136005-64-6Relevant articles and documents
ACETAMIDO DERIVATIVES AS DNA POLYMERASE THETA INHIBITORS
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Paragraph 0244, (2020/08/22)
Disclosed herein are certain acetamido derivatives that are DNA Polymerase Theta (Polθ) inhibitors of Formula (I). Also, disclosed are pharmaceutical compositions comprising such compounds and methods of treating diseases treatable by inhibition of Polθ such as cancer, including homologous recombination (HR) deficient cancers.
Dirhodium(II)-catalyzed [3 + 2] cycloaddition of N-arylaminocyclopropane with alkyne derivatives
Liu, Wentong,Kuang, Yi,Wang, Zhifan,Zhu, Jin,Wang, Yuanhua
supporting information, p. 542 - 550 (2019/03/08)
Dirhodium(II) complex-catalyzed [3 + 2] reactions between N-arylaminocyclopropanes and alkyne derivatives are described. The cycloaddition products proved to be versatile synthetic intermediates. trans-Cyclic β-amino acids and derivatives thereof can be c
Air oxidation of N-cyclopropylanilines
Blackburn, Anthony,Bowles, Daniel M.,Curran, Timothy T.,Kim, Hui
, p. 1855 - 1863 (2012/04/10)
Air oxidation of N-cyclopropylanilines was shown to occur under either ambient conditions or accelerated conditions (warming or shining light) in an open container. A subsequent fragmentation resulted in formation of the corresponding acetamide. While potential mechanisms have been previously proposed, simple aerobic oxidation to β-hydroxy-propionamides in the absence of a radical promoter has not been previously reported. Copyright Taylor & Francis Group, LLC.
