N-Boc-5-Methoxy-7-Methylindole, 97%

Base Information

• Chemical Name: N-Boc-5-Methoxy-7-Methylindole, 97%
• CAS No.: 1387445-50-2
• Molecular Formula: C₁₅H₁₉NO₃
• Molecular Weight: 261.321
• Mol file: 1387445-50-2.mol

Synonyms:N-Boc-5-Methoxy-7-Methylindole, 97%;tert-butyl 5-methoxy-7-methyl-1H-indole-1-carboxylate

Chemical Property of N-Boc-5-Methoxy-7-Methylindole, 97%

Chemical Property:

• PSA: 40.46000
• LogP: 3.74150
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

tert-Butyl5-methoxy-7-methyl-1H-indole-1-carboxylate 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-Boc-5-Methoxy-7-Methylindole, 97%

There total 1 articles about N-Boc-5-Methoxy-7-Methylindole, 97% which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

5-methoxy-7-methyl-1H-indole (61019-05-4) + di-tert-butyl dicarbonate (24424-99-5) → tert-butyl 5-methoxy-7-methyl-1H-indole-1-carboxylate (1387445-50-2)

Guidance literature:

With dmap; triethylamine; In tetrahydrofuran; at 50 ℃; for 5h;

DOI:10.1021/acs.jmedchem.9b01870

Reference yield:

tert-butyl 5-methoxy-7-methyl-1H-indole-1-carboxylate (1387445-50-2) → (-)-4-((2S,4S)-4-methoxy-1-((5-methoxy-7-methyl-1H-indol-4-yl)methyl)piperidin-2-yl)benzoic acid

Guidance literature:

Multi-step reaction with 2 steps

1.1: oxalyl dichloride / dichloromethane / 16.5 h / 20 °C / Inert atmosphere

1.2: 2.25 h / -14 °C

2.1: sodium tris(acetoxy)borohydride / trans-1,2-dichloroethylene / 72 h / 20 °C / Inert atmosphere

2.2: 22 h / 70 °C

With oxalyl dichloride; sodium tris(acetoxy)borohydride; In trans-1,2-dichloroethylene; dichloromethane;

Reference yield:

tert-butyl 5-methoxy-7-methyl-1H-indole-1-carboxylate (1387445-50-2) → (±)-tert-butyl 5-methoxy-4-(rel-(2S,4S)-(4-methoxy-2-(4-(methoxycarbonyl)phenyl)piperidin-1-yl)methyl)-7-methyl-1H-indole-1-carboxylate

Guidance literature:

Multi-step reaction with 2 steps

1.1: oxalyl dichloride / dichloromethane / 16.5 h / 20 °C / Inert atmosphere

1.2: 2.25 h / -14 °C

2.1: sodium tris(acetoxy)borohydride / 1,2-dichloro-ethane / 17 h / 20 °C / Inert atmosphere

With oxalyl dichloride; sodium tris(acetoxy)borohydride; In dichloromethane; 1,2-dichloro-ethane;

upstream raw materials:

5-methoxy-7-methyl-1H-indole

di-tert-butyl dicarbonate