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137-16-6

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137-16-6 Usage

Uses

Different sources of media describe the Uses of 137-16-6 differently. You can refer to the following data:
1. Sodium lauroyl sarcosinate (INCI), also known as sarkosyl, is a white powder derived from sarcosine, which make it is fate-free and biodegradable. The surfactant is amphiphilic due to the hydrophobic 12-carbon chain (lauroyl) and the hydrophilic carboxylate. Sodium lauroyl sarcosinate is personal care products as well as in household and industrial applications, and it is used as a co-surfactant in cleanser formulations such as shampoos and body washes. It can also be used in oral care applications such as toothpastes and incorporated into syndet and combo bars. The typical usage levels range from 1-5% on an active basis.
2. Detergent, foaming agent, antienzyme for dentifrices: King, US 2689170 (1954 to Colgate-Palmolive).
3. N-Lauroylsarcosine is used for solubilization and separation of membrane proteins and glycoprotein's; reported to inhibit hexokinase. It is useful in concentrated salt solutions used in the cell lysis step during RNA purification (helps avoid excessive foaming). It has been used to indicate paramagnetic anisotropy sign change in micelle mesophage. Inhibits bacterial flora of human saliva/gut at 0.25% as well as acting as a fungi static agent in aqueous dispersion (1%).
4. Suitable forsolubilization and separation of membrane proteinslysis of cells during the isolation of RNA inhibition of hexokinase

Application

Sodium lauroyl sarcosinate (INCI) is mild, biodegradable anionic surfactants derived from sarcosine used as a foaming and cleansing agent in shampoo, shaving foam, toothpaste, and foam wash products. The surfactant is amphiphilic due to the hydrophobic 12-carbon chain (lauroyl) and the hydrophilic carboxylate. Sodium lauroyl sarcosinate is a high foam, eco-friendly surfactant. It has good chlorine stability with anti-corrosion properties. This surfactant has excellent ocular tolerance and gentleness. Sodium lauroyl sarcosinate is often seen in shampoos, bath, cleansing and shaving products as a foaming agent, surfactant, and hair conditioning agent. Sodium lauroyl sarcosinate has the ability to enhance the appearance and feel of hair by improving body, suppleness and sheen, especially in hair that is chemically damaged. This ingredient also serves to clean skin and hair by mixing with oil and dirt and enabling them to be rinsed away. As a modified fatty acid, it is thought to be more soluble, and have increased crystallinity and acidity compared to its original fatty acid composition.

Chemical Properties

white powder

General Description

N-Lauroylsarcosine is an anionic surfactant with an ability to denature proteins. Due to its microbicidal property, N-lauroylsarcosine is being considered as a potent anti-microbicide in topical formulations, especially against sexually transmitted diseases (STDs).

Flammability and Explosibility

Nonflammable

Biochem/physiol Actions

N-Lauroylsarcosine is an anionic surfactant which also has protein denaturant potency. In addition, it has been shown as a microbicide for sexually transmitted diseases.

Check Digit Verification of cas no

The CAS Registry Mumber 137-16-6 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 1,3 and 7 respectively; the second part has 2 digits, 1 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 137-16:
(5*1)+(4*3)+(3*7)+(2*1)+(1*6)=46
46 % 10 = 6
So 137-16-6 is a valid CAS Registry Number.

137-16-6 Well-known Company Product Price

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  • Sigma-Aldrich

  • (Y0001772)  Sodiumlauroylsarcosinate  EuropePharmacopoeia (EP) Reference Standard

  • 137-16-6

  • Y0001772

  • 1,880.19CNY

  • Detail
  • Aldrich

  • (61745)  N-Lauroylsarcosinesodiumsalt  ≥97.0% (HPLC)

  • 137-16-6

  • 61745-50G

  • 296.01CNY

  • Detail
  • Aldrich

  • (61745)  N-Lauroylsarcosinesodiumsalt  ≥97.0% (HPLC)

  • 137-16-6

  • 61745-250G

  • 888.03CNY

  • Detail
  • Aldrich

  • (61745)  N-Lauroylsarcosinesodiumsalt  ≥97.0% (HPLC)

  • 137-16-6

  • 61745-1KG

  • 2,197.26CNY

  • Detail

137-16-6SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 10, 2017

Revision Date: Aug 10, 2017

1.Identification

1.1 GHS Product identifier

Product name Sodium lauroylsarcosinate

1.2 Other means of identification

Product number -
Other names N-Dodecanoylsarcosine Sodium Salt

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:137-16-6 SDS

137-16-6Synthetic route

N-acyl sarcosinate
97-78-9

N-acyl sarcosinate

sodium N-lauroylsarcosinate
137-16-6

sodium N-lauroylsarcosinate

Conditions
ConditionsYield
With sodium hydroxide In ethanol at 50 - 70℃;99%
n-dodecanoyl chloride
112-16-3

n-dodecanoyl chloride

sarcosine
107-97-1

sarcosine

sodium N-lauroylsarcosinate
137-16-6

sodium N-lauroylsarcosinate

Conditions
ConditionsYield
With sodium hydroxide In water at 15 - 20℃; pH=8 - 10;97%
n-dodecanoyl chloride
112-16-3

n-dodecanoyl chloride

sodium sarcosinate
4316-73-8

sodium sarcosinate

sodium N-lauroylsarcosinate
137-16-6

sodium N-lauroylsarcosinate

Conditions
ConditionsYield
In water at 10 - 30℃; for 5h; pH=10.3 - 10.6; Schotten-Baumann Reaction; Inert atmosphere;
With sodium hydroxide In water at 10 - 30℃; for 5h; pH=10.3 - 10.6; Inert atmosphere;
lauric acid
143-07-7

lauric acid

sodium N-lauroylsarcosinate
137-16-6

sodium N-lauroylsarcosinate

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: sodium dodecanoylglycinate; thionyl chloride / 6 h / 25 °C / Inert atmosphere
2: water / 5 h / 10 - 30 °C / pH 10.3 - 10.6 / Inert atmosphere
View Scheme
Multi-step reaction with 2 steps
1: thionyl chloride; N-lauroyl glycenic lauric anhydride / 6 h / 25 °C / 760.05 Torr / Inert atmosphere
2: sodium hydroxide / water / 5 h / 10 - 30 °C / pH 10.3 - 10.6 / Inert atmosphere
View Scheme
2,2,2-trichloroethyl (2-(tert-butylcarbamoyl)phenyl)sulfamate

