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2-Methoxy-4-nitrobenzyl alcohol is a chemical compound with the molecular formula C8H9NO4, known for its pale yellow crystalline appearance and strong odor. It is soluble in organic solvents such as ethanol and methanol and is commonly used as a reagent in organic synthesis and a precursor in the production of pharmaceuticals and agrochemicals. Due to its potential to cause irritation, it should be handled with caution.

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  • 136507-14-7 Structure
  • Basic information

    1. Product Name: 2-METHOXY-4-NITROBENZYL ALCOHOL
    2. Synonyms: 2-METHOXY-4-NITROBENZYL ALCOHOL
    3. CAS NO:136507-14-7
    4. Molecular Formula: C8H9NO4
    5. Molecular Weight: 183.16
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 136507-14-7.mol
  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: 357.4 °C at 760 mmHg
    3. Flash Point: 169.95 °C
    4. Appearance: /
    5. Density: 1.317 g/cm3
    6. Vapor Pressure: 0mmHg at 25°C
    7. Refractive Index: 1.574
    8. Storage Temp.: Sealed in dry,Room Temperature
    9. Solubility: N/A
    10. CAS DataBase Reference: 2-METHOXY-4-NITROBENZYL ALCOHOL(CAS DataBase Reference)
    11. NIST Chemistry Reference: 2-METHOXY-4-NITROBENZYL ALCOHOL(136507-14-7)
    12. EPA Substance Registry System: 2-METHOXY-4-NITROBENZYL ALCOHOL(136507-14-7)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 136507-14-7(Hazardous Substances Data)

136507-14-7 Usage

Uses

Used in Pharmaceutical Industry:
2-Methoxy-4-nitrobenzyl alcohol is used as a reagent in the synthesis of various pharmaceutical compounds for its ability to facilitate the creation of complex organic molecules, contributing to the development of new medications.
Used in Agricultural Industry:
2-Methoxy-4-nitrobenzyl alcohol is used as a precursor in the production of agrochemicals, specifically for the synthesis of compounds that can be utilized in the development of pesticides or other agricultural chemicals to improve crop protection and yield.

Check Digit Verification of cas no

The CAS Registry Mumber 136507-14-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,3,6,5,0 and 7 respectively; the second part has 2 digits, 1 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 136507-14:
(8*1)+(7*3)+(6*6)+(5*5)+(4*0)+(3*7)+(2*1)+(1*4)=117
117 % 10 = 7
So 136507-14-7 is a valid CAS Registry Number.
InChI:InChI=1/C8H9NO4/c1-13-8-4-7(9(11)12)3-2-6(8)5-10/h2-4,10H,5H2,1H3

136507-14-7SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name (2-methoxy-4-nitrophenyl)methanol

1.2 Other means of identification

Product number -
Other names 2-METHOXY-4-NITROBENZYL ALCOHOL

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:136507-14-7 SDS

136507-14-7Relevant articles and documents

Development of Bioreduction Labile Protecting Groups for the 2′-Hydroxyl Group of RNA

Nakamura, Kodai,Ono, Akira,Saneyoshi, Hisao,Terasawa, Kazuma

supporting information, (2020/08/05)

Protection and deprotection of the 2′-hydroxyl group of RNAs are critical for RNA-based drug discovery. This paper reports development of a bioreduction labile protecting group of the 2′-hydroxyl group in RNA. After the reduction of the nitro group in a c

COMPOUNDS FOR TREATMENT OF CARDIAC ARRHYTHMIAS AND HEART FAILURE

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, (2019/10/19)

This disclosure concerns compounds and a method for modulating the activity of calcium ion channels, including Ca2+-induced (or Ca2+-activated) calcium release channels and conformationally coupled calcium release channels such as ryanodine receptors. Some of the compounds have a structure according to formula I, or a stereoisomer, tautomer, hydrate, solvate, prodrug, or pharmaceutically acceptable salt thereof.

PYRROLONE OR PYRROLIDINONE MELANIN CONCENTRATING HORMONE RECEPTOR-1 ANTAGONISTS

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Paragraph 00316, (2014/03/26)

The present invention provides compounds of Formula (I): as defined in the specification and compositions comprising any of such novel compounds. These compounds are melanin concentrating hormone receptor-1 (MCHR1) antagonists which may be used as medicaments.

