- Multiturn Hollow Helices: Synthesis and Folding of Long Aromatic Oligoamides
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Aromatic oligoamides adopting helical conformations are synthesized by coupling carboxyl-terminated basic units having two, four, and eight residues to amine-terminated oligomer precursors. Coupling yields show no noticeable reduction with the size of the
- Ferrand, Yann,Gong, Bing,Huc, Ivan,Kauffmann, Brice,Liu, Rui,Lu, Zhong-Lin,Xu, Wenwu,Zeng, Xiao Cheng,Zhong, Yulong
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supporting information
p. 6938 - 6942
(2020/09/15)
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- Synthesis method of 5-amino-2, 4-dihydroxybenzoic acid
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The invention relates to a synthetic method of 5-amino-2, 4-dihydroxybenzoic acid, which comprises the following steps: with resorcinol as a raw material, carrying out Koble-Schmitt reaction to obtain2,4-dihydroxybenzoic acid; performing nitration reaction on 2,4-dihydroxybenzoic acid to obtain 5-nitro-2,4-dihydroxybenzoic acid; and carrying out reduction reaction on 5-nitro-2,4-dihydroxybenzoicacid to obtain a product 5-amino-2,4-dihydroxybenzoic acid. The method has the advantages of easy control of reaction process parameters, easily available raw materials, short reaction time, simple post-treatment, high atom utilization rate, high purity and high industrial feasibility.
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- Preparation method for 5-amino-2,4-dihydroxybenzoic acid
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The invention provides a preparation method for 5-amino-2,4-dihydroxybenzoic acid. The method comprises the steps that the raw material 2,4-dihydroxybenzoic acid is provided; the 2,4-dihydroxybenzoicacid is subjected to a nitration reaction to generate 5-
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Paragraph 0035; 0036; 0037; 0038; 0039; 0040; 0041-0043
(2019/04/26)
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- CAVITY-CONTAINING OLIGOMERS AND POLYMERS EFFECTIVE IN CRYOPRESERVATION
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The present invention provides compositions and methods for cryopreservation utilizing aromatic cavity-containing oligomers and polymers that contain structural motifs capable of shape-inducing intramolecular bonding to form cavities. The cavity-containin
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Paragraph 0033; 0116
(2019/06/09)
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- Diversity-oriented synthesis for novel, selective and drug-like inhibitors for a phosphatase from Mycobacterium tuberculosis
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Mycobacterium protein tyrosine phosphatase B (mPTPB) is a potential drug target of tuberculosis (TB). Using small molecule inhibitors of mPTPB could be a treatment to overcome emerging TB drug resistance. Using a Diversity-Oriented Synthesis (DOS) strateg
- He, Rongjun,Bai, Yunpeng,Yu, Zhi-Hong,Wu, Li,Gunawan, Andrea Michelle,Zhang, Zhong-Yin
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p. 1496 - 1499
(2014/12/10)
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- Nitration of some aromatic compounds by sodium nitrate in the presence of benzyltriphenylphosphonium peroxodisulfate
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A simple, mild, and regioselective method for the nitration of some aromatic compounds using sodium nitrate in the presence of benzyltriphenylphosphonium peroxodisulfate in acetonitrile as solvent is reported. Mild reaction conditions and good to excellent yields of the products are the noteworthy advantages of the method. Copyright Taylor & Francis Group, LLC.
- Tajik, Hassan,Zolfigol, Mohammad Ali,Albadi, Jalal,Eslami, Ramin
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p. 2771 - 2776
(2008/02/12)
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- ORGANIC COMPOUNDS
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Compounds of the formula are inhibitors of protein tyrosine phosphatases (PTPases) and, thus, may be employed for the treatment of conditions mediated by PTPase activity. The compounds of the present invention may also be employed as inhibitors of other enzymes characterized with a phosphotyrosine binding region such as the SH2 domain. Accordingly, the compounds of formula (I) may be employed for prevention and/or treatment of insulin resistance associated with obesity, glucose intolerance, diabetes mellitus, hypertension and ischemic diseases of the large and small blood vessels, conditions that accompany type-2 diabetes, including hyperlipidemia, hypertriglyceridemia, atherosclerosis, vascular restenosis, irritable bowel syndrome, pancreatitis, adipose cell tumors and carcinomas such as liposarcoma, dyslipidemia, and other disorders where insulin resistance is indicated. In addition, the compounds of the present invention may be employed to treat and/or prevent cancer (such as prostate or breast cancer), osteoporosis, neurodegenerative and infectious diseases, and diseases involving inflammation and the immune system.
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Page/Page column 105-106
(2010/11/27)
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- Synthesis of crescent aromatic oligoamides
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This article describes the synthetic procedures for the preparation of crescent (and helical) aromatic oligoamides developed in recent years in our laboratory. The large-scale preparation of a variety of monomers derived from various tetrasubstituted benzenes is presented. Three different strategies for constructing various oligomers consisting of meta- and meta/para-linked benzene residues are discussed. Factors affecting coupling efficiency and yields are analyzed. The developed synthetic methods have provided the basis for the preparation of longer oligomers and for the development of solid-phase synthesis.
- Yuan, Lihua,Sanford, Adam R.,Feng, Wen,Zhang, Aimin,Zhu, Jin,Zeng, Huaqiang,Yamato, Kazuhiro,Li, Minfeng,Ferguson, Joseph S.,Gong, Bing
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p. 10660 - 10669
(2007/10/03)
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- Decarboxylative Nitration of Some Simple Hydroxybenzoic Acids Using Cerium(IV) Ammonium Nitrate
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The mechanistic pathways proposed earlier in the Ce(IV) induced decarboxylation of aromatic acids have been examined in the light of new observations made.A simple, non-explosive, easy to control substitute to Bechman and Biermann's decarboxylative nitration is described and a plausible mechanism suggested.
- Chawla, H. Mohindra,Mittal, Ram S.
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p. 1129 - 1131
(2007/10/02)
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