1392429-79-6

Basic information

• Product Name: BI 882370
• Synonyms: BI 882370
• CAS NO: 1392429-79-6
• Molecular Formula: C₂₈H₃₃F₂N₇O₂S
• Molecular Weight: 569.6691264
• EINECS: -0
• Mol File: 1392429-79-6.mol

Chemical Properties

• Boiling Point: 649.6±65.0 °C(Predicted)
• Appearance: /
• Density: 1.37±0.1 g/cm3(Predicted)
• PKA: 5.48±0.10(Predicted)
• CAS DataBase Reference: BI 882370(CAS DataBase Reference)
• NIST Chemistry Reference: BI 882370(1392429-79-6)
• EPA Substance Registry System: BI 882370(1392429-79-6)

Safety Data

• Hazardous Substances Data: 1392429-79-6(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
BI 882370 is used as an anticancer agent for targeting B-RAF-mutant melanoma and colorectal carcinoma. It inhibits the proliferation of human B-RAF-mutant melanoma cells and reduces tumor growth in mouse xenograft models, making it a promising candidate for cancer treatment.
Additionally, BI 882370 is used in combination therapies with trametinib for inducing tumor regression in A375 melanoma mouse xenograft models, showcasing its potential in overcoming resistance and enhancing treatment efficacy.

Upstream product

• 946826-47-7 N-(3-amino-2,6-difluorophenyl)acetamide 
• 25892-08-4 N-(2,6-difluoro-3-nitrophenyl)acetamide 
• 1383745-37-6 N-(2,6-difluoro-3-(propylsulfonamido)phenyl)acetamide 
• 1392429-92-3 N-(2,4-difluoro-3-iodophenyl) propane-1-sulfonamide 
• 1392429-97-8 4-((1-(2,6-difluoro-3-(propylsulfonamido)phenyl)-1H-pyrrolo[3,2-b]pyridin-5-yl)(methyl)amino)piperidine-1-carboxylic acid tert-butyl ester 
• 1392429-98-9 4-((1-(2,6-difluoro-3-(propylsulfonamido)phenyl)-3-iodo-1H-pyrrolo[3,2- b]pyridin-5-yl)(methyl)amino)piperidine-1-carboxylic acid tert-butyl ester 
• 1392429-50-3 4-((1-(2,6-difluoro-3-(propylsulfonamido)phenyl)-3-(pyrimidin-5-yl)-1H-pyrrolo[3,2-b]pyridin-5-yl)(methyl)amino)piperidine-1-carboxylic acid tert-butyl ester 
• 1392429-51-4 N-(2,4-difluoro-3-(5-(methyl(piperidin-4-yl)amino)-3-(pyrimidin-5-yl)-1H- pyrrolo[3,2-b]pyridin-1-yl)phenyl)propane-1-sulfonamide 
• 75-07-0 acetaldehyde 

Relevant articles and documents

CRYSTALLINE SALTS OF A B-RAF KINASE INHIBITOR

The present invention is related to crystalline salts of N-(3-(5-((1-ethylpiperidin-4-yl)(methyl)amino)-3-(pyrimidin-5-yl)-1H-pyrrolo[3,2-b]pyridin-1-yl)-2,4-difluorophenyl)propane-1-sulfonamide, a RAF kinase Inhibitor, useful in the treatment of cancer and other diseases.

NEW AZAINDOLYLPHENYL SULFONAMIDES AS SERINE/THREONINE KINASE INHIBITORS

The present invention encompasses compounds of general formula (I) wherein the groups R2 to R6, A, X, Y and m are defined as in claim 1, which are suitable for the treatment of diseases characterised by excessive or abnormal cell proliferation, pharmaceutical preparations which contain compounds of this kind and their use as medicaments.