- Photochemistry of β-Methoxystyrene in the Presence of Nitroarenes. Unusual Products Formation
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The irradiation of β-methoxystyrene in the presence of nitroarenes gave un unusual product deriving from dimerization and oxidation of the starting material.In the reaction mixture also an amide was identified.
- D'Auria, Maurizio
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- Efficient and Mild Ullmann-Type N-Arylation of Amides, Carbamates, and Azoles in Water
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A simple, sustainable, efficient, mild, and low-cost protocol was developed for d-glucose-assisted Cu-catalyzed Ullmann reactions in water for amides, carbamates, and nitrogen-containing heterocycles. The reaction was compatible with diverse aryl/heteroaryl iodides, giving highly substituted pyridine, indole, or indazole rings. This method offers an attractive alternative to existing protocols, because the reaction proceeds in aqueous media, occurs at or near ambient temperature, and provides the N-arylated products in good to high yields.
- Bollenbach, Maud,Aquino, Pedro G. V.,de Araújo-Júnior, Jo?o Xavier,Bourguignon, Jean-Jacques,Bihel, Frédéric,Salomé, Christophe,Wagner, Patrick,Schmitt, Martine
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supporting information
p. 13676 - 13683
(2017/10/10)
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- Acidylation method of amine
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The invention discloses an acidylation method of amine.The method includes the following steps that amine derivatives, hydrazide derivatives, organic peroxide and a catalyst are dissolved in a solvent and react at the temperature of 40-80 DEG C, and amide derivatives are obtained.The amide derivatives and hydrazide derivatives serve as initiators, the raw materials are easy to obtain and the number of varieties is large.Products obtained through the method are diverse in type, can be directly used and can also be used for other further reactions.The method is mild in reaction condition, simple in reaction operation and post-processing process, high in product yield and suitable for scale production.
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Paragraph 0027
(2016/10/10)
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- Copper catalyzed N-arylation between aryl halides and nitriles in water: An efficient tandem synthesis of benzanilides
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A series of benzanilide compounds were synthesized through copper-catalyzed tandem reactions. With the assistance of ionic liquid as phase transfer catalyst, aryl halides, and nitriles underwent a hydrolysis/coupling pathway to form benzanilides in water. Advantages of this reaction include the use of water as the environmental friendly solvent, short reaction time, and the tolerance of various functional groups. A proposed mechanism based on control experiments is also presented.
- Wang, Jichao,Yin, Xinchi,Wu, Jun,Wu, Datong,Pan, Yuanjiang
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p. 10463 - 10469
(2013/11/19)
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- An improved protocol for synthesis of N-arylamides and benzoxazoles by the copper-catalyzed reaction of aryl halides with nitriles
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An improved protocol for the synthesis of N-arylamides and benzoxazoles by the copper-catalyzed reaction of aryl halides with nitriles has been developed. Use of acetaldoxime as the hydrolysis reagent instead of H2O facilitates the operation of the reaction. The significantly decreased amount of nitriles, along with use of weak base K2CO3 instead of strong base KOH, makes this transformation atom-efficient and environmentally benign. A variety of N-arylamides and benzoxazole derivatives can be synthesized according to this approach.
- Zhang, Dong-Xue,Xiang, Shi-Kai,Hu, Hao,Tan, Wen,Feng, Chun,Wang, Bi-Qin,Zhao, Ke-Qing,Hu, Ping,Yang, Hua
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p. 10022 - 10029
(2013/11/06)
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- Amidation of aryl halides catalyzed by the efficient and recyclable Cu 2O nanoparticles
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Cu2O nanoparticles/DMEDA (N,N′-dimethylethylenediamine) was proved to be an efficient catalyst system for amidation of aryl halides under mild condition. This method displayed excellent selectivity and the catalyst was recyclable without loss of activity. The low cost, simple operation and excellent yields make this approach attractive for industrial applications. Cu2O nanoparticles/DMEDA (N,N′-dimethylethylenediamine) was proved to be an efficient catalyst system for amidation of aryl halides under mild condition. This method displayed excellent selectivity and the catalyst was recyclable without loss of activity. The low cost, simple operation and excellent yields make this approach attractive for industrial applications. Copyright
- Yao, Zijian,Wei, Xianwen
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experimental part
p. 2260 - 2268
(2011/10/12)
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- Microwave-promoted conversion of heterocyclic amines to corresponding amides under solvent-free conditions
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An array of heterocyclic amides was synthesized efficiently by combining corresponding amines and benzoyl chloride in one-pot under microwave irradiation. The reaction times were shorter, yields were higher. What is more, the regioselectivity was excellent, which made the protocol support us an entry to selective protection of diverse amino groups.
- Li, Yanqiu,Wang, Yulu,Wang, Jinye
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p. 251 - 256
(2008/03/14)
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- Copper-catalyzed N-arylation of aryl iodides with benzamides or nitrogen heterocycles in the presence of ethylenediamine
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The copper-catalyzed N-arylation of benzamides or nitrogen heterocycles was carried out with catalytic CuI (10 mol%) in the presence of ethylenediamine (10 mol%) as a ligand and K3PO4 or Cs2CO3 as a base under mild conditions.
- Kang, Suk-Ku,Kim, Doo-Hwan,Park, Joung-Nam
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p. 427 - 430
(2007/10/03)
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