13633-84-6

Basic information

• Product Name: 2-methylphenyl prop-2-enoate
• CAS NO: 13633-84-6
• Molecular Formula: C₁₀H₁₀O₂
• Molecular Weight: 162.1852
• Mol File: 13633-84-6.mol

Chemical Properties

• Boiling Point: 253.9°C at 760 mmHg
• Flash Point: 99.4°C
• Density: 1.046g/cm³
• Vapor Pressure: 0.0178mmHg at 25°C
• Refractive Index: 1.515
• CAS DataBase Reference: 2-methylphenyl prop-2-enoate(CAS DataBase Reference)
• NIST Chemistry Reference: 2-methylphenyl prop-2-enoate(13633-84-6)
• EPA Substance Registry System: 2-methylphenyl prop-2-enoate(13633-84-6)

Safety Data

• Hazardous Substances Data: 13633-84-6(Hazardous Substances Data)

Upstream product

• 123-31-9 hydroquinone 
• 95-48-7 ortho-cresol 
• 814-68-6 acryloyl chloride 
• 79-10-7 acrylic acid 

Downstream Products

• 1620141-43-6 (R)-o-tolyl 4-nitro-4-(phenylsulfonyl)pentanoate 

Relevant articles and documents

Acid- And base-switched palladium-catalyzed γ-C(sp3)-H alkylation and alkenylation of neopentylamine

The functionalization of remote unactivated C(sp3)-H and the reaction selectivity are among the core pursuits for transition-metal catalytic system development. Herein, we report Pd-catalyzed γ-C(sp3)-H-selective alkylation and alkenylation with removable 7-azaindole as a directing group. Acid and base were found to be the decisive regulators for the selective alkylation and alkenylation, respectively, on the same single substrate under otherwise the same reaction conditions. Various acrylates were compatible for the formation of C(sp3)-C(sp3) and C(sp3)-C(sp2) bonds. The alkenylation protocol could be further extended to acrylates with natural product units and α,β-unsaturated ketones. The preliminary synthetic manipulation of the alkylation and alkenylation products demonstrates the potential of this strategy for structurally diverse aliphatic chain extension and functionalization. Mechanistic experimental studies showed that the acidic and basic catalytic transformations shared the same six-membered dimer palladacycle.