An efficient entry to amino-substituted resorcylic acid derivatives for the synthesis of platensimycin and analogues
An efficient entry to protected amino-substituted resorcylic acid derivatives, methyl 3- or 5-amino-2,4-bis(methoxymethoxy)benzoate, is reported. Both derivatives can be used for the synthesis of platensimycin and its analogues. Georg Thieme Verlag Stuttg
IMMUNOMODULATORS, COMPOSITIONS AND METHODS THERE OF
Provided herein is compounds of Formula I, methods of using the compounds as immunomodulators, and pharmaceutical compositions comprising such compounds. The compounds are useful in treating, preventing or ameliorating diseases or disorders such as cancer
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Page/Page column 29
(2020/05/06)
IMMUNOMODULATORS, COMPOSITIONS AND METHODS THEREOF
Provided herein are compounds of Formula (I), methods of using the compounds as immunomodulators, and pharmaceutical compositions comprising such compounds. The compounds are useful in treating, preventing or ameliorating diseases or disorders such as cancer or infections.
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Page/Page column 42-43
(2020/08/22)
Multiturn Hollow Helices: Synthesis and Folding of Long Aromatic Oligoamides
Aromatic oligoamides adopting helical conformations are synthesized by coupling carboxyl-terminated basic units having two, four, and eight residues to amine-terminated oligomer precursors. Coupling yields show no noticeable reduction with the size of the
CAVITY-CONTAINING OLIGOMERS AND POLYMERS EFFECTIVE IN CRYOPRESERVATION
The present invention provides compositions and methods for cryopreservation utilizing aromatic cavity-containing oligomers and polymers that contain structural motifs capable of shape-inducing intramolecular bonding to form cavities. The cavity-containin
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Paragraph 0033; 0116
(2019/06/09)
HETEROCYCLIC COMPOUNDS AS IMMUNOMODULATORS
Disclosed are compounds of Formula (I), methods of using the compounds as immunomodulators, and pharmaceutical compositions comprising such compounds. The compounds are useful in treating, preventing or ameliorating diseases or disorders such as cancer or
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Page/Page column 87-88
(2017/06/12)
Synthesis of crescent aromatic oligoamides
This article describes the synthetic procedures for the preparation of crescent (and helical) aromatic oligoamides developed in recent years in our laboratory. The large-scale preparation of a variety of monomers derived from various tetrasubstituted benzenes is presented. Three different strategies for constructing various oligomers consisting of meta- and meta/para-linked benzene residues are discussed. Factors affecting coupling efficiency and yields are analyzed. The developed synthetic methods have provided the basis for the preparation of longer oligomers and for the development of solid-phase synthesis.
Yuan, Lihua,Sanford, Adam R.,Feng, Wen,Zhang, Aimin,Zhu, Jin,Zeng, Huaqiang,Yamato, Kazuhiro,Li, Minfeng,Ferguson, Joseph S.,Gong, Bing
p. 10660 - 10669
(2007/10/03)
A new class of folding oligomers: Crescent oligoamides [4]