28711-29-7

Basic information

• Product Name: 1,2,4-TRIAZOLE-1-ACETIC ACID
• Synonyms: 2-(1,2,4-TRIAZOLE-1-YL)-ACETIC ACID;1H-1,2,4-TRIAZOLE-1-ACETIC ACID;[1,2,4]TRIAZOL-1-YL-ACETIC ACID;1,2,4-TRIAZOLE-1-ACETIC ACID;1,2,4-1H-TRIAZOLE-ACETIC ACID;AKOS MSC-0008;TIMTEC-BB SBB010156;(1H-1,2,4-Triazol-1-yl)acetic acid
• CAS NO: 28711-29-7
• Molecular Formula: C₄H₅N₃O₂
• Molecular Weight: 127.1
• Product Categories: Carboxylic Acids;Pyrazoles & Triazoles;Carboxylic Acids;Pyrazoles & Triazoles
• Mol File: 28711-29-7.mol
• Article Data: 7

Chemical Properties

• Melting Point: 201-205℃
• Boiling Point: 376.9±44.0 at 760 mmHg
• Flash Point: 181.7±28.4 °C
• Appearance: /
• Density: 1.5±0.1 g/cm³
• Vapor Pressure: 2.38E-06mmHg at 25°C
• Storage Temp.: Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
• PKA: 3.27±0.12(Predicted)
• Water Solubility: Soluble in water.
• CAS DataBase Reference: 1,2,4-TRIAZOLE-1-ACETIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 1,2,4-TRIAZOLE-1-ACETIC ACID(28711-29-7)
• EPA Substance Registry System: 1,2,4-TRIAZOLE-1-ACETIC ACID(28711-29-7)

Safety Data

• Hazard Codes: C,Xi
• HazardClass: IRRITANT
• Hazardous Substances Data: 28711-29-7(Hazardous Substances Data)

Usage

Uses

1H-1,2,4-Triazole-1-acetic acid is used to produce (1-hydroxy-1-phosphono-2-[1,2,4]triazol-1-yl-ethyl)-phosphonic acid at the temperature of 100 - 110°C. It will need reagent H3PO4, PCl3 and solvent chlorobenzene

InChI:InChI=1/C4H5N3O2/c8-4(9)1-7-3-5-2-6-7/h2-3H,1H2,(H,8,9)/p-1

Upstream product

• 56563-02-1 2-(1H-1,2,4-triazol-1-yl)acetohydrazide 
• 106535-16-4 [1,2,4]triazol-1-yl-acetic acid methyl ester 
• 288-88-0 1,2,4-Triazole 
• 79-11-8 chloroacetic acid 
• 56563-01-0 ethyl 2-(1H-1,2,4-triazol-1-yl)acetate 

Downstream Products

• 56563-01-0 ethyl 2-(1H-1,2,4-triazol-1-yl)acetate 
• 1355324-29-6 C₂₅H₂₈FN₅O₂ 
• 1221878-02-9 (2S,4R)-1-(2-(1H-1,2,4-triazol-1-yl)acetyl)-4-(4-fluorobenzyl)-N-(4-(4-fluorophenoxy)phenyl)pyrrolidine-2-carboxamide 

Relevant articles and documents

Synthesis method of 2-(1H-1,2,4-triazole-1-ethy)acetic acid

The invention relates to a synthesis method of 2-(1H-1,2,4-triazole-1-ethy)acetic acid, and mainly solves the technical problem that no suitable industrial synthesis method exists at present. The preparation method comprises the following two steps: first

Synthesis of N- and C-azolyl-substituted pyrazolo[1,5-a]pyrimidines by recyclization of pyrimidinium salts

We studied the reaction of 2-(ethoxycarbonyl)methyl-1,4,6-trimethylpyrimidinium iodide with hydrazides of N-azolyl- and C-pyrazolyl-substituted carboxylic acids, which were synthesized by reacting the respective esters with hydrazine hydrate. This reaction was shown to result in recyclization and formation of ethyl 2-(pyrazolylalkyl)- and 2-(azolylalkyl)-5,7-dimethylpyrazolo[1,5-a]pyrimidine- 3-carboxylates. Besides pyrazolopyrimidines, the separation of reaction mixture provided in some cases also another recyclization product, 2-hydroxy-5,7-dimethylpyrazolo[1,5-a]pyrimidine.

Efficient synthesis and in vitro antifungal activity of 1H-benzimidazol-1-yl acetates/propionates containing 1H-1,2,4-triazole moiety

A series of novel 1H-benzimidazol-1-yl acetates and 1H-benzimidazol-1-yl propionates containing 1H-1,2,4-triazole moiety were synthesized under microwave irradiation by multi-step reactions, in yields of 87-94%. Their in vitro antifungal activities against Botrytis cinerea and Sclerotinia sclerotiorum were evaluated by mycelial growth rate method. All the target compounds exhibit high activities against B. cinerea with the EC50 values of 7.96-21.74 μg/mL, higher than that of carbendazim.