28711-29-7

Usage

Uses

Used in Pharmaceutical Industry:
1,2,4-Triazole-1-acetic acid is used as a key intermediate in the synthesis of pharmaceuticals for its ability to form stable and bioactive molecules. Its presence in the molecular structure can contribute to the development of drugs with improved pharmacokinetic and pharmacodynamic properties.
Used in Agrochemical Industry:
In the agrochemical industry, 1,2,4-Triazole-1-acetic acid is utilized as a building block for the creation of novel compounds with pesticidal properties. Its incorporation into agrochemicals can lead to the development of more effective and environmentally friendly products.
Used in Specialty Chemicals:
1,2,4-Triazole-1-acetic acid is also employed in the synthesis of specialty chemicals, such as corrosion inhibitors, dyes, and other performance-enhancing additives. Its unique chemical structure allows it to impart specific properties to these products, making them suitable for various applications.
Specific Application:
1,2,4-Triazole-1-acetic acid is used in the production of (1-hydroxy-1-phosphono-2-[1,2,4]triazol-1-yl-ethyl)-phosphonic acid, a compound synthesized at temperatures ranging from 100 to 110°C. This process requires the use of reagents such as H3PO4, PCl3, and the solvent chlorobenzene. This specific application highlights the versatility of 1,2,4-Triazole-1-acetic acid in the synthesis of complex and potentially valuable chemical entities.

InChI:InChI=1/C4H5N3O2/c8-4(9)1-7-3-5-2-6-7/h2-3H,1H2,(H,8,9)/p-1

Upstream product

• 56563-01-0 ethyl 2-(1H-1,2,4-triazol-1-yl)acetate 
• 288-88-0 1,2,4-Triazole 
• 79-11-8 chloroacetic acid 
• 56563-02-1 2-(1H-1,2,4-triazol-1-yl)acetohydrazide 
• 106535-16-4 [1,2,4]triazol-1-yl-acetic acid methyl ester 

Downstream Products

• 62119-67-9 N-(3,4-dichloro-benzenesulfonyl)-N-(2-oxo-3-[1,2,4]triazol-1-yl-2H-chromen-7-yl)-acetamide 
• 1222197-02-5 (2S,4R)-1-(2-(1H-1,2,4-triazol-1-yl)acetyl)-4-cyano-N-(4-(4-fluorophenoxy)phenyl)pyrrolidine-2-carboxamide 
• 338418-54-5 2-((1H-1,2,4-triazol-1-yl)methyl)-1H-benzimidazole 
• 1221878-02-9 (2S,4R)-1-(2-(1H-1,2,4-triazol-1-yl)acetyl)-4-(4-fluorobenzyl)-N-(4-(4-fluorophenoxy)phenyl)pyrrolidine-2-carboxamide 
• 56563-01-0 ethyl 2-(1H-1,2,4-triazol-1-yl)acetate 
• 1355324-29-6 C₂₅H₂₈FN₅O₂ 

Relevant academic research and scientific papers

Synthesis method of 2-(1H-1,2,4-triazole-1-ethy)acetic acid

The invention relates to a synthesis method of 2-(1H-1,2,4-triazole-1-ethy)acetic acid, and mainly solves the technical problem that no suitable industrial synthesis method exists at present. The preparation method comprises the following two steps: first

PROTEIN KINASE INHIBITORS

A compound of formula (I), wherein R3, R4, G, B, M, and Z are as defined in the claims, and pharmaceutically acceptable salts thereof are disclosed. The compounds of formula (I) possess utility as FGFR inhibitors and are useful in the treatment of a condition, where FGFR kinase inhibition is desired, such as cancer.

Synthesis of N- and C-azolyl-substituted pyrazolo[1,5-a]pyrimidines by recyclization of pyrimidinium salts

We studied the reaction of 2-(ethoxycarbonyl)methyl-1,4,6-trimethylpyrimidinium iodide with hydrazides of N-azolyl- and C-pyrazolyl-substituted carboxylic acids, which were synthesized by reacting the respective esters with hydrazine hydrate. This reaction was shown to result in recyclization and formation of ethyl 2-(pyrazolylalkyl)- and 2-(azolylalkyl)-5,7-dimethylpyrazolo[1,5-a]pyrimidine- 3-carboxylates. Besides pyrazolopyrimidines, the separation of reaction mixture provided in some cases also another recyclization product, 2-hydroxy-5,7-dimethylpyrazolo[1,5-a]pyrimidine.

PROTEIN KINASE INHIBITORS

A compound of formula (I), wherein R3, R4, G, B, M, and Z are as defined in the claims, and pharmaceutically acceptable salts thereof are disclosed. The compounds of formula (I) possess utility as FGFR inhibitors and are useful in the treatment of a condition, where FGFR kinase inhibition is desired, such as cancer.

Efficient synthesis and in vitro antifungal activity of 1H-benzimidazol-1-yl acetates/propionates containing 1H-1,2,4-triazole moiety

A series of novel 1H-benzimidazol-1-yl acetates and 1H-benzimidazol-1-yl propionates containing 1H-1,2,4-triazole moiety were synthesized under microwave irradiation by multi-step reactions, in yields of 87-94%. Their in vitro antifungal activities against Botrytis cinerea and Sclerotinia sclerotiorum were evaluated by mycelial growth rate method. All the target compounds exhibit high activities against B. cinerea with the EC50 values of 7.96-21.74 μg/mL, higher than that of carbendazim.

Synthesis and properties of 1-dinitromethyl-3-R-1,2,4-triazoles

Reductive denitration of 1-trinitromethyl-3-R-1,2,4-triazoles by KI or NH2OH followed by the treatment of the formed 1-dinitromethyl-3-R-1, 2,4-triazoles salts with sulfuric acid yielded dinitromethyl compounds (R = H, N3, Cl, NO2), sufficiently strong CH-acids (pKa 1.37-0.12) whose typical reactions are similar to those of gem-dinitrocompounds from the aliphatic series. The spectral data and the analysis of correlation relations between pKa of 1-dinitromethyl-3-R-1,2,4-triazoles and the substituent constants confirm that their structure is analogous to that of the majority of compounds belonging to the mentioned series. Nauka/Interperiodica 2007.

BIOMIMETIC, CHEMICAL, AND SPECTROSCOPIC EVALUATIONS FOR THE RADIOSENSITIZING POTENTIAL OF N1- AND N2-SUBSTITUTED DERIVATIVES OF 3-NITRO-1,2,4-TRIAZOLE TOWARD HYPOXIC CELLS IN THE RADIOTHERAPY: REMARKABLY DIFFERENT SUBSTITUTION EFFECT

N1- and N2-derivatives of 3-nitro-1,2,4-triazole (3-NTR) were subjected to the non-biological evaluation methods involving biomimetic, chemical, and spectroscopic procedures for the radiosensitizing potential.Consequently, the N1-derivatives of 3-NTR were suggested to be more promising radiosensitizers to hypoxic cells in vivo than the N2-derivatives.