1375301-90-8

Basic information

• Product Name: 1,7-Naphthyridin-8(7H)-one, 3-bromo-
• Synonyms: 1,7-Naphthyridin-8(7H)-one, 3-bromo-;3-Bromo-1,7-naphthyridin-8(7H)-one
• CAS NO: 1375301-90-8
• Molecular Formula: C8H5BrN2O
• Molecular Weight: 225.0421
• EINECS: -0
• Mol File: 1375301-90-8.mol

Chemical Properties

• Boiling Point: 468.9±45.0 °C(Predicted)
• Appearance: /
• Density: 1.711±0.06 g/cm3(Predicted)
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 10.80±0.20(Predicted)
• CAS DataBase Reference: 1,7-Naphthyridin-8(7H)-one, 3-bromo-(CAS DataBase Reference)
• NIST Chemistry Reference: 1,7-Naphthyridin-8(7H)-one, 3-bromo-(1375301-90-8)
• EPA Substance Registry System: 1,7-Naphthyridin-8(7H)-one, 3-bromo-(1375301-90-8)

Safety Data

• Hazardous Substances Data: 1375301-90-8(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
1,7-Naphthyridin-8(7H)-one, 3-bromois used as a building block for the development of pharmaceuticals, contributing to the creation of new drugs for the treatment of various diseases.
Used in Agrochemical Industry:
1,7-Naphthyridin-8(7H)-one, 3-bromois used as a building block for the development of agrochemicals, aiding in the production of compounds for agricultural applications.
Used in Drug Discovery:
1,7-Naphthyridin-8(7H)-one, 3-bromois used as a research tool in drug discovery, helping researchers identify and develop new therapeutic agents.
Used in Chemical Biology:
1,7-Naphthyridin-8(7H)-one, 3-bromois used as a research tool in chemical biology, enabling the study of biological processes and the development of compounds with potential biological activity.

Upstream product

• 156072-86-5 5-bromo-3-methylpyridine-2-carbonitrile 
• 1429870-16-5 5-bromo-3-methyl-pyridine-2-carboxylic acid 1-dimethylamino-meth-(E)-ylideneamide 
• 1400645-41-1 5-bromo-3-methyl-pyridine-2-carboxylic acid amide 
• 794592-13-5 5-bromo-3-methyl-pyridine-2-carboxylic acid ethyl ester 

Downstream Products

• 1429869-84-0 8-[3-((R)-5-amino-3-difluoromethyl-3,6-dihydro-2H-[1,4]oxazin-3-yl)-4-fluoro-phenylamino]-[1,7]naphthyridine-3-carbonitrile 
• 1260670-05-0 3-bromo-8-chloro-[1,7]naphthyridine 
• 1429869-83-9 [3-((R)-5-amino-3-difluoromethyl-3,6-dihydro-2H-[1,4]oxazin-3-yl)-4-fluoro-phenyl]-(3-bromo-[1,7]naphthyridin-8-yl)-amine 
• 1600511-75-8 8-chloro-3-methoxy-1,7-naphthyridine 
• 1569695-13-1 C₉H₈N₂O₂ 

Relevant articles and documents

C5-C6-CARBOCYCLIC FUSED IMINOTHIADIAZINE DIOXIDES AS BACE INHIBITORS, COMPOSITIONS, AND THEIR USE

In its many embodiments, the present invention provides certain C5-C6-carbocyclic fused iminothiazine dioxide compounds, including compounds Formula (I): and tautomers thereof, and pharmaceutically acceptable salts of said compounds and said tautomers, wherein R1, ring A, RA, m, -L1-, ring B, RB, n, q, ring C, RC, and p are as defined herein. The novel compounds of the invention are useful as BACE inhibitors and/or for the treatment and prevention of various pathologies related thereto. Pharmaceutical compositions comprising one or more such compounds (alone and in combination with one or more other active agents), and methods for their preparation and use, including for the possible treatment of Alzheimer's disease, are also disclosed.

S-IMINO-S-OXO IMINOTHIAZINE COMPOUNDS AS BACE INHIBITORS, COMPOSITIONS, AND THEIR USE

In its many embodiments, the present invention provides certain C-6 spirocarbocyclic iminothiadiazine compounds, including compounds Formula (I): or a tautomer thereof, and pharmaceutically acceptable salts of said compounds and said tautomers, wherein R1A, R1B, R2A, R2B, R2, R3, RN, ring A, RA, m, ring B, RB, and n are as defined herein. The novel compounds of the invention are useful as BACE inhibitors and/or for the treatment and prevention of various pathologies related thereto. Pharmaceutical compositions comprising one or more such compounds (alone and in combination with one or more other active agents), and methods for their preparation and use, including for the possible treatment of Alzheimer's disease, are also disclosed.

NOVEL OXAZINE DERIVATIVES AND THEIR USE IN THE TREATMENT OF DISEASE

The invention relates to novel oxazine derivatives of formula (I), and pharmaceutically acceptable salts thereof, in which all of the variables are as defined in the specification, pharmaceutical compositions thereof, combinations thereof, and their use as medicaments, particularly for the treatment of Alzheimer's Disease or diabetes via inhibition of BACE-1 or BACE-2.