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Pomolic Acid, a pentacyclic triterpene derived from Euscaphis japonica, is an inhibitor of CXCR4. It is known for its anti-cancer and anti-viral properties, making it a potential therapeutic agent for various medical applications.

13849-91-7

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13849-91-7 Usage

Uses

Used in Anticancer Applications:
POMOLIC ACID is used as an anticancer agent for its ability to inhibit cancer metastasis. It targets MCF7 human breast cancer cells, demonstrating potential in the treatment of cancer metastasis.
Used in Antiviral Applications:
POMOLIC ACID is used as an anti-viral agent for its effectiveness against HIV, showcasing its potential in combating viral infections.

Check Digit Verification of cas no

The CAS Registry Mumber 13849-91-7 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,3,8,4 and 9 respectively; the second part has 2 digits, 9 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 13849-91:
(7*1)+(6*3)+(5*8)+(4*4)+(3*9)+(2*9)+(1*1)=127
127 % 10 = 7
So 13849-91-7 is a valid CAS Registry Number.
InChI:InChI=1/C30H48O4/c1-18-10-15-30(24(32)33)17-16-27(5)19(23(30)29(18,7)34)8-9-21-26(4)13-12-22(31)25(2,3)20(26)11-14-28(21,27)6/h8,18,20-23,31,34H,9-17H2,1-7H3,(H,32,33)/t18-,20?,21-,22+,23+,26+,27-,28-,29-,30+/m1/s1

13849-91-7Relevant articles and documents

En route to anti-glioblastoma active pomolic acid

Kraft, Oliver,Wiemann, Jana,Al-Harrasi, Ahmed,Csuk, René

, p. 29 - 32 (2019/05/06)

Tormentic acid (3) can be easily photo-reduced by Saito's procedure and is an ideal starting material for the straightforward synthesis of pomolic acid (1).

A remarkably simple and convergent partial synthesis of pomolic acid

Wiemann, Jana,Deckelmann, Anne M.,Csuk, René

, p. 3952 - 3953 (2016/08/09)

Mixtures of tormentic and euscaphic acid can be used to access pomolic acid using a convergent synthetic approach. This approach constitutes at present the best and shortest route to pomolic acid.

Triterpenoid saponins from Ilex mamillata C.Y. Wu ex C.J. Tseng

Che, Yan-Yun,Tu, Peng-Fei,Zhang, Liang,Li, Ning,Zeng, Ke-Wu

, p. 1991 - 1995,5 (2020/09/09)

Two new triterpenoid saponins, ilemaminosides A and B (1 and 2) along with six known saponins (3-8) were isolated from 70% ethanolic extract of the leaves of Ilex mamillata C.Y. Wu ex C.J. Tseng. The new saponins were characterised as 3-O -α- L-arabinopyranosyl-ilexgenin B (1) and 3-O-β-D- glucopyranosyl-(1→3) -α-L-arabinopyranosyl-ilexgenin B (2). The structures of compounds 1 and 2 were elucidated on the basis of the chemical and spectroscopic methods, and the structures of known compounds were identified by comparison of their spectroscopic data with those reported in the literature. The compounds showed inhibitory activities in anti-inflammatory assay invitro with IC50 values in the range 25.37-38.33gmL1.

New Biologically Active Triterpenoid Saponins from Scabiosa tschiliensis

Zheng, Quan,Koike, Kazuo,Han, Li-Kun,Okuda, Hiromichi,Nikaido, Tamotsu

, p. 604 - 613 (2007/10/03)

Eleven new triterpenoid saponins, scabiosaponins A-K (1-11), and hookerosides A (12) and B (13) were isolated from the whole plants of Scabiosa tschiliensis. The structures of the new compounds were established on the basis of extensive NMR (DEPT, DQF-COSY, HETCOR, TOCSY, HMQC, HMQC-TOCSY, HMBC, and NOESY) and MS studies coupled with chemical degradations. The biological activity of compounds 1-10, 12, and 13 and prosapogenin 1b were examined against pancreatic lipase. Scabiosaponins E, F, G, I (5, 6, 7, 9), hookerosides A, B (12, 13), and prosapogenin 1b all exhibited strong inhibition of pancreatic lipase in vitro.

