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4-BIPHENYLACETIC ACID HYDRAZIDE, also known as biphenylacetic acid hydrazide, is a chemical compound with a diverse range of potential applications in the medical field. It is recognized for its potential as a drug and anti-inflammatory agent, with the ability to inhibit the production of leukotrienes, which play a role in inflammatory and allergic reactions. Additionally, this compound has shown promise as an anti-cancer agent, with studies indicating its effectiveness in inhibiting the growth of certain cancer cells. Furthermore, 4-BIPHENYLACETIC ACID HYDRAZIDE has been investigated for its potential in treating respiratory and cardiovascular diseases, and it has demonstrated potential as an analgesic and antipyretic agent, highlighting its versatility in medical applications.

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  • 139277-58-0 Structure
  • Basic information

    1. Product Name: 4-BIPHENYLACETIC ACID HYDRAZIDE
    2. Synonyms: 4-BIPHENYLACETