139272-29-0

Basic information

• Product Name: 4-Hydrazino-N-methylbenzenemethanesulfonamide
• Synonyms: 4-HYDRAZINO-N-METHYLBENZENEMETHANESULFONAMIDE(FOR SUMATRIPTAN);4-hydrazinophenyl-N-methyl-methanesulphonamide;4-Hydrazino-N-mehtyl-benzenmethanesulphonamide;p-Hydrazino-N-methylbenzenesulfonamide;4-HYDRAZINO-BENZENE METHANE SULFONAMIDEN-METHYL HCL;4-Hydrazino-N-methylbenzenemethanesulfonamide;1-(4-Hydrazinylphenyl)-N-MethylMethanesulfonaMide;4-hydrazinyl-N-methylBenzenemethanesulfonamide
• CAS NO: 139272-29-0
• Molecular Formula: C₈H₁₃N₃O₂S
• Molecular Weight: 215.27
• Mol File: 139272-29-0.mol

Chemical Properties

• Boiling Point: 427.4 °C at 760 mmHg
• Flash Point: 212.3 °C
• Appearance: /
• Density: 1.356 g/cm³
• Vapor Pressure: 1.64E-07mmHg at 25°C
• Refractive Index: 1.619
• Storage Temp.: 2-8°C
• PKA: 11.47±0.40(Predicted)
• CAS DataBase Reference: 4-Hydrazino-N-methylbenzenemethanesulfonamide(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Hydrazino-N-methylbenzenemethanesulfonamide(139272-29-0)
• EPA Substance Registry System: 4-Hydrazino-N-methylbenzenemethanesulfonamide(139272-29-0)

Safety Data

• Hazardous Substances Data: 139272-29-0(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Development:
4-Hydrazino-N-methylbenzenemethanesulfonamide is used as a potential candidate in the development of new drugs due to its unique chemical structure and potential biological activity. Its sulfonamide and hydrazine groups may contribute to its therapeutic properties, making it a valuable compound for medicinal chemistry research.
Used in Medicinal Chemistry Research:
As a derivative of sulfonamide, 4-Hydrazino-N-methylbenzenemethanesulfonamide is used as a research tool in medicinal chemistry to study its potential interactions with biological targets and its effects on various biological processes. Its unique structure allows researchers to investigate its potential as a lead compound for the development of novel therapeutic agents.
Used in Biological Studies:
4-Hydrazino-N-methylbenzenemethanesulfonamide is used in biological studies to explore its potential effects on cellular processes and its interactions with biomolecules. Its hydrazine and methyl groups may provide insights into its binding properties and its ability to modulate biological pathways, contributing to a better understanding of its potential applications in medicine.

InChI:InChI=1/C8H13N3O2S/c1-10-14(12,13)6-7-2-4-8(11-9)5-3-7/h2-5,10-11H,6,9H2,1H3

Upstream product

• 109903-35-7 1-(4-aminophenyl)-N-methylmethanesulfonamide 
• 103360-04-9 4-fluorobenzylsulfonyl chloride 
• 1064778-57-9 C₇H₇FO₃S 
• 352-11-4 1-chloromethyl-4-fluorobenzene 

Downstream Products

• 103628-46-2 sumatripan 
• 88919-22-6 3-(2-aminoethyl)-1H-indole-5-yl-N-methyl methane sulphonamide 
• 88919-51-1 N-methyl-2-[5-[[(methylamino)sulphonyl]methyl]-1H-indol-3-yl]ethanamine 
• 1234737-40-6 1-[4-[(methylaminosulfonyl)methyl]phenyl]-1H-pyrazole-4-carboxamide 
• 1338815-24-9 1-(4-(5-amino-3-tert-butyl-1H-pyrazol-1-yl)phenyl)-N-methyl methanesulfonamide 

Relevant articles and documents

4-Hydroxy-2-Methyl-3(2H)-Isothiazolone-1,1-Dioxide as Protecting Group of 4-(N-Methylaminosulfonyl)methylphenylhydrazine during Fischer Indole Synthesis

Protection of the benzylic position of 4-methylaminosulfonylmethylphenyl hydrazine 6 with a 4-hydroxy-2-methyl-3(2H)-isothiazolone-1,1-dioxide group allowed the preparation of indole 3 without formation of side-product.

Simple preparation method of p-hydrazinobenzenesulfonic acid compound

The invention provides a preparation method of a p-hydrazinobenzenesulfonic acid compound. P-fluorobenzyl chloride is used as an initial raw material, and a target product is obtained through sulfonation, acylating chlorination, condensation, substitution and other methods. The raw materials are easy to obtain, the operation is easy and convenient, the cost is low, the risk is low, and the compound has a wide application prospect in the field of medicinal chemistry.

RESPIRATORY FORMULATIONS AND COMPOUNDS FOR USE THEREIN

The present invention relates to respiratory formulations comprising a compound of formula (I): and use of said compounds and compositions in treatment, for example in the treatment of an inflammatory disease or a respiratory disorder, in particular an inflammatory mediated and/or virally mediated respiratory disorder such as asthma and COPD or the treatment or prevention of viral infection, for example infection by influenza virus, rhinovirus or RSV. The invention also extends to certain novel compounds of formula (I).

P38 MAP KINASE INHIBITORS

There is provided a compound of formula (I): wherein: J represents (A): or (B): compositions comprising same, processes for preparing said compounds and use thereof in treatment, particularly in the treatment of inflammatory disease, such as asthma, COPD and 15 rheumatoid arthritis.

RESPIRATORY FORMULATIONS AND COMPOUNDS FOR USE THEREIN

The present invention relates to respiratory formulations comprising a compound of formula (I): and use of said compounds and compositions in treatment, for example in the treatment of an inflammatory disease or a respiratory disorder, in particular an inflammatory mediated and/or virally mediated respiratory disorder such as asthma and COPD or the treatment or prevention of viral infection, for example infection by influenza virus, rhinovirus or RSV. The invention also extends to certain novel compounds of formula (I).

N-Desmethyltriptans: One pot efficient synthesis of N-methyl-2-5- [substituted- 1H- indole-3-yl]ethanamines

A straightforward and highly improved method to synthesize N-methyl-2-[5-[substituted-lH-indole-3-yl]ethanamines 4-6, which are the metabolites of tryptans 1-3, is reported. The significance of the process is its simplicity and efficiency in isolating the N- desmethyltriptans derivatives as a free base.