135132-34-2

Usage

Uses

Used in Pharmaceutical Industry:
5-CYANO-2,2-DIFLUORO-1,3-BENZODIOXOLE is used as an intermediate in the synthesis of pharmaceuticals for its ability to contribute to the development of new drug molecules. Its unique structure allows for the creation of a variety of compounds with potential therapeutic applications.
Used in Agrochemical Industry:
In the agrochemical sector, 5-CYANO-2,2-DIFLUORO-1,3-BENZODIOXOLE is utilized as an intermediate in the production of agrochemicals, specifically pesticides and herbicides. Its incorporation into these products can enhance their effectiveness in controlling pests and weeds in agricultural settings.
Used in Organic Chemistry Research:
5-CYANO-2,2-DIFLUORO-1,3-BENZODIOXOLE serves as a valuable building block in organic chemistry, enabling the synthesis of complex molecules with potential applications in various fields. Researchers use 5-CYANO-2,2-DIFLUORO-1,3-BENZODIOXOLE to explore new reaction pathways and develop innovative chemical processes.
Used in Biological Activity Studies:
5-CYANO-2,2-DIFLUORO-1,3-BENZODIOXOLE is being investigated for its biological activities, which may include potential uses in medicine or as a tool to understand biological processes. 5-CYANO-2,2-DIFLUORO-1,3-BENZODIOXOLE's structure and properties make it a candidate for studies aimed at identifying new bioactive molecules.
Safety Precautions:

InChI:InChI=1/C4H7F3O2/c5-4(6,7)3(9)1-2-8/h3,8-9H,1-2H2

Upstream product

• 1269251-98-0 2-thioxobenzo[d][1,3]dioxole-5-carbonitrile 
• 17345-61-8 3,4-dihydroxybenzonitrile 
• 33070-32-5 5-bromo-2,2-difluoro-2H-1,3-benzodioxole 
• 557-21-1 zinc(II) cyanide 

Downstream Products

• 656-46-2 2,2-difluoro-1,3-benzodioxole-5-carboxylic acid 

Relevant academic research and scientific papers

Synthesis of difluoroaryldioxoles using BrF3

A novel synthesis of different aromatic and heteroaromatic difluorodioxole derivatives has been developed. The starting materials were catechols, which, after treatment with thiophosgene, formed at 0 °C the respective thiodioxoles. The latter were reacted for a short time with commercially available bromine trifluoride, producing potentially biologically important difluoroaryldioxoles in moderate to high yields.

COMPOUNDS AND USES THEREOF

The present invention features compounds useful in the treatment of neurological disorders. The compounds of the invention, alone or in combination with other pharmaceutically active agents, can be used for treating or preventing neurological disorders.

A 2, 2 - difluoro pepper acid methyl ester preparation method

The invention discloses a preparation method of methyl 2,2-difluorobenzo[d][1,3]dioxole-5-carboxylate. The method comprises the steps of performing cyanation reaction to 5-bromo-2,2-difluoro-1,3-benzodioxole and cuprous cyanide, then performing hydrolysis to form acid, and then performing esterification to obtain 2,2-difluorobenzo[d][1,3]dioxole-5-carboxylate. In the preparation method disclosed by the invention, by using 5-bromo-2,2-difluoro-1,3-benzodioxole as a start raw material, performing cyanation by using low-toxicity cuprous cyanide, then performing hydrolysis to form acid and performing methanol reaction esterification to obtain the product, the process flow of the method is simple and the reaction process is easy to control. In the reaction process, the purification of the intermediate product produced in each step does not need a complex purification process, the purification process is simple, the purification yield is high, the entire process flow is simple and high-efficiency, the product yield is high, the cost of the entire flow is low and the preparation method is very suitable for large-scale industrial production.