351-83-7

Basic information

• Product Name: 4-Fluoroacetanilide
• Synonyms: 4'-FLUOROACETANILIDE;4-FLUOROACETANILIDE;1-ACETAMIDO-4-FLUOROBENZENE;N1-(4-FLUOROPHENYL)ACETAMIDE;N-(4-FLUOROPHENYL)ACETAMIDE;P-FLUOROACETANILIDE;4’-fluoro-acetanilid;Acetamide, N-(4-fluorophenyl)-
• CAS NO: 351-83-7
• Molecular Formula: C₈H₈FNO
• Molecular Weight: 153.15
• EINECS: 206-515-9
• Product Categories: Aromatic Carboxylic Acids, Amides, Anilides, Anhydrides & Salts;Anilines, Amides & Amines;Fluorine Compounds
• Mol File: 351-83-7.mol
• Article Data: 147

Chemical Properties

• Melting Point: 153-155 °C(lit.)
• Boiling Point: 300.6±25.0 °C(Predicted)
• Appearance: /
• Density: 1.1655 (estimate)
• Solubility: soluble in Methanol
• PKA: 14.10±0.70(Predicted)
• Water Solubility: practically insoluble
• BRN: 2208090
• CAS DataBase Reference: 4-Fluoroacetanilide(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Fluoroacetanilide(351-83-7)
• EPA Substance Registry System: 4-Fluoroacetanilide(351-83-7)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-37/39-24/25-36-37
• WGK Germany: 2
• RTECS: AE2977000
• HazardClass: IRRITANT
• Hazardous Substances Data: 351-83-7(Hazardous Substances Data)

Usage

Chemical Properties

white to off-white fluffy crystalline powder

InChI:InChI=1/C8H8FNO/c1-6(11)10-8-4-2-7(9)3-5-8/h2-5H,1H3,(H,10,11)

Upstream product

• 701-30-4 1-tert-butyl-4-fluorobenzene 
• 75-05-8 acetonitrile 
• 371-40-4 4-fluoroaniline 
• 10387-40-3 potassium thioacetate 
• 459-47-2 1-ethyl-4-fluorobenzene 
• 64-19-7 acetic acid 
• 350-46-9 4-Fluoronitrobenzene 
• 405-99-2 para-fluorostyrene 
• 75-36-5 acetyl chloride 
• 108-24-7 acetic anhydride 
• 14040-11-0 tungsten hexacarbonyl 
• 616-38-6 carbonic acid dimethyl ester 
• 824-75-9 p-fluorobenzamide 
• 507-09-5 tiolacetic acid 

Downstream Products

• 38962-61-7 5-Amino-2-fluorbenzolsulfonsaeure 
• 49579-56-8 2-acetamido-5-fluorobenzoic acid 
• 896429-57-5 5-fluoro-2-(1H-pyrrol-1-yl)aniline 
• 674284-49-2 1-(4-fluoro-2-nitrophenyl)-1H-pyrrole 
• 1017403-67-6 (2-chloro-6-fluoroquinolin-3-yl)methanol 
• 728005-98-9 N-(4-fluoro-phenyl)-N-prop-2-ynylacetamide 
• 405-67-4 ethyl-(4-fluoro-phenyl)-amine 
• 393-42-0 2-amino-5-fluorobenzenesulfonic acid 
• 749920-54-5 2-chloro-6-fluoro-quinoline-3-carboxaldehyde 
• 1003-98-1 2-bromo-4-fluoroaniline 
• 158979-25-0 N-Acetyl-4-fluoro-2',5'-dimethyldiphenylamine 
• 36035-49-1 N-(4-fluoro-phenyl)-N-methyl-acetamide 
• 101493-79-2 C₉H₇⁽²⁾H₃FNO 
• 3110-67-6 4-Fluor-N-brom-acetanilid 

Relevant articles and documents

A Facile Regioselective Aromatic Fluorination of N-Aryl-N-hydroxyamides with Diethylaminosulfur Trifluoride (DAST)

Treatment of N-aryl-N-hydroxyamides with diethylaminosulfur trifluoride (DAST) under conventional reaction conditions results in removal of the hydroxy function and introduction of a fluorine atom at the para position of the aromatic ring, in high yield.

Efficient nitriding reagent and application thereof

The invention discloses an efficient nitriding reagent and application thereof, wherein the nitriding reagent comprises nitrogen oxide, an active agent, a reducing agent and an organic solvent. By applying the nitriding reagent, nitrogen-containing compounds such as amide, nitrile and the like can be produced, and the method is simple in condition, low in waste discharge amount and simple in reaction equipment.

Method for catalyzing one-pot hydrogenation and amidation of nitroaromatic hydrocarbon and carboxylic acid by visible light

The invention discloses a method for catalyzing one-pot hydrogenation and amidation reaction of nitroaromatic hydrocarbon and carboxylic acid by visible light. The method comprises the following steps: preparing Pt nanoparticles uniformly dispersed on an N-doped titanium dioxide/titanium carbide (MXene) heterojunction as a photocatalyst (3% Pt/N-TiO2/Ti3C2), and applying the catalyst to a cascade reaction of an aromatic nitro compound and carboxylic acid to prepare an amide product. The 3% Pt/N-TiO2/Ti3C2 has excellent tandem hydrogenation and amidation activity and chemical selectivity of an aromatic nitro compound and carboxylic acid under the irradiation of visible light. The excellent catalytic performance of 3% Pt/N-TiO2/Ti3C2 is attributed to the close contact of TiO2 and conductive Ti3C2, and the separation efficiency of photo-induced electrons and holes is improved through charge short-range directional transmission. The preparation method of the catalyst is simple and easy to operate, the catalyst can be used for photocatalytic efficient one-pot hydrogenation and amidation reactions, the reaction conditions are mild, and the catalyst is easy to recycle.