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1355324-29-6

C25H28FN5O2 is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • 1355324-29-6 Structure

  • Basic information

    1. Product Name: C25H28FN5O2
    2. Synonyms:
    3. CAS NO:1355324-29-6
    4. Molecular Formula:
    5. Molecular Weight: 449.528
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 1355324-29-6.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: N/A
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: C25H28FN5O2(CAS DataBase Reference)
    10. NIST Chemistry Reference: C25H28FN5O2(1355324-29-6)
    11. EPA Substance Registry System: C25H28FN5O2(1355324-29-6)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 1355324-29-6(Hazardous Substances Data)

1355324-29-6 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 1355324-29-6 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,3,5,5,3,2 and 4 respectively; the second part has 2 digits, 2 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 1355324-29:
(9*1)+(8*3)+(7*5)+(6*5)+(5*3)+(4*2)+(3*4)+(2*2)+(1*9)=146
146 % 10 = 6
So 1355324-29-6 is a valid CAS Registry Number.

1355324-29-6Downstream Products

1355324-29-6Relevant articles and documents

Discovery of the first potent inhibitors of mutant IDH1 that lower tumor 2-HG in vivo

Popovici-Muller, Janeta,Saunders, Jeffrey O.,Salituro, Francesco G.,Travins, Jeremy M.,Yan, Shunqi,Zhao, Fang,Gross, Stefan,Dang, Lenny,Yen, Katharine E.,Yang, Hua,Straley, Kimberly S.,Jin, Shengfang,Kunii, Kaiko,Fantin, Valeria R.,Zhang, Shunan,Pan, Qiongqun,Shi, Derek,Biller, Scott A.,Su, Shinsan M.

supporting information, p. 850 - 855 (2013/01/15)

Optimization of a series of R132H IDH1 inhibitors from a high throughput screen led to the first potent molecules that show robust tumor 2-HG inhibition in a xenograft model. Compound 35 shows good potency in the U87 R132H cell based assay and ～90% tumor 2-HG inhibition in the corresponding mouse xenograft model following BID dosing. The magnitude and duration of tumor 2-HG inhibition correlates with free plasma concentration.

THERAPEUTICALLY ACTIVE COMPOSITIONS AND THEIR METHOD OF USE

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Page/Page column 99, (2012/02/02)

Provided are methods of treating a cancer characterized by the presence of a mutant allele of IDH1 comprising administering to a subject in need thereof a compound described here.

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