- Synthesis method of N-lauroyl amino acid salt
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The invention provides a synthesis method of N-lauroyl amino acid salt, which comprises the following steps: mixing amino acid, alkali and water according to a certain molar ratio to completely dissolve the amino acid, the alkali and the water, and carrying out reduced pressure distillation at 100-120 DEG C to remove water, so as to obtain amino acid salt; mixing amino acid salt and lauramide into a reaction container provided with a tail gas receiving device according to a certain proportion; stirring and reacting for a certain time at a certain temperature; after the reaction is finished, acidifying the reaction mixture by using a hydrochloric acid solution to precipitate the product, filtering and collecting the precipitate to obtain a purified product; carrying out forced air drying on the purified product to remove moisture, so as to obtain a dried product; and dissolving the product with ethanol, adding an alkali solution at a certain temperature, stirring to react for a period of time, cooling to crystallize, and carrying out suction filtration to obtain the lauroyl amino acid salt. Other substances are not used as solvents, so that the problems of over-high production and waste treatment cost and environmental pollution caused by the use of a large amount of solvents at present are solved, and the method has wide market prospects and social benefits.
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Paragraph 0032-0035
(2021/07/09)
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- Method used for synthesizing lauroyl amino acid sodium based on polyethylene glycol phase transfer catalyst
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The invention discloses a method used for synthesizing lauroyl amino acid sodium based on a polyethylene glycol phase transfer catalyst. The method comprises following steps: lauroyl amino acid sodium and solid sodium hydroxide are reacted in the presence of the polyethylene glycol phase transfer catalyst in ethanol medium so as to obtain a lauroyl amino acid sodium solution; the lauroyl amino acid sodium solution is subjected to cooling crystallization, filtering, and drying successively so as to obtain lauroyl amino acid sodium crystals. According to the method, solid sodium hydroxide is taken as the raw material so as to avoid introduction of water by sodium hydroxide solution in the prior art, product yield is higher; and at the same time, a problem that yellowing of products is easily caused because yellowing of sodium hydroxide is easily caused by contact with ethanol; adding of PEG-400 is capable of increasing solubility of sodium hydroxide in ethanol, and catalyst reaction is adopted, so that reaction efficiency is increased greatly; ethanol and PEG-400 are subjected to atmospheric distillation for recycling; the process route is simple; the method is friendly to the environment, and is capable of satisfying requirements of green chemical industry production.
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Paragraph 0034; 0035
(2017/03/14)
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- A laurel acyl amino acid synthetic method of sodium
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The invention relates to a synthetic method of lauric acyl amino acid sodium, particularly to a synthetic method which uses lauric acid and phosgene as raw materials. The synthetic method comprises the following steps: ensuring that the reaction lasts for 1 to 20 hours at a temperature of 60 to 100 DEG C with the effect of organic amide catalyst; obtaining acyl chloride through vacuum distillation after the reaction is finished; dripping lauric acyl chloride obtained according to the phosgene method into amino acids alkaline solution for reaction; controlling and ensuring the pH value to be within the range of 8 to 10, the reaction temperature to be 15 to 20 DEG C, and the reaction time to be 4 to 5 hours; carrying out cooling after the reaction is finished; acidizing the reaction solution to pH 1 to 2 with hydrochloric acid solution; filtering, washing and drying white sediment to obtain lauric acyl amino acid; dissolving the prepared lauric acyl amino acid with alcohol; adding alcohol solution with sodium hydroxide of equal molar amount; and crystallizing, sucking, filtering and drying after cooling to obtain the lauric acyl amino acid sodium. According to the invention, the synthetic method is reasonable in process, high in reaction efficiency and good in product quality; the three wastes are seldom generated; and no residual phosphorus and sulfur are contained in the product. Therefore, the synthetic method can be widely used in the production of high-end surface active agents, and has significant utility value and social and economic benefits.
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Paragraph 0025; 0027; 0028
(2016/10/09)
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- Method to Produce N-Acyl Amino Acid Surfactants Using N-Acyl Amino Acid Surfactants or the Corresponding Anhydrides as Catalysts
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A process of producing N-acyl amino acid based surfactants of Formula I, wherein, R is selected from C6 to C22 alkyl group, R1 is selected from H, C1 to C4 alkyl, R2 is selected from all groups on α carbon of natural amino acids, R3 is selected from COOX, CH2—SO3X, X is selected from Li+, Na+ or K+. The process comprising steps of: A) preparing fatty acid chlorides by halogenating fatty acids with either phosgene or thionyl chloride in the presence of catalytic amount of same or other N-acyl amino acid surfactant of Formula I or anhydrides of same surfactant; andB) reacting fatty acid chloride of step (A) with an amino acid in the presence of a base.
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- METHOD TO PRODUCE N-ACYL AMINO ACID SURFACTANTS USING N-ACYL AMINO ACID SURFACTANTS OR THE CORRESPONDING ANHYDRIDES AS CATALYSTS
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A process of producing N-acyl amino acid based surfactants of Formula (I), wherein, R is selected from C6 to C22 alkyl group, R1 is selected from H, C1 to C4 alkyl, R2 is selected from all groups on a carbon of natural amino acids, R3 is selected from COOX, CH2-SO3X, X is selected from Li+, Na+ or K+; said process comprising steps of A) preparing fatty acid chlorides by halogenating fatty acids with either phosgene or thionyl chloride in the presence of catalytic amount of same or other N-acyl amino acid surfactant of Formula (I) or anhydrides of same surfactant, Formula (II), wherein, R = C6 to C22 alkyl group, R1 = H, C1 to C4 alkyl, R2 = all groups on α carbon of natural amino acids, n = 0 to 4, X = C, SO and B) reacting fatty acid chloride of step (A) with an amino acid in the presence of a base under typical aqueous Schotten Baumann conditions such that said process does not employ a step of purification.
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