1355249-47-6

Basic information

• Product Name: C₂₂H₂₈N₄O₅S
• Synonyms: C₂₂H₂₈N₄O₅S
• CAS NO: 1355249-47-6
• Molecular Weight: 460.554
• Mol File: 1355249-47-6.mol

Chemical Properties

• CAS DataBase Reference: C₂₂H₂₈N₄O₅S(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₂H₂₈N₄O₅S(1355249-47-6)
• EPA Substance Registry System: C₂₂H₂₈N₄O₅S(1355249-47-6)

Safety Data

• Hazardous Substances Data: 1355249-47-6(Hazardous Substances Data)

Upstream product

• 1355249-46-5 C₂₄H₂₈N₄O₆S 
• 1355249-45-4 C₁₀H₁₃BrN₂O₃S 
• 1355249-44-3 C₁₀H₁₅BrN₂O₃S 
• 1355249-30-7 C₂₀H₂₇BN₂O₅ 
• 1355249-29-4 ethyl 4-iodo-1-(4-methoxybenzyl)-1H-pyrazole-3-carboxylate 
• 944805-17-8 tert-butyl (4-bromo-5-formylthiazol-2-yl)carbamate 

Downstream Products

• 1355249-48-7 C₁₇H₁₈N₄O₂S 
• 1355249-49-8 C₂₂H₂₂N₆O₂S 

Relevant articles and documents

TRICYCLIC COMPOUNDS AS ALLOSTERIC MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS

The present invention describes and claims compounds of the Structural Formula (I), Structural Formula (II), or Structural Formula (III). In Formula (I), R1, R2, R3 and R3' are -H or methyl, or R3 and R3' taken together form a double bond, or R3' is -H and R2 and R3 taken together form a spiro-cyclopropyl substituent, R4 is -H or -F, and R5 is -H, methyl, -Cl or -Br. In Formula (II), R1 is -H, ethyl-, isopropyl-, cyclopropyl-, methyl- or methoxy-, R4 is -H or -F, and "Y" is: (a) -CH2-; (b) -CR6H-O-CR7R8-, wherein R6, R7, and R8 are independently -H or methyl; (c) -CR6H-N(R9)-CR7R8-, wherein R6, R7, and R8 are independently -H or methyl; (d) -CH2-C(R9)(R10)-C(R7)(R8)-, wherein R7, R8, R9 and R10 are independently -H or -methyl, or both R7 and R8 are -F, R9 and R10 are independently -H or -methyl, or both R9 and R10 are -F, or R9 and R10 taken together are (O=), which together with the carbon to which they are attached forms a carbonyl group.

TRICYCLIC COMPOUNDS AS ALLOSTERIC MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS

The present invention describes and claims compounds of the Structural Formula I, Structural Formula II, or Structural Formula III: wherein R1, R2, R3 and R3' are -H or methyl, or R3 and R3 taken together form a double bond, or R3' is -H and R2 and R3 taken together form a spiro-cyclopropyl substituent, R4 is -H or -F, and R5 is -H, methyl, -CI or -Br, Formula II wherein R1 is -H, ethyl-, isopropyl-, cyclopropyl-, methyl- or methoxy-, R4 is -H or -F, and "Y" is: (a) -CH2-; (b) -CR6H-0-CR7R8-, wherein R6, R7, and R8 are independently - H or methyl; (c) -CR6H-N(R9)-CR7R8-, wherein R6, R7, and R8 are independently -H or methyl; (d) -CH2-C(R9)(R10)-C(R7)(R8)-, wherein R7, R8, R9 and R10 are independently - H or -methyl, or both R7 and R8 are -F, R9 and R10 are independently -H or -methyl, or both R9 and R10 are -F, or R9 and R10 taken together are (0=), which together with the carbon to which they are attached forms a carbonyl group.