135124-71-9

Basic information

• Product Name: (5-CYANOPYRIDIN-3-YL)-METHANOL
• Synonyms: (5-CYANOPYRIDIN-3-YL)-METHANOL;3-Pyridinecarbonitrile,5-(hydroxymethyl)-(9CI);5-(hydroxyMethyl)nicotinonitrile;5-(hydroxyMethyl)-3-Pyridinecarbonitrile;5-(hydroxymethyl)pyridine-3-carbonitrile
• CAS NO: 135124-71-9
• Molecular Formula: C₇H₆N₂O
• Molecular Weight: 134.14
• EINECS: 604-604-1
• Product Categories: PYRIDINE
• Mol File: 135124-71-9.mol

Chemical Properties

• Boiling Point: 315 °C at 760 mmHg
• Flash Point: 144.3 °C
• Appearance: /
• Density: 1.25 g/cm³
• Vapor Pressure: 0.00019mmHg at 25°C
• Refractive Index: 1.575
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: 13.26±0.10(Predicted)
• CAS DataBase Reference: (5-CYANOPYRIDIN-3-YL)-METHANOL(CAS DataBase Reference)
• NIST Chemistry Reference: (5-CYANOPYRIDIN-3-YL)-METHANOL(135124-71-9)
• EPA Substance Registry System: (5-CYANOPYRIDIN-3-YL)-METHANOL(135124-71-9)

Safety Data

• RIDADR: UN1759
• Hazardous Substances Data: 135124-71-9(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
(5-Cyanopyridin-3-yl)-methanol is used as a building block for the synthesis of various pharmaceuticals due to its ability to introduce the cyanopyridine functionality into different molecular structures. This makes it a valuable tool in the development of new drugs with potential therapeutic applications.
Used in Agrochemical Industry:
(5-Cyanopyridin-3-yl)-methanol is used as an intermediate in the production of agrochemicals, contributing to the development of effective and targeted pest control solutions.
Used in Organic Synthesis:
(5-Cyanopyridin-3-yl)-methanol is used as a reagent in organic synthesis to introduce the cyanopyridine functionality into various molecules, expanding the scope of chemical reactions and the creation of novel compounds.
Used in the Production of Biologically Active Compounds:
(5-Cyanopyridin-3-yl)-methanol is used as a key intermediate in the synthesis of biologically active compounds, which can have potential applications in medicine, agriculture, and other fields.

InChI:InChI=1/C7H6N2O/c8-2-6-1-7(5-10)4-9-3-6/h1,3-4,10H,5H2

Upstream product

• 37669-64-0 (5-bromopyridin-3-yl)methanol 
• 20826-04-4 5-bromo-3-pyridinecarboxylic acid 
• 70416-53-4 5-formylpyridine-3-carbonitrile 
• 100949-02-8 5-vinylnicotinonitrile 
• 35590-37-5 5-bromopyridine-3-carbonitrile 
• 557-21-1 zinc(II) cyanide 
• 29681-44-5 5-bromo-3-pyridine carboxylic acid methyl ester 
• 106726-82-3 3-Cyano-5-methoxycarbonylpyridine 
• 544-92-3 copper(I) cyanide 

Downstream Products

• 94413-65-7 5-aminomethyl-3-pyridinecarbonitrile 
• 1211530-54-9 5-(bromomethyl)pyridine-3-carbonitrile 
• 70416-53-4 5-formylpyridine-3-carbonitrile 
• 562074-59-3 5-(chloromethyl)nicotinonitrile hydrochloride 

Relevant articles and documents

Novel biphenyl derivative as well as preparation method and medical application thereof

The invention relates to the field of medicinal chemistry, and discloses biphenyl derivatives with PD-1/PD-L1 inhibitory activity as well as a preparation method and application of the biphenyl derivatives. The invention further discloses a composition containing the biphenyl derivative with the PD-1/PD-L1 inhibitory activity or the pharmaceutically acceptable salt of the biphenyl derivative and a pharmaceutically acceptable carrier of the biphenyl derivative, and application of the biphenyl derivative in preparation of a PD-1/PD-L1 inhibitor. The compound can be used for treating tumors.

SUBSTITUTED 1,1'-BIPHENYL COMPOUNDS AND METHODS USING SAME

The present invention includes substituted 1,1'-biphenyl compounds, analogues thereof, and compositions comprising the same. In one aspect, the compounds contemplated in the invention can be used to treat, ameliorate, or prevent hepatitis B virus (HBV) and/or hepatitis D virus (HDV) infections in a patient. In another aspect, the compounds contemplated in the invention can be used to treat, ameliorate, and/or prevent cancer in a patient.

