pyridines. Finally, the control experiments and DFT calculations supported a Pd-catalyzed and Cu-mediated mechanism in which a carbenoid copper species that is formed in-situ from N-methylpyridinium salts, participates in a Pd-catalyzed arylation followed by an iodide-promoted N-demethylation process. (Figure presented.).

Metal-free deoxygenation and reductive disilylation of nitroarenes by organosilicon reducing reagents

A metal-free deoxygenation and reductive disilylation of nitroarenes was achieved using N,N’-bis(trime-thylsilyl)-4,4’-bipyridinylidene (1) under mild and neutral reaction conditions, and a broad functional group tolerance was possible in this reaction. Mono-deoxygenation, giving a synthetically valuable N,O-bis(trimethylsilyl)phe-nylhydroxylamine (7a) as a readily available and safe phenylnitrene source from nitrobenzene, and double-deoxy-genation, giving N,N-bis(trimethylsilyl)anilines 8, were easily controlled by varying the amounts of 1 and reaction temperature as well as adding dibenzothiophene (DBTP). Reaction of 2-arylnitrobenzenes with 1 resulted in the formation of the corresponding carbazoles 14 via in situ-gen-erated phenylnitrene species derived by thermolysis of N,O-bis(trimethylsilyl)phenylhydroxylamines 7, followed by their subsequent intramolecular C H insertion. In addition, the intramolecular N N coupling reaction proceeded in the reduction of 2,2’-dinitrobiphenyl derivatives by 1, giving the corresponding benzo[c]cinnolines.

Disubstituted derivative of carboline, and preparation method and application thereof

The invention especially relates to a disubstituted derivative of carboline, and a preparation method and application thereof, belonging to the technical field of organic electroluminescent materials. The disubstituted derivative of carboline can be used

Manipulation of electron deficiency of δ-carboline derivatives as bipolar hosts for blue phosphorescent organic light-emitting diodes with high efficiency at 1000 cd m-2

The effect of different linkages on thermal, electrochemical, photophysical, and optoelectronic properties was discussed in detail to illuminate the structure-property relationship of four δ-carboline derivatives, 5-(3′-(9H-carbazol-9-yl)-[1,1′-biphenyl]-

NOVEL ORGANIC ELECTROLUMINESCENT COMPOUNDS AND ORGANIC ELECTROLUMINESCENT DEVICE USING THE SAME

The present invention relates to a novel organic electroluminescent compound and an organic electroluminescent device adopting the same, and more specifically, to an organic electroluminescent compound represented by chemical formula 1 below. In the chemical formula 1, ring A and ring B are independently a monocyclic or polycyclic aromatic ring, a monocyclic or polycyclic heteroaromatic ring, a five- or six-membered heteroaromatic ring fused with an aromatic ring, or a monocyclic or polycyclic aromatic ring fused with a five- or six-membered heteroaromatic ring, where the ring A and ring B cannot both be a monocyclic aromatic ring. The organic electroluminescent compound according to the present invention shows good luminous efficiency, and superior material color purity and lifetime characteristics, thereby enabling manufacture of an OLED device with excellent driving time.COPYRIGHT KIPO 2016

TRKA KINASE INHIBITORS, COMPOSITIONS AND METHODS THEREOF

The present invention is directed to six membered heteroaryl benzamide compounds of formula (I), which are tropomyosin-related kinase (Trk) family protein kinase inhibitors, and hence are useful in the treatment of pain, inflammation, cancer, restenosis, atherosclerosis, psoriasis, thrombosis, a disease, disorder, injury, or malfunction relating to dysmyelination or demyelination or a disease or disorder associated with abnormal activities of nerve growth factor (NGF) receptor TrkA.

Complete Switch of Selectivity in the C-H Alkenylation and Hydroarylation Catalyzed by Iridium: The Role of Directing Groups

A complete switch in the CpIr(III)-catalyzed paths between C-H olefination and hydroarylation was found to be crucially dependent on the type of directing groups. This dichotomy in product distribution was correlated to the efficiency in attaining syn-coplanarity of olefin-inserted 7-membered iridacycles. Theoretical studies support our hypothesis that the degree of flexibility of this key intermediate modulates the β-H elimination, which ultimately affords the observed chemoselectivity.

Synthesis and characterization of hydrophilic theophylline base compounds and their use as ligands in the microwave assisted Suzuki-Miyaura couplings of halopyridines in water Dedicated to the memory of Prof. Dr. Armando Cabrera Ortiz pioneer of Catalysis in Mexico. Great Researcher but above all a Great Human Being

Xanthine derivatives, caffeine (L1), theobromine (L2), theophylline (L3), 7-(β-hydroxyethyltheophylline) (L4), (7-(2,3-dihydroxypropyl)theophylline) (L5), and theophylline 7-acetic acid (L6) and the acetylated derivatives of the later three (L7-L9) were employed as ligands for the in situ palladium catalyzed Suzuki-Miyaura cross couplings of a series of halogenated pyridines. Optimized conditions were found where the diacetylated ligand (L8) was determined to be the best for this process, producing good to excellent yields in the couplings of halogenated anilines with phenylboronic acid under mild reaction conditions in water using microwave irradiation.