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CAS

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1356476-38-4

Tert-butyl 2-methylidene-7-azaspiro[3.5]nonane-7-carboxylate is a chemical compound with the molecular formula C14H23NO2. It is a derivative of the spiro compounds, which have a bicyclic structure. This specific compound contains a tert-butyl group, a methylidene group, and a carboxylate functional group. It is commonly used in organic synthesis and medicinal chemistry as a building block for the preparation of various pharmaceuticals and biologically active molecules. Its unique structure and functional groups make it a valuable precursor for the synthesis of complex organic compounds.

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  • 1356476-38-4 Structure

  • Basic information

    1. Product Name: tert-butyl 2-methylidene-7-azaspiro[3.5]nonane-7-carboxylate
    2. Synonyms: tert-butyl 2-methylidene-7-azaspiro[3.5]nonane-7-carboxylate;tert-Butyl 2-methylene-7-azaspiro[3.5]nonane-7-carboxylate
    3. CAS NO:1356476-38-4
    4. Molecular Formula: C14H23NO2
    5. Molecular Weight: 237.33792
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 1356476-38-4.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: 318.0±42.0 °C(Predicted)
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: 1.04±0.1 g/cm3(Predicted)
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. PKA: -0.76±0.20(Predicted)
    10. CAS DataBase Reference: tert-butyl 2-methylidene-7-azaspiro[3.5]nonane-7-carboxylate(CAS DataBase Reference)
    11. NIST Chemistry Reference: tert-butyl 2-methylidene-7-azaspiro[3.5]nonane-7-carboxylate(1356476-38-4)
    12. EPA Substance Registry System: tert-butyl 2-methylidene-7-azaspiro[3.5]nonane-7-carboxylate(1356476-38-4)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 1356476-38-4(Hazardous Substances Data)

1356476-38-4 Usage

Uses

Used in Organic Synthesis:
Tert-butyl 2-methylidene-7-azaspiro[3.5]nonane-7-carboxylate is used as a building block in organic synthesis for the preparation of complex organic compounds. Its unique structure and functional groups make it a valuable precursor for the synthesis of various molecules.
Used in Medicinal Chemistry:
In the pharmaceutical industry, tert-butyl 2-methylidene-7-azaspiro[3.5]nonane-7-carboxylate is used as a key intermediate in the synthesis of biologically active molecules and pharmaceuticals. Its versatility and reactivity contribute to the development of new drugs and therapeutic agents.

Check Digit Verification of cas no

The CAS Registry Mumber 1356476-38-4 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,3,5,6,4,7 and 6 respectively; the second part has 2 digits, 3 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 1356476-38:
(9*1)+(8*3)+(7*5)+(6*6)+(5*4)+(4*7)+(3*6)+(2*3)+(1*8)=184
184 % 10 = 4
So 1356476-38-4 is a valid CAS Registry Number.

1356476-38-4Relevant articles and documents

Stereoselective Diboration of Spirocyclobutenes: A Platform for the Synthesis of Spirocycles with Orthogonal Exit Vectors

Nóvoa, Luis,Trulli, Laura,Parra, Alejandro,Tortosa, Mariola

supporting information, p. 11763 - 11768 (2021/04/26)

The diastereo- and enantioselective diboration of spirocyclobutenes provides a platform for the rapid preparation of a wide variety of chiral spirocyclic building blocks. The chemoselective functionalization of the carbon-boron bond in the products, including a stereospecific sp3-sp2 Suzuki–Miyaura cross-coupling reaction, provides a powerful tool to control the directionality and the nature of the exit vectors in the spirocyclic framework.

IRAK DEGRADERS AND USES THEREOF

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Paragraph 00512; 001093-001095, (2021/06/26)

The present invention provides compounds, compositions thereof, and methods of using the same.

Discovery of novel spirocyclic inhibitors of fatty acid amide hydrolase (FAAH). Part 1: Identification of 7-azaspiro[3.5]nonane and 1-oxa-8-azaspiro[4. 5]decane as lead scaffolds

Meyers, Marvin J.,Long, Scott A.,Pelc, Matthew J.,Wang, Jane L.,Bowen, Scott J.,Walker, Mark C.,Schweitzer, Barbara A.,Madsen, Heather M.,Tenbrink, Ruth E.,McDonald, Joseph,Smith, Sarah E.,Foltin, Susan,Beidler, David,Thorarensen, Atli

scheme or table, p. 6538 - 6544 (2011/12/04)

Herein we report the identification of two new fatty acid amide hydrolase (FAAH) inhibitor lead series with FAAH kinact/Ki potency values greater than 1500 M-1s-1. The two novel spirocyclic cores, 7-azaspiro[3.5]nonane and 1-oxa-8-azaspiro[4.5]decane, clearly distinguished themselves from the other spirocyclic cores on the basis of their superior potency for FAAH. Lead compounds from these two series have suitable FAAH potency and selectivity for additional medicinal chemistry optimization.

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