1350749-64-2

Basic information

• Product Name: Carbamic acid, N-[(1R,2S)-2-(3,4-difluorophenyl)cyclopropyl]-, 1,1-dimethylethyl ester
• CAS NO: 1350749-64-2
• Molecular Formula: C14H17F2NO2
• Molecular Weight: 269.291
• Mol File: 1350749-64-2.mol

Chemical Properties

• CAS DataBase Reference: Carbamic acid, N-[(1R,2S)-2-(3,4-difluorophenyl)cyclopropyl]-, 1,1-dimethylethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Carbamic acid, N-[(1R,2S)-2-(3,4-difluorophenyl)cyclopropyl]-, 1,1-dimethylethyl ester(1350749-64-2)
• EPA Substance Registry System: Carbamic acid, N-[(1R,2S)-2-(3,4-difluorophenyl)cyclopropyl]-, 1,1-dimethylethyl ester(1350749-64-2)

Safety Data

• Hazardous Substances Data: 1350749-64-2(Hazardous Substances Data)

Upstream product

• 367-11-3 ortho-difluorobenzene 
• 376608-71-8 trans-(1R,2S)-2-(3,4-difluorophenyl)cyclopropylamine (2R)-2-hydroxy-2-phenylacetic acid salt 
• 24424-99-5 di-tert-butyl dicarbonate 
• 1006614-49-8 (1R,2S)-2-(3,4-difluorophenyl)cyclopropanamine 
• 1345413-25-3 (1S)-1-(3,4-difluorophenyl)-3-nitropropan-1-ol 
• 1345413-26-4 trans-(1R,2S)-2-(3,4-difluorophenyl)-1-nitrocyclopropane 
• 1215969-79-1 3-chloro-1-(3',4'-difluorophenyl)-propan-1-one 
• 378236-67-0 (1R,2R)-2-(3,4-difluorophenyl)cyclopropanecarbonyl azide 
• 75-65-0 tert-butyl alcohol 
• 220352-36-3 trans-(1R,2R)-2-(3,4-difluorophenyl)cyclopropanecarboxylic acid 
• 1459720-02-5 (1R,2S)-2-(3,4-difluorophenyl)cyclopropanoic acid methyl ester 
• 1459720-05-8 (1R,2R)-2-(3,4-difluorophenyl)cyclopropanecarbohydrazide 

Downstream Products

• 1383715-58-9 tert-butyl (6-chloro-5-nitro-2-(propylthio)pyrimidin-4-yl)((1R,2S)-2-(3,4-difluorophenyl)cyclopropyl)carbamate 
• 274693-26-4 [3aR-[3aα,4α,6α,(1R,2S),6aα]]-2-[6-[[[7-(2-(3,4-difluorophenyl)cyclopropyl)]amino-5-(propylthio)-3H-1,2,3-triazolo[4,5-d]pyrimidin-3-yl]tetrahydro-2,2-dimethyl-4H-cyclopenteno-1,3-dioxolan-4-yl]oxy]ethanol 
• 274693-27-5 ticagrelor 
• 1383715-59-0 2-[[(3aR,4S,6R,6aS)-6-[[4-[N-[(1R,2S)-2-(3,4-difluorophenyl)cyclopropan-1-yl]-N-tert-butoxycarbonyl]amino]-2-(propylthio)-5-nitropyrimidin-6-yl]-2,2-dimethyl-tetrahydro-3aH-cyclopenta[d][1,3]dioxol-4-yl]oxy] ethanol 
• 1402222-66-5 trans-(1R,2S)-2-(3,4-difluorophenyl)cyclopropylamine hydrochloride 
• 1006614-49-8 (1R,2S)-2-(3,4-difluorophenyl)cyclopropanamine 
• 1427524-43-3 tert-butyl ((1R,2S)-2-(3,4-difluorophenyl)cyclopropyl)(3-((1R,2S,3S,4S)-2,3-dihydroxy-4-(2-hydroxyethoxy)cyclopentyl)-5-(propylthio)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-7-yl)carbamate 
• 1451195-45-1 tert-butyl (5-nitro-6-(((1R,2S,3S,4S)-2,3-dihydroxy-4-(2-hydroxyethoxy)cyclopentyl)amino)-2-(propylthio)pyrimidin-4-yl)((1R,2S)-2-(3,4-difluorophenyl)cyclopropyl)carbamate 
• 1451196-00-1 tert-butyl ((1R,2S)-2-(3,4-difluorophenyl)cyclopropyl)(6-(((1R,2S,3S,4S)-2,3-dihydroxy-4-(2-hydroxyethoxy)cyclopentyl)amino)-5-nitro-2-(propylthio)pyrimidin-4-yl)carbamate 
• 1427523-82-7 methyl 2-(((3aR,4S,6R,6aS)-6-(7-((tert-butoxycarbonyl)((1R,2S)-2-(3,4-difluorophenyl)cyclopropyl)amino)-5-(propylthio)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl)-2,2-dimethyltetrahydro-3aH-cyclopenta[d][1,3]dioxol-4-yl)oxy)acetate 
• 1427523-80-5 tert-butyl (5-amino-6-(((3aS,4R,6S,6aR)-6-hydroxy-2,2-dimethyltetrahydro-3aH-cyclopenta[d][1,3]dioxol-4-yl)amino)-2-(propylthio) pyrimidin-4-yl)((1R,2S)-2-(3,4-difluorophenyl)cyclopropyl)carbamate 
• 1427523-79-2 tert-butyl ((1R,2S)-2-(3,4-difluorophenyl)cyclopropyl)(6-(((3aS,4R,6S,6aR)-6-hydroxy-2,2-dimethyltetrahydro-3aH-cyclopenta[d][1,3]dioxol-4-yl)amino)-5-nitro-2-(propylthio)pyrimidin-4-yl)carbamate 
• 1383715-64-7 2-({(3aR,45,6R,6aS)-6-[7-{[[N-(1R,2S)-2-(3,4-difluorophenyl)-cyclopropan-1-yl]-N-tert-butoxycarbonyl]amino}-5-(propylthio)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl]-2,2-dimethyl-tetrahydro-3aH-cyclopenta[d][1,3]dioxol-4-yl}oxy)-O-tertbutoxycarbonylethanol 
• 1383715-63-6 C₃₀H₃₄F₂N₆O₄S 

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The present invention relates to the filed of organic synthesis and describes the synthesis of specific triazolopyrimidine compounds and intermediates thereof as well as related derivatives, suitable for the preparation of ticagrelor (TGC)

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