- INHIBITORS OF HISTONE DEACETYLASE USEFUL FOR THE TREATMENT OR PREVENTION OF HIV INFECTION
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The present invention relates to Compounds of Formula (I): Formula (I) and pharmaceutically acceptable salts or prodrug thereof, wherein R1, R2, R3, Ra, Rb, A and B are as defined herein. The present invention also relates to compositions comprising at least one compound of Formula (I), and methods of using the compounds of Formula (I) for treating or preventing HIV infection in a subject.
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Page/Page column 183.1
(2020/02/23)
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- Synthesis, radiolabeling, and biological evaluation of (R)- and (S)-2-amino-5-[18F]fluoro-2-methylpentanoic acid ((R)-, (S)-[18F]FAMPe) as potential positron emission tomography tracers for brain tumors
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A novel 18F-labeled α,α-disubstituted amino acid-based tracer, 2-amino-5-[18F]fluoro-2-methylpentanoic acid ([18F]FAMPe), has been developed for brain tumor imaging with a longer alkyl side chain than previously reported c
- Bouhlel, Ahlem,Zhou, Dong,Li, Aixiao,Yuan, Liya,Rich, Keith M.,McConathy, Jonathan
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p. 3817 - 3829
(2015/05/27)
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- Stereoselective lodocyclization of (S)-allylalanine derivatives: γ-lactone vs cyclic carbamate formation
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An efficient procedure for highly chemo- and stereoselective cyclization of (S)-allylalanine derivatives is reported (diastereomeric ratios up to 96:4) where the reaction course can be completely controlled by switching from γ-lactones to cyclic carbamate
- Pattarozzi, Mariella,Zonta, Cristiano,Broxterman, Quirinus B.,Kaptein, Bernard,De Zorzi, Rita,Randaccio, Lucio,Scrimin, Paolo,Licini, Giulia
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p. 2365 - 2368
(2008/02/05)
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- Mag: A Cα-methylated, side-chain unsaturated α-amino acid. Introduction into model peptides and conformational preference
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By a chemo-enzymatic approach we synthesized the chiral, C(α)- methylated α-amino acid Mag, characterized by a side-chain C(γ)=C(δ) bond. We also prepared a series of model peptides containing Mag in combination with Aib and Ala. All of the peptides were fully characterized and their conformational preference was determined in solution by FT-IR absorption and 1H NMR investigations. X-Ray diffraction analyses of L-Mag, a derivative and three peptides are also presented. We find that this C(α)-methylated α- amino acid is an excellent β-turn and 310-helix former. A peptide with two Mag residues one on top of the other after one complete turn of the 310- helix has been synthesized and characterized. 2000 Elsevier Science Ltd.
- Peggion, Cristina,Flammengo, Roberto,Mossel, Eric,Broxterman, Quirinus B.,Kaptein, Bernard,Kamphuis, Johan,Formaggio, Fernando,Crisma, Marco,Toniolo, Claudio
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p. 3589 - 3601
(2007/10/03)
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