Effects of electronics, aromaticity, and solvent polarity on the rate of azaquinone-methide-mediated depolymerization of aromatic carbamate oligomers

Robbins, Jessica S.,Schmid, Kyle M.,Phillips, Scott T.

supporting information, p. 3159 - 3169 (2013/06/26)

This paper uses physical-organic studies on well-defined oligomers to establish design principles for creating aromatic poly(carbamates) that depolymerize from head-to-tail in low dielectric constant environments when exposed to specific applied signals. We show that either increasing electron density or decreasing the aromaticity of aromatic repeating units in poly(carbamates) increase the overall depolymerization rate. For example, a methoxybenzene-based repeating unit provides depolymerization rates that are 143× faster than oligomers that contain a benzene-based repeating unit. Furthermore, the rate of depolymerization in the methoxybenzene-based system is tolerant to low dielectric environments, whereas the benzene-based oligomers are not.

Palladium-catalyzed direct hydroxymethylation of aryl halides and triflates with potassium acetoxymethyltrifluoroborate

Murai, Norio,Yonaga, Masahiro,Tanaka, Keigo

supporting information; experimental part, p. 1278 - 1281 (2012/04/23)

Suzuki-Miyaura cross-coupling reactions of aryl halides and triflates with potassium acetoxymethyltrifluoroborate afforded the corresponding aryl and heteroaryl methanol products in moderate to excellent yields.

Synthesis and structure-activity relationships of nitrobenzyl phosphoramide mustards as nitroreductase-activated prodrugs

Hu, Longqin,Wu, Xinghua,Han, Jiye,Chen, Lin,Vass, Simon O.,Browne, Patrick,Hall, Belinda S.,Bot, Christopher,Gobalakrishnapillai, Vithurshaa,Searle, Peter F.,Knox, Richard J.,Wilkinson, Shane R.

scheme or table, p. 3986 - 3991 (2011/08/06)

A series of nitrobenzyl phosphoramide mustards and their analogs was designed and synthesized to explore their structure-activity relationships as substrates of nitroreductases from Escherichia coli and trypanosomes and as potential antiproliferative and antiparasitic agents. The position of the nitro group on the phenyl ring was important with the 4-nitrobenzyl phosphoramide mustard (1) offering the best combination of enzyme activity and antiproliferative effect against both mammalian and trypanosomatid cells. A preference was observed for halogen substitutions ortho to benzyl phosphoramide mustard but distinct differences were found in their SAR of substituted 4-nitrobenzyl phosphoramide mustards in E. coli nitroreductase-expressing cells and in trypanosomatids expressing endogenous nitroreductases.

INDOLINONE DERIVATIVES AND THEIR USE IN TREATING DISEASE-STATES SUCH AS CANCER

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Page/Page column 25, (2009/01/24)

The present invention encompasses compounds of general formula (1) wherein R1 to R4 are defined as in claim 1, which are suitable for the treatment of diseases characterised by excessive or abnormal cell proliferation, and their use for preparing a pharmaceutical composition having the above-mentioned properties.

Orally active CCR5 antagonists as anti-HIV-1 agents 2: Synthesis and biological activities of anilide derivatives containing a pyridine N-oxide moiety

Seto, Masaki,Aramaki, Yoshio,Imoto, Hiroshi,Aikawa, Katsuji,Oda, Tsuneo,Kanzaki, Naoyuki,Iizawa, Yuji,Baba, Masanori,Shiraishi, Mitsuru

, p. 818 - 829 (2007/10/03)

In order to develop orally active CCR5 antagonists, we investigated 1-benzoxepine derivatives containing new polar substituents, such as phosphonate, phosphine oxide or pyridine N-oxide moieties, as replacements for the previoiusly reported quaternary ammonium moiety. Among these compounds, the 2-(α-hydroxybenzyl)pyridine N-oxide 5e exhibited moderate CCR5 antagonistic activity and had an acceptable pharmacokinetic profile in rats. Subsequent chemical modification was performed and compound (S)-5f possessing the (S)-configuration hydroxy group was found to be more active than the (R)-isomer. Replacement of the 1-benzoxepine ring with a 4-methylphenyl group by a 1-benzazepine ring with a 4-[2-(butoxy)ethoxy]phenyl group enhanced the activity in the binding assay. In addition, introduction of a 3-trifluoromethyl group on the phenyl group of the anilide moiety led to greatly increased activity in the HIV-1 envelope-mediated membrane fusion assay. In particular, compound (S)-5s showed the most potent CCR5 antagonistic activity (IC 50=7.2 nM) and inhibitory effect (IC50=5.4 nM) in the fusion assay, together with good pharmacokinetic properties in rats.

Nitroaryl phosphoramide compositions and methods for targeting and inhibiting undesirable cell growth or proliferation

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Page 17, (2010/02/09)

The present invention relates to nitroaryl-substituted phosphoramide prodrug compounds and methods of producing the same for use in targeting and inhibiting undesirable cell growth or proliferation.

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