1364933-59-4

Basic information

• Product Name: JWH 412
• Synonyms: JWH 412;(4-fluoronaphthalen-1-yl)-(1-pentylindol-3-yl)methanone
• CAS NO: 1364933-59-4
• Molecular Formula: C24H22FNO
• Molecular Weight: 359.4359832
• Product Categories: Aromatics, Heterocycles, Indole Derivatives, Neurochemicals, Pharmaceuticals, Intermediates & Fine Chemicals
• Mol File: 1364933-59-4.mol

Chemical Properties

• Boiling Point: 539.3±30.0 °C(Predicted)
• Appearance: /
• Density: 1.14±0.1 g/cm3(Predicted)
• CAS DataBase Reference: JWH 412(CAS DataBase Reference)
• NIST Chemistry Reference: JWH 412(1364933-59-4)
• EPA Substance Registry System: JWH 412(1364933-59-4)

Safety Data

• Hazardous Substances Data: 1364933-59-4(Hazardous Substances Data)

Usage

Uses

Used in Research and Forensic Applications:
JWH 412 is used as a research compound for studying the interactions and effects of cannabinoids on the CB1 and CB2 receptors. Its enhanced binding affinity compared to other cannabinoids makes it a valuable tool in understanding the mechanisms of cannabinoid action and developing potential therapeutic applications.
Used in Pharmaceutical Development:
JWH 412's high affinity for cannabinoid receptors makes it a potential candidate for the development of new pharmaceuticals targeting these receptors. It can be used in the design and synthesis of novel cannabinoid-based drugs for various medical conditions, including pain management, inflammation, and neurological disorders.
Used in Analytical Chemistry:
The identification of JWH 412 in 'herbal mixtures' highlights its use in analytical chemistry for the detection and analysis of synthetic cannabinoids in various samples. This can be crucial in forensic investigations and the regulation of these substances.
Used in Toxicology Studies:
JWH 412 can be employed in toxicology research to investigate the potential risks and side effects associated with the use of synthetic cannabinoids. This information is essential for understanding the safety profile of these compounds and informing regulatory decisions.

Upstream product

• 59529-21-4 1-pentyl-1H-indole 
• 56886-72-7 4-fluoro-1-naphthoic acid chloride 
• 573-03-5 4-fluoro-1-naphthoic acid 

Relevant articles and documents

Synthesis and pharmacology of 1-alkyl-3-(1-naphthoyl)indoles: Steric and electronic effects of 4- and 8-halogenated naphthoyl substituents

To develop SAR at both the cannabinoid CB1 and CB2 receptors for 3-(1-naphthoyl)indoles bearing moderately electron withdrawing substituents at C-4 of the naphthoyl moiety, 1-propyl and 1-pentyl-3-(4-fluoro, chloro, bromo and iodo-1-naphthoyl) derivatives were prepared. To study the steric and electronic effects of substituents at the 8-position of the naphthoyl group, the 3-(4-chloro, bromo and iodo-1-naphthoyl)indoles were also synthesized. The affinities of both groups of compounds for the CB1 and CB2 receptors were determined and several of them were evaluated in vivo in the mouse. The effects of these substituents on receptor affinities and in vivo activity are discussed and structure-activity relationships are presented. Although many of these compounds are selective for the CB2 receptor, only three JWH-423, 1-propyl-3-(4-iodo-1-naphthoyl)indole, JWH-422, 2-methyl-1-propyl-3-(4-iodo-1-naphthoyl)indole, the 2-methyl analog of JWH-423 and JWH-417, 1-pentyl-3-(8-iodo-1-naphthoyl)indole, possess the desirable combination of low CB1 affinity and good CB2 affinity.