13877-55-9

Basic information

• Product Name: 7H-PYRAZOLO[4,3-D]PYRIMIDIN-7-ONE, 1,4-DIHYDRO-
• Synonyms: 7H-PYRAZOLO[4,3-D]PYRIMIDIN-7-ONE, 1,4-DIHYDRO-;7H-Pyrazolo[4,3-d]pyrimidin-7-one, 1,4-dihydro- (9CI);7-ketopyrazolo(4,3-d)pyrimidine;7H-Pyrazolo[4,3-d]pyrimidin-7-one;1,4-Dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one;7-Hydroxypyrazolo[4,3-d]pyrimidine;1H-Pyrazolo(4,3-D)pyrimidin-7-ol (8ci);1H-Pyrazolo(4,3-D)pyrimidine-7-one
• CAS NO: 13877-55-9
• Molecular Formula: C₅H₄N₄O
• Molecular Weight: 136.11
• Product Categories: PYRIMIDINE;Heterocycle-Pyrimidine series
• Mol File: 13877-55-9.mol

Chemical Properties

• Melting Point: >30 °C(Solv: water (7732-18-5))
• Boiling Point: 463.5°Cat760mmHg
• Flash Point: 234.1°C
• Appearance: /
• Density: 1.89g/cm³
• Vapor Pressure: 0.036mmHg at 25°C
• Refractive Index: 1.903
• Storage Temp.: 2-8°C
• PKA: 10.66±0.20(Predicted)
• CAS DataBase Reference: 7H-PYRAZOLO[4,3-D]PYRIMIDIN-7-ONE, 1,4-DIHYDRO-(CAS DataBase Reference)
• NIST Chemistry Reference: 7H-PYRAZOLO[4,3-D]PYRIMIDIN-7-ONE, 1,4-DIHYDRO-(13877-55-9)
• EPA Substance Registry System: 7H-PYRAZOLO[4,3-D]PYRIMIDIN-7-ONE, 1,4-DIHYDRO-(13877-55-9)

Safety Data

• Hazardous Substances Data: 13877-55-9(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
7H-PYRAZOLO[4,3-D]PYRIMIDIN-7-ONE, 1,4-DIHYDROis used as a pharmaceutical agent for its potential antiviral and anticancer properties. Its ability to inhibit the enzyme dihydroorotate dehydrogenase (DHODH) makes it a valuable compound in the development of new treatments for viral infections and cancer.
Used in Medicinal Chemistry Research:
7H-PYRAZOLO[4,3-D]PYRIMIDIN-7-ONE, 1,4-DIHYDROis utilized as a research compound in medicinal chemistry to explore its structure-activity relationships and optimize its inhibitory activity against DHODH. This research aims to improve the compound's potency, selectivity, and pharmacokinetic properties, ultimately leading to the development of more effective drugs.
Used in Drug Discovery:
7H-PYRAZOLO[4,3-D]PYRIMIDIN-7-ONE, 1,4-DIHYDROserves as a starting point in drug discovery efforts, where its unique structure and biological activity are leveraged to identify novel therapeutic agents. By understanding its interactions with target proteins and optimizing its chemical properties, researchers can develop new drugs with improved efficacy and safety profiles.

InChI:InChI=1/C5H2N4O/c10-5-4-3(1-8-9-4)6-2-7-5/h1-2H

Upstream product

• 67221-50-5 4-aminopyrazole-3-carboxamide 
• 77287-34-4 formamide 
• 116008-52-7 4-amino-1H-pyrazole-3-carboxylic acid 
• 923283-63-0 C₁₀H₁₅N₃O₄ 
• 3473-63-0 formamidine acetic acid 
• 55904-61-5 4-amino-1H-pyrazole-3-carboxylic acid ethyl ester 

Downstream Products

• 142189-88-6 3-iodopyrazolo<4,3-d>pyrimidin-7-one 
• 142189-89-7 3-iodo-1-<(1,1-dimethylethyl)diphenylsilyl>-7-<<(1,1-dimethylethyl)diphenylsilyl>oxy>pyrazolo<4,3-d>pyrimidine 
• 5399-92-8 4-chloro-1H-pyrazolo[3,4-d]pyrimidine 
• 923282-64-8 7-chloro-1H-pyrazolo[4,3-d]pyrimidine 
• 13877-56-0 7-aminopyrazolo<4,3-d>pyrimidine 

Relevant articles and documents

Pyrazolo pyrimidines useful as aurora kinase inhibitors

The present invention provides compounds having the formula: wherein A-B together represent one of the following structures: wherein one of is a double bond, as valency permits; and R2, R4, X1A, X2A, X1B, X2B, L1, L2, Y and Z are as defined in classes and subclasses herein, and pharmaceutical compositions thereof, as described generally and in subclasses herein, which compounds are useful as inhibitors of protein kinase (e.g., Aurora), and thus are useful, for example, for the treatment of Aurora mediated diseases.