137803-61-3

Basic information

• Product Name: ({(1R,2S)-2-[(3,5-di-tert-butyl-4-hydroxyphenyl)sulfanyl]-1-methylpropyl}oxy)acetic acid
• CAS NO: 137803-61-3
• Molecular Formula: C₂₀H₃₂O₄S
• Molecular Weight: 368.5307
• Mol File: 137803-61-3.mol

Chemical Properties

• Boiling Point: 476.2°C at 760 mmHg
• Flash Point: 241.8°C
• Density: 1.11g/cm³
• Vapor Pressure: 7.08E-10mmHg at 25°C
• Refractive Index: 1.542
• CAS DataBase Reference: ({(1R,2S)-2-[(3,5-di-tert-butyl-4-hydroxyphenyl)sulfanyl]-1-methylpropyl}oxy)acetic acid(CAS DataBase Reference)
• NIST Chemistry Reference: ({(1R,2S)-2-[(3,5-di-tert-butyl-4-hydroxyphenyl)sulfanyl]-1-methylpropyl}oxy)acetic acid(137803-61-3)
• EPA Substance Registry System: ({(1R,2S)-2-[(3,5-di-tert-butyl-4-hydroxyphenyl)sulfanyl]-1-methylpropyl}oxy)acetic acid(137803-61-3)

Safety Data

• Hazardous Substances Data: 137803-61-3(Hazardous Substances Data)

Upstream product

• 138752-87-1 (+/-)2,6-bis(1,1-dimethylethyl)-4-[(2S*-hydroxy-1R*-methylpropyl)-thio]phenol 
• 5292-43-3 bromoacetic acid tert-butyl ester 
• 3926-62-3 sodium monochloroacetic acid 

Relevant articles and documents

Phenolic thioetheramides

The present invention relates to phenolic thioetheramides of the formula STR1 wherein R1 and R2 are tert-alkyl or phenyl, Alk1 and Alk2 are alkylene; X is sulfur or oxygen, m is 0, 1, or 2; and R is STR2 wherein R3 and R4 are hydrogen or alkyl and Alk3 is alkylene.

2-AMINOETHANESULFONIC ACID DERIVATIVES OF 3,5-DISUBSTITUTED-4-HYDROXY-PHENOLIC THIOETHERS

The present invention relates to compounds of the Formula I:wherein R1 and R2 are the same or different and independently represent tert-alkyl, halogen, or phenyl; Alk 1 represents straight or branched chain alkylene of 2 to 10 carbon atoms which can optionally be substituted by hydroxy, provided that said hydroxy is not attached to a carbon which is adjacent to sulfur or oxygen, X represents sulfur or oxygen, and Alk 2 represents straight or branched chain alkylene of 1 to 4 carbon atoms; and the pharmaceutically acceptable salts thereof. These compounds are specific 5-lipoxygenase inhibitors and are useful as anti-inflammatory and anti-allergy agents and in the treatment of conditions mediated by 5-lipoxygenase

Process and preparation of α-alkoxy acetic acids and their salts

A process for producing an α-alkoxy acetic acids and salts thereof which comprises reacting an alcohol of the formula STR1 wherein R1, R2 and R3 can be hydrogen, alkyl, alkoxy, halo, phenyl, substituted phenyl, or hydroxy;

Process for preparation of α-alkoxy acetic acids and their salts

A process for producing an α-alkoxy acetic acids and salts thereof which comprises reacting an alcohol of the formula R--OH wherein R is alkyl, substituted alkyl, or cycloalkyl, or cycloalkyl alkyl with a base in an aprotic organic solvent to give an alko

Novel phenolic thioethers as inhibitors of 5-lipoxygenase

The compounds of the present invention comprise substituted phenolic thioethers represented by the formula: STR1 wherein: R1 and R2 are the same or different and independently represent tert-alkyl or phenyl; A represents methylene or methylene substituted by alkyl, dialkyl or hydroxy, provided that when A includes hydroxymethylene, the hydroxymethylene group is not adjacent to a heteroatom; B represents sulfur, sulfoxide, sulfone, oxygen, --NH-- or nitrogen substituted by alkyl, phenyl, benzyl, substituted phenyl or substituted benzyl; C represents methylene or methylene substituted by alkyl; R3 represents CO2 H, CO2 -alkyl or a tetrazole group; m is 0 or 1, n is 2, 3 or 4 and p is 1, 2 or 3; and the pharmaceutically acceptable salts thereof. The compounds of the present invention are specific inhibitors of 5-lipoxygenase and, therefore, are useful in the treatment of local and systemic inflammation, allergy and hypersensitivity reactions and other disorders in which agents formed in the 5-lipoxygenase metabolic pathway are involved.