137307-61-0

Basic information

• Product Name: N-BENZYLPHENYLGLYCINE METHYL ESTER
• Synonyms: N-BENZYLPHENYLGLYCINE METHYL ESTER;Glycine, N-phenyl-N-(phenylmethyl)-, methylester;Methyl 2-(benzyl(phenyl)aMino)acetate
• CAS NO: 137307-61-0
• Molecular Formula: C₁₆H₁₇NO₂
• Molecular Weight: 255.31168
• Mol File: 137307-61-0.mol

Chemical Properties

• Boiling Point: 387.9±35.0 °C(Predicted)
• Appearance: /
• Density: 1.136±0.06 g/cm3(Predicted)
• PKA: 2.46±0.50(Predicted)
• CAS DataBase Reference: N-BENZYLPHENYLGLYCINE METHYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: N-BENZYLPHENYLGLYCINE METHYL ESTER(137307-61-0)
• EPA Substance Registry System: N-BENZYLPHENYLGLYCINE METHYL ESTER(137307-61-0)

Safety Data

• Hazardous Substances Data: 137307-61-0(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
N-Benzylphenylglycine methyl ester is used as a key intermediate in the synthesis of pharmaceutical drugs for its potential therapeutic properties.
Used in Anti-Inflammatory Applications:
As an anti-inflammatory agent, N-Benzylphenylglycine methyl ester is being studied for its potential to alleviate inflammation, which could have significant implications for the treatment of various inflammatory conditions.
Used in Drug Development:
In the development of new drugs, N-Benzylphenylglycine methyl ester is utilized for its potential to contribute to the creation of novel therapeutic agents, enhancing the range of treatments available for different medical conditions.

Upstream product

• 186581-53-3 diazomethane 
• 23582-63-0 N-Benzyl-(S)-phenyl glycine 
• 16695-14-0 Malonic acid monomethyl ester 
• 758640-21-0 N-Benzylaniline 
• 108-59-8 malonic acid dimethyl ester 
• 100-46-9 benzylamine 
• 100-52-7 benzaldehyde 
• 96-32-2 bromoacetic acid methyl ester 
• 538-51-2 benzylidene phenylamine 
• 62-53-3 aniline 

Relevant articles and documents

Transition-metal-free decarboxylation of dimethyl malonate: An efficient construction of α-amino acid esters using TBAI/TBHP

A transition-metal-free decarboxylation coupling process for the preparation of α-amino acid esters, which succeeded in merging hydrolysis/decarboxylation/nucleophilic substitution, is well described. This strategy uses commercially available inexpensive starting materials, catalysts and oxidants and has a wide substrate scope and operational simplicity. This journal is

Aza-Wittig Rearrangements of N-Benzyl and N-Allyl Glycine Methyl Esters. Discovery of a Surprising Cascade Aza-Wittig Rearrangement/Hydroboration Reaction

Treatment of N-(arylmethyl)-N-aryl or N-allyl-N-aryl glycine methyl ester derivatives with nBu2BOTf and iPr2NEt effects an aza-Wittig rearrangement that provides N-aryl phenylalanine methyl ester derivatives and N-aryl allylglycine methyl ester derivatives, respectively, in good yield with moderate to good diastereoselectivity. Under similar conditions, analogous substrates bearing N-carbonyl groups are converted to 1,4,2-oxazaborole derivatives. Additionally, N-allyl-N-aryl glycine methyl ester derivatives subjected to similar conditions at elevated temperatures undergo an aza-[2,3]-Wittig rearrangement, followed by a subsequent hydroboration oxidation reaction, to afford substituted amino alcohol products.

Aza-[1,2]-Wittig rearrangements of N-benzyl glycine methyl esters. A new approach to the synthesis of N-aryl phenylalanine derivatives

Treatment of N-(arylmethyl)-N-aryl glycine methyl ester derivatives with Bu2BOTf and iPr2NEt effects an aza-[1,2]-Wittig rearrangement that provides N-aryl phenylalanine methyl esters in good yields. Analogous substrates bearing N-carbonyl groups are converted to 1,4,2-oxazaborole derivatives under similar conditions.

A new strategy for the construction of α-amino acid esters via decarboxylation

A new α-amino acid esters formation reaction has been developed via decarboxylation. The methodology is distinguished by its practical novelty in terms of the readily accessible starting materials, environmentally benign reaction conditions and waste streams, and wide substrate scope.