JWH 412

Base Information

• Chemical Name: JWH 412
• CAS No.: 1364933-59-4
• Molecular Formula: C24H22FNO
• Molecular Weight: 359.44
• Mol file: 1364933-59-4.mol

Synonyms:JWH 412

Chemical Property of JWH 412

Chemical Property:

• Boiling Point: 539.3±30.0 °C(Predicted)
• PSA: 22.00000
• Density: 1.14±0.1 g/cm3(Predicted)
• LogP: 6.35480

Purity/Quality:

99% ^*data from raw suppliers

JWH412 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Description: JWH 412 is a positional isomer of AM2201 that was identified in the ‘herbal mixture’ XoXo. The substitution of hydrogen against fluorine in the 4-position of the naphthyl moiety enhances the binding affinity to the central cannabinoid (CB1) receptor compared to the unsubstituted JWH 018. JWH 412 demonstrates Ki values of 7.2 and 3.2 nM at CB1 and peripheral CB2 receptors, respectively. This product is intended for research and forensic purposes.
• Uses: JWH 412 is a naphthoylindoles acting on cannabinoid receptors identified based on their fragmentation patterns under ESI-QTOFMS. JWH 412 is a positional isomer of AM2201 that was identified in the ‘herbal mixture’ XoXo. The substitution of hydrogen against fluorine in the 4-position of the naphthyl moiety enhances the binding affinity to the central cannabinoid (CB1) receptor compared to the unsubstituted JWH 018. JWH 412 demonstrates Ki values of 7.2 and 3.2 nM at CB1 and peripheral CB2 receptors, respectively. This product is intended for research and forensic purposes.[Cayman Chemical]

Technology Process of JWH 412

There total 2 articles about JWH 412 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 10.0%

1-pentyl-1H-indole (59529-21-4) + 4-fluoro-1-naphthoic acid chloride (56886-72-7) → (4-fluoro-1-naphthalenyl)(1-pentyl-1H-indol-3-yl)methanone (1364933-59-4)

Guidance literature:

1-pentyl-1H-indole; With dimethylaluminum chloride; In hexane; dichloromethane; at 0 ℃; for 0.5h; Inert atmosphere;

4-fluoro-1-naphthoic acid chloride; In hexane; dichloromethane; at 0 - 20 ℃; Inert atmosphere;

DOI:10.1016/j.bmc.2012.01.038

Reference yield:

4-fluoro-1-naphthoic acid (573-03-5) → (4-fluoro-1-naphthalenyl)(1-pentyl-1H-indol-3-yl)methanone (1364933-59-4)

Guidance literature:

Multi-step reaction with 2 steps

1.1: thionyl chloride / 2 h / Inert atmosphere; Reflux

2.1: dimethylaluminum chloride / hexane; dichloromethane / 0.5 h / 0 °C / Inert atmosphere

2.2: 0 - 20 °C / Inert atmosphere

With thionyl chloride; dimethylaluminum chloride; In hexane; dichloromethane; 2.1: Friedel-Crafts reaction / 2.2: Friedel-Crafts reaction;

DOI:10.1016/j.bmc.2012.01.038

upstream raw materials:

1-pentyl-1H-indole

4-fluoro-1-naphthoic acid chloride

4-fluoro-1-naphthoic acid