Heterocycle-substituted styryl-4-phenylpyridine derivative as well as preparation method and medical application thereof

The invention relates to a heterocycle-substituted styryl-4-phenylpyridine derivative, a preparation method thereof and an application of the heterocycle-substituted styryl-4-phenylpyridine derivativeas a PD-1/PD-L1 inhibitor. Specifically, the invention discloses a compound shown as a formula (I) or pharmaceutically acceptable salt, stereoisomer, solvate or prodrug thereof, and a preparation method and application thereof, and the definition of each group in the formula is shown in the specification and claims in detail.

PYRIMIDINE DERIVATIVES AS INHIBITORS OF PD1/PD-L1 ACTIVATION

The compounds of Formula Ib, Formula Ia, and Formula I are described herein along with their polymorphs, stereoisomers, tautomers, prodrugs, solvates, and pharmaceutically acceptable salts thereof. The process of preparation of the compounds of Formula Ib, Formula Ia, and Formula I is also described. The compounds described herein, their polymorphs, stereoisomers, tautomers, prodrugs, solvates, and pharmaceutically acceptable salts thereof are 2-(benzyloxy)pyrimidine derivatives that are inhibitors of PD-1/PD-L1 activation.

BICYCLIC COMPOUNDS AS INHIBITORS OF PD1/PD-L1 INTERACTION/ACTIVATION

The compounds of Formula I is described herein along with their polymorphs, stereoisomers, tautomers, prodrugs, solvates, and pharmaceutically acceptable salts thereof. The compounds described herein, their polymorphs, stereoisomers, tautomers, prodrugs, solvates, and pharmaceutically acceptable salts thereof are bicyclic compounds that are inhibitors of PD-1/PD-L1 interaction/activation.

SUBSTITUTED 1,1'-BIPHENYL COMPOUNDS, ANALOGUES THEREOF, AND METHODS USING SAME

The present invention includes substituted 3,3'-bis(phenoxymethyl)-1,1'-biphenyl compounds, analogues thereof, and compositions comprising the same, that can be used to treat or prevent hepatitis B virus (HBV) and/or hepatitis D virus (HDV) infections in a patient.

UREA COMPOUND AND PREPARATION METHOD AND APPLICATION THEREOF

The present invention relates to a urea compound and a preparation method and an application thereof. The structure of the present compound is represented by formula (I), the definition of each variable in the formula being as described in the description. The compound can block interaction between the PD-1/PD-L1 signalling pathways. The compound of the present invention can be used for treating or preventing diseases related to the signalling pathways, such as cancer, autoimmune disease, chronic infectious disease, and other diseases.

IMMUNE CHECKPOINT INHIBITORS, COMPOSITIONS AND METHODS THEREOF

The present invention provides synthesis, pharmaceutically acceptable formulations and uses of compounds in accordance with Formula (I), or a stereoisomer, a tautomer or a pharmaceutically acceptable salt thereof. For Formula (I) compounds R1, R2, X1, Y1 and n are as defined in the specification. The inventive Formula (I) compounds are inhibitors of the PD-1/PD-L1 protein/protein binding or functional interaction and find utility in any number of therapeutic applications, including but not limited to treatment of proliferative disorders such as cancer and infectious diseases.

DERIVATIVES OF 2-PYRIDIN-2-YL-PYRAZOL-3(2H)-ONE, PREPARATION AND THERAPEUTIC USE THEREOF AS HIF ACTIVATORS

The present invention relates to novel substituted dihydropyrazolone derivatives, to their preparation and to their therapeutic use as activators of the transcription factor HIF.

Substituted 4-aryl-4h-pyrrolo[2,3-h]chromenes and analogs as activators of caspases and inducers of apoptosis and the use thereof

The present invention is directed to substituted 4H-chromenes and analogs thereof, represented by the Formula (I): wherein R1, R3-R5, A, D, Y and Z are defined herein. The present invention also relates to the discovery that compounds having Formula (I) are activators of caspases and inducers of apoptosis. Therefore, the activators of caspases and inducers of apoptosis of this invention can be used to induce cell death in a variety of clinical conditions in which uncontrolled growth and spread of abnormal cells occurs.