Triterpenoid saponins from Ilex latifolia

Ouyang, Ming-An,Liu, Yu-Qing,Wang, Han-Qing,Yang, Chong-Ren

, p. 2483 - 2486 (2007/10/03)

Three new triterpenoid saponins, latifolosides F, G, H were isolated from the leaves of Ilex latifolia. Their structures were elucidated on the basis of chemical and spectral evidence. Latifoloside F was determined to be 3-O-[α-L-rhamnopyranosyl(1-2)]-[β-D-glucopyranosyl(1-3)-]-α-L- arabinopyranosyl ilexgenin B 28-O-[α-L-rhamnopyranosyl(1-2)]-β-D- glucopyranoside. Latifoloside G was 3-O-[α-L-rhamnopyranosyl(1-2)]-[β-D- glucopyranosyl(1-3)-]-α-L-arabinopyranosyl pomolic acid 28-O-[α-L- rhamnopyranosyl(1-2)]-β-D-glucopyranoside. Latifolioside H(3) was 3-O-[α- L-rhamnopyranosyl(1-2)]-[β-D-glucopyranosyl(1-3)-]-α-L-arabinopyranosyl siaresinolic acid 28-O-[α-L-rhamnopyranosyl(1-2)]-β-D-glucopyranoside.

Triterpenoid saponins from the leaves of Ilex latifolia

Ouyang, Ming-An,Wang, Han-Qing,Liu, Yu-Qing,Yang, Chong-Ren

, p. 1501 - 1505 (2007/10/03)

Five new triterpenoid saponins latifolosides A-E were isolated from the leaves of Ilex latifolia, along with a known compound. Their chemical structures have been elucidated on the basis of the chemical and spectral methods.

Triterpenoid saponins of aquifoliaceous plants. VIII. Ilexosides XXIX-XXXII from the leaves of Ilex rotunda THUNB.

Amimoto,Yoshikawa,Arihara

, p. 3138 - 3141 (2007/10/02)

From the fresh leaves of Ilex rotunda, were isolated four new saponins named ilexosides XXIX-XXXII, together with the known saponins pedunculoside, ziyu-glycoside I, suavissimoside F1 and chikusetsusaponin IVa. Their structures were established on the basis of spectral and chemical evidence.

TRITERPENE SAPONINS FROM FRUIT OF ILEX CRENATA

Kakuno, Takashi,Yoshikawa, Kazuko,Arihara, Shigenobu

, p. 2809 - 2812 (2007/10/02)

From the fresh fruits of Ilex crenata have been isolated six new saponins named ilexosides III-VIII, respectively, along with the known saponin, ilexoside II.Their structures were established on the basis of spectral and chemical evidence. Key words: Ilex crenata; Aquifoliaceae; pentacyclic triterpene; ilexoside; pomolic acid; bisdesmoside.

TRITERPENES FROM ILEX ROTUNDA FRUITS

Nakatani, Munehiro,Miyazaki, Yuji,Iwashita, Takashi,Naoki, Hideo,Hase, Tsunao

, p. 1479 - 1482 (2007/10/02)

Two new triterpenes have been isolated from the fruits of Ilex rotunda along with three known triterpenoids ulsolic acid, rotundic acid and peduncloside.Their structures were characterized as 3β,19α,24-trihydroxyurs-12-ene-28-oic acid and 3β,19α-dihydroxyurs-12-ene-23,28-dioic acid by spectral and chemical means. - Keywords: Ilex rotunda; Aquifoliaceae; pentacyclic triterpene; rotungenic acid; ulsolic acid; rotundic acid; peduncloside.

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