tert-butyl 2-methylidene-7-azaspiro[3.5]nonane-7-carboxylate

Base Information

• Chemical Name: tert-butyl 2-methylidene-7-azaspiro[3.5]nonane-7-carboxylate
• CAS No.: 1356476-38-4
• Molecular Formula: C14H23NO2
• Molecular Weight: 237.34
• Hs Code.: 2933998090
• Mol file: 1356476-38-4.mol

Synonyms:tert-butyl 2-methylidene-7-azaspiro[3.5]nonane-7-carboxylate;tert-Butyl 2-methylene-7-azaspiro[3.5]nonane-7-carboxylate

Chemical Property of tert-butyl 2-methylidene-7-azaspiro[3.5]nonane-7-carboxylate

Chemical Property:

• Boiling Point: 318.0±42.0 °C(Predicted)
• PKA: -0.76±0.20(Predicted)
• PSA: 29.54000
• Density: 1.04±0.1 g/cm3(Predicted)
• LogP: 3.29160

Purity/Quality:

97% ^*data from raw suppliers

tert-butyl2-methylidene-7-azaspiro[3.5]nonane-7-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of tert-butyl 2-methylidene-7-azaspiro[3.5]nonane-7-carboxylate

There total 2 articles about tert-butyl 2-methylidene-7-azaspiro[3.5]nonane-7-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

Methyltriphenylphosphonium bromide (1779-49-3) + tert-butyl 2-oxo-9-azadispiro[3.1.56.14]dodecane-9-carboxylate → tert-butyl 2-methylene-7-azaspiro[3.5]nonane-7-carboxylate (1356476-38-4)

Guidance literature:

With potassium tert-butylate; In diethyl ether; at 0 - 20 ℃; for 1h; Inert atmosphere;

DOI:10.1002/anie.202101445

Reference yield: 84.0%

Methyltriphenylphosphonium bromide (1779-49-3) + tert-butyl 2-oxo-7-azaspiro[3.5]nonane-7-carboxylate (203661-69-2) → tert-butyl 2-methylene-7-azaspiro[3.5]nonane-7-carboxylate (1356476-38-4)

Guidance literature:

Methyltriphenylphosphonium bromide; In tetrahydrofuran; at 0 ℃; for 0.5h; Inert atmosphere;

tert-butyl 2-oxo-7-azaspiro[3.5]nonane-7-carboxylate; In tetrahydrofuran; at 0 - 20 ℃; for 1h; Inert atmosphere;

Reference yield:

tert-butyl 2-methylene-7-azaspiro[3.5]nonane-7-carboxylate (1356476-38-4) → C27H31F3N2O3 (1346556-74-8)

Guidance literature:

Multi-step reaction with 3 steps

1: dihydrogen peroxide

2: Dess-Martin periodane / dichloromethane

3: potassium tert-butylate / tetrahydrofuran

With potassium tert-butylate; dihydrogen peroxide; Dess-Martin periodane; In tetrahydrofuran; dichloromethane;

DOI:10.1016/j.bmcl.2011.08.055

upstream raw materials:

Methyltriphenylphosphonium bromide

tert-butyl 2-oxo-7-azaspiro[3.5]nonane-7-carboxylate

Downstream raw materials:

tert-butyl 2-formyl-7-azaspiro[3.5]nonane-7-carboxylate

C₂₇H₃₁F₃N₂O₃

C₂₇H₂₈F₃N₅O₂

C₂₇H₃₃F₃N₂O₃