656-46-2

Usage

Uses

Used in Pharmaceutical Industry:
2,2-Difluorobenzodioxole-5-carboxylic acid is used as a key intermediate in the synthesis of various pharmaceuticals for its potential therapeutic properties. Its unique structure allows for the development of new drugs with improved efficacy and selectivity, contributing to advancements in drug discovery and development.
Used in Agrochemical Industry:
In the agrochemical industry, 2,2-Difluorobenzodioxole-5-carboxylic acid is used as a building block for the synthesis of various agrochemicals. Its unique chemical properties make it suitable for the development of new pesticides, herbicides, and other agricultural chemicals, enhancing crop protection and yield.
Used in Organic Synthesis:
2,2-Difluorobenzodioxole-5-carboxylic acid is used as a versatile intermediate in organic synthesis for the preparation of a wide range of organic compounds. Its unique structure allows for the formation of various functional groups and chemical entities, making it a valuable compound for the synthesis of specialty chemicals, fine chemicals, and other organic products.

InChI:InChI=1/C8H4F2O4/c9-8(10)13-5-2-1-4(7(11)12)3-6(5)14-8/h1-3H,(H,11,12)/p-1

Upstream product

• 135132-34-2 2,2-difluorobenzo-1,3-dioxole-5-carbonitrile 
• 33070-32-5 5-bromo-2,2-difluoro-2H-1,3-benzodioxole 
• 124-38-9 carbon dioxide 
• 773873-95-3 2,2-difluorobenzo[1,3]dioxole-5-carboxylic acid methyl ester 
• 1583-59-1 2,2-difluoro-1,3-benzodioxole 

Downstream Products

• 127163-51-3 2,2-difluorobenzo[d][1,3]dioxole-5-carbonyl chloride 
• 476473-97-9 5-chloromethyl-2,2-difluoro-benzo[1,3]dioxole 
• 68119-31-3 2-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)acetonitrile 
• 72768-97-9 (2,2-difluoro-1,3-benzodioxol-5-yl)methanol 
• 773873-95-3 2,2-difluorobenzo[1,3]dioxole-5-carboxylic acid methyl ester 

Relevant academic research and scientific papers

A 2, 2 - difluoro pepper acid methyl ester preparation method

The invention discloses a preparation method of methyl 2,2-difluorobenzo[d][1,3]dioxole-5-carboxylate. The method comprises the steps of performing cyanation reaction to 5-bromo-2,2-difluoro-1,3-benzodioxole and cuprous cyanide, then performing hydrolysis to form acid, and then performing esterification to obtain 2,2-difluorobenzo[d][1,3]dioxole-5-carboxylate. In the preparation method disclosed by the invention, by using 5-bromo-2,2-difluoro-1,3-benzodioxole as a start raw material, performing cyanation by using low-toxicity cuprous cyanide, then performing hydrolysis to form acid and performing methanol reaction esterification to obtain the product, the process flow of the method is simple and the reaction process is easy to control. In the reaction process, the purification of the intermediate product produced in each step does not need a complex purification process, the purification process is simple, the purification yield is high, the entire process flow is simple and high-efficiency, the product yield is high, the cost of the entire flow is low and the preparation method is very suitable for large-scale industrial production.

PROCESS FOR THE PREPARATION OF DERIVATIVES OF BENZODIOXOLE

The present invention relates to the process for preparing compounds of Formula I, Formula III and Formula V.

HETEROCYCLIC COMPOUNDS FOR THE INHIBITION OF PASK

Disclosed herein are new heterocyclic compounds and compositions and their application as pharmaceuticals for the treatment of disease. Methods of inhibiting PAS Kinase (PASK) activity in a human or animal subject are also provided for the treatment of diseases such as diabetes mellitus.

Process for the preparation of derivatives of difluorobenzo-(1,3)-dioxole-5-carboxylic acid

Preparation of difluorobenzo-[1,3]-dioxol-5-carbonic acid and its derivatives comprises reacting difluorobenzo-[1,3]-dioxol compound (II) in the presence of boron trifluoride and hydrogen fluoride to give difluoro-benzo[1,3]dioxol-5-carbonic acid-2-hydroxy-phenylester compound (III), optionally at least partially distilling boron trifluoride and/or hydrogen fluoride, and hydrolysing in aqueous acid or in alkaline medium to give (I). Preparation of difluorobenzo-[1,3]-dioxol-5-carbonic acid and its derivatives comprises reacting difluorobenzo-[1,3]-dioxol compound of formula (II) in the presence of boron trifluoride and hydrogen fluoride to give difluoro-benzo[1,3]dioxol-5-carbonic acid-2-hydroxy-phenylester compound of formula (III), optionally at least partially distilling boron trifluoride and/or hydrogen fluoride, and hydrolysing in aqueous acid or in alkaline medium to give (I). R 1>1-12C alkyl, 1-12C fluoroalkyl, 1-12C alkoxy, 1-12C fluoroalkoxy, Br, Cl or F; and n : 0-3. Independent claims are also included for: (1) New difluoro-benzo[1,3]dioxol-5-carbonic acid-2-hydroxy-phenylester compounds (III) and its phenolate salts; and (2) preparation of difluorobenzo-[1,3]-dioxol-chloride compounds of formula (IV) comprising preparing (I) and reacting (I) with chlorinating agents. [Image] [Image].

Process for preparing difluorobenzo-1,3-dioxole-5-carboxylic acid derivatives

The invention relates to a process for preparing difluorobenzo-1,3-dioxole-5-carboxylic acid and derivatives thereof, and to the use thereof for preparing medicaments and crop protection agents.