2,2,2-trichloroethyl (2-(tert-butylcarbamoyl)phenyl)sulfamate

sodium N-lauroylsarcosinate
137-16-6

sodium N-lauroylsarcosinate

N-(tert-butyl)-2-(2-(N-methyldodecanamido)acetamido)benzamide

N-(tert-butyl)-2-(2-(N-methyldodecanamido)acetamido)benzamide

Conditions
ConditionsYield
In chlorobenzene at 120℃; for 10h;72%

137-16-6Downstream Products

137-16-6Related news

Synergistic effects of chemical enhancers on skin permeability: A case study of Sodium lauroylsarcosinate (cas 137-16-6) and sorbitan monolaurate09/29/2019

Certain mixtures of chemicals are known to synergistically enhance skin permeability to drugs. Here, we report on the transport enhancing properties of mixtures of an anionic surfactant, sodium lauroylsarcosinate (NLS) and a non-ionic surfactant, sorbitan monolaurate (S20) in 1:1 phosphate buffe...detailed

137-16-6Relevant articles and documents

Synthesis method of N-lauroyl amino acid salt

-

Paragraph 0032-0035, (2021/07/09)

The invention provides a synthesis method of N-lauroyl amino acid salt, which comprises the following steps: mixing amino acid, alkali and water according to a certain molar ratio to completely dissolve the amino acid, the alkali and the water, and carrying out reduced pressure distillation at 100-120 DEG C to remove water, so as to obtain amino acid salt; mixing amino acid salt and lauramide into a reaction container provided with a tail gas receiving device according to a certain proportion; stirring and reacting for a certain time at a certain temperature; after the reaction is finished, acidifying the reaction mixture by using a hydrochloric acid solution to precipitate the product, filtering and collecting the precipitate to obtain a purified product; carrying out forced air drying on the purified product to remove moisture, so as to obtain a dried product; and dissolving the product with ethanol, adding an alkali solution at a certain temperature, stirring to react for a period of time, cooling to crystallize, and carrying out suction filtration to obtain the lauroyl amino acid salt. Other substances are not used as solvents, so that the problems of over-high production and waste treatment cost and environmental pollution caused by the use of a large amount of solvents at present are solved, and the method has wide market prospects and social benefits.

A laurel acyl amino acid synthetic method of sodium

-

Paragraph 0025; 0027; 0028, (2016/10/09)

The invention relates to a synthetic method of lauric acyl amino acid sodium, particularly to a synthetic method which uses lauric acid and phosgene as raw materials. The synthetic method comprises the following steps: ensuring that the reaction lasts for 1 to 20 hours at a temperature of 60 to 100 DEG C with the effect of organic amide catalyst; obtaining acyl chloride through vacuum distillation after the reaction is finished; dripping lauric acyl chloride obtained according to the phosgene method into amino acids alkaline solution for reaction; controlling and ensuring the pH value to be within the range of 8 to 10, the reaction temperature to be 15 to 20 DEG C, and the reaction time to be 4 to 5 hours; carrying out cooling after the reaction is finished; acidizing the reaction solution to pH 1 to 2 with hydrochloric acid solution; filtering, washing and drying white sediment to obtain lauric acyl amino acid; dissolving the prepared lauric acyl amino acid with alcohol; adding alcohol solution with sodium hydroxide of equal molar amount; and crystallizing, sucking, filtering and drying after cooling to obtain the lauric acyl amino acid sodium. According to the invention, the synthetic method is reasonable in process, high in reaction efficiency and good in product quality; the three wastes are seldom generated; and no residual phosphorus and sulfur are contained in the product. Therefore, the synthetic method can be widely used in the production of high-end surface active agents, and has significant utility value and social and economic benefits.

METHOD TO PRODUCE N-ACYL AMINO ACID SURFACTANTS USING N-ACYL AMINO ACID SURFACTANTS OR THE CORRESPONDING ANHYDRIDES AS CATALYSTS

-

, (2014/03/25)

A process of producing N-acyl amino acid based surfactants of Formula (I), wherein, R is selected from C6 to C22 alkyl group, R1 is selected from H, C1 to C4 alkyl, R2 is selected from all groups on a carbon of natural amino acids, R3 is selected from COOX, CH2-SO3X, X is selected from Li+, Na+ or K+; said process comprising steps of A) preparing fatty acid chlorides by halogenating fatty acids with either phosgene or thionyl chloride in the presence of catalytic amount of same or other N-acyl amino acid surfactant of Formula (I) or anhydrides of same surfactant, Formula (II), wherein, R = C6 to C22 alkyl group, R1 = H, C1 to C4 alkyl, R2 = all groups on α carbon of natural amino acids, n = 0 to 4, X = C, SO and B) reacting fatty acid chloride of step (A) with an amino acid in the presence of a base under typical aqueous Schotten Baumann conditions such that said process does not employ a step of purification.

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