61019-05-4

Usage

Uses

Used in Chemical Research:
5-Methoxy-7-methylindole is used as a chemical intermediate for the synthesis of various organic compounds. Its unique structure allows it to be a versatile building block in the development of new chemical entities, enabling researchers to explore its potential applications in various fields.
Used in Pharmaceutical Industry:
5-Methoxy-7-methylindole is used as a pharmaceutical intermediate for the development of new drugs. Its presence in the molecular structure of certain compounds can impart specific biological activities, making it a valuable component in the design and synthesis of novel therapeutic agents. This intermediate plays a crucial role in the advancement of pharmaceutical research and the discovery of new medications to treat various diseases and medical conditions.

Upstream product

• 74798-63-3 1-(2-amino-5-methoxy-3-methylphenyl)-2-chloroethanone 
• 102-50-1 2-methyl-4-methoxyaniline 

Downstream Products

• 1387445-50-2 tert-butyl 5-methoxy-7-methyl-1H-indole-1-carboxylate 

Relevant academic research and scientific papers

An indole derivative and its application

The present invention relates to an indole derivative shown in formula (I-1) and its use in the preparation of a drug for the prevention and / or treatment of indications associated with the S1P receptor disorders. Indole derivatives of the present invent

Preparation method of 7-methyl indole

The invention relates to a preparation method of 7-methyl indole. The preparation method comprises the following steps: (1) adding an organic solvent into a reaction kettle, heating, carrying out atmospheric distillation, adding a compound represented by formula (I), pyrrole and DMFDMA, carrying out reflux reaction, cooling, adding water and toluene into the reaction system, extracting, recoveringthe organic phase, drying with sodium sulfate, carrying out reduced pressure distillation to remove toluene, and drying to obtain an intermediate; and (2) adding the intermediate obtained in the step(1), an organic solvent and 5% Pd/C into a reaction kettle, carrying out normal-pressure hydrogenation and reflux reaction, carrying out diatomite suction filtration to remove Pd/C, carrying out vacuum concentration to obtain a brownish black oily liquid, adding water and ethyl acetate to extract a water phase, recovering an organic layer, washing with brine, drying with sodium sulfate, concentrating to dryness, and passing through a silica gel column to obtain white solid 7-methyl indole. The preparation method is simple, high in repeatability, stable in yield and suitable for large-scale production.

Studies on Several 7-Substituted N,N-Dimethyltryptamines

Several 7-substituted derivatives of N,N-dimethyltryptamine (DMT) were prepared and evaluated in the rat fundus serotonin receptor assay and in a behavioral (discriminative stimulus) assay in rats.Both 7-Me- and 5-Ome-7-Me-DMT possess a higher pA2, and 5,7-(OMe)2-DMT a lower pA2, than that of DMT itself.Like DMT, all three of these compounds produce behavioral effects in rats which are similar to those of the hallucinogen 5-OMe-DMT.Although 7-Et- and 7-Br-DMT possess a higher serotonin receptor affinity than DMT, neither produce behavioral effects which parallelthose of 5-OMe-DMT.In contrast, 6-OMe-DMT and its 5-OMe derivative do not interact with the serotonin receptors in a competitive manner and are inactive in the discriminative stimulus assay.