1387445-50-2

Basic information

• Product Name: N-Boc-5-Methoxy-7-Methylindole, 97%
• Synonyms: N-Boc-5-Methoxy-7-Methylindole, 97%;tert-butyl 5-methoxy-7-methyl-1H-indole-1-carboxylate;EOS-60928
• CAS NO: 1387445-50-2
• Molecular Formula: C15H19NO3
• Molecular Weight: 261.31626
• Mol File: 1387445-50-2.mol

Chemical Properties

• Appearance: /Solid
• Storage Temp.: 2-8°C
• CAS DataBase Reference: N-Boc-5-Methoxy-7-Methylindole, 97%(CAS DataBase Reference)
• NIST Chemistry Reference: N-Boc-5-Methoxy-7-Methylindole, 97%(1387445-50-2)
• EPA Substance Registry System: N-Boc-5-Methoxy-7-Methylindole, 97%(1387445-50-2)

Safety Data

• Hazardous Substances Data: 1387445-50-2(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Synthesis:
N-Boc-5-Methoxy-7-Methylindole, 97% is used as a building block for the synthesis of various pharmaceuticals due to its versatile reactivity and structural properties. The Boc-protecting group provides increased stability and allows for selective modification of the compound, ensuring consistent and reliable results in chemical reactions.
Used in Organic Compound Synthesis:
In the field of organic chemistry, N-Boc-5-Methoxy-7-Methylindole, 97% is utilized as a key component in the production of complex chemical structures. Its high purity and reactivity make it a sought-after compound for creating new organic compounds with specific properties and applications.
Used in Research and Development:
N-Boc-5-Methoxy-7-Methylindole, 97% is also employed in research and development for the exploration of new chemical reactions, synthesis methods, and potential applications in various industries. Its unique properties and high purity contribute to the advancement of scientific knowledge and the discovery of innovative solutions.

Upstream product

• 61019-05-4 5-methoxy-7-methyl-1H-indole 
• 24424-99-5 di-tert-butyl dicarbonate 

Relevant articles and documents

Discovery of 4-((2 S,4 S)-4-Ethoxy-1-((5-methoxy-7-methyl-1 H-indol-4-yl)methyl)piperidin-2-yl)benzoic Acid (LNP023), a Factor B Inhibitor Specifically Designed to Be Applicable to Treating a Diverse Array of Complement Mediated Diseases

The alternative pathway (AP) of the complement system is a key contributor to the pathogenesis of several human diseases including age-related macular degeneration, paroxysmal nocturnal hemoglobinuria (PNH), atypical hemolytic uremic syndrome (aHUS), and various glomerular diseases. The serine protease factor B (FB) is a key node in the AP and is integral to the formation of C3 and C5 convertase. Despite the prominent role of FB in the AP, selective orally bioavailable inhibitors, beyond our own efforts, have not been reported previously. Herein we describe in more detail our efforts to identify FB inhibitors by high-throughput screening (HTS) and leveraging insights from several X-ray cocrystal structures during optimization efforts. This work culminated in the discovery of LNP023 (41), which is currently being evaluated clinically in several diverse AP mediated indications.

PIPERIDINYL INDOLE DERIVATIVES AND THEIR USE AS COMPLEMENT FACTOR B INHIBITORS

The present invention provides a compound of formula I: (I) a method for manufacturing the compounds of the invention, and its therapeutic uses as inhibitors of the complement alternative pathway, in particular of Factor B. The present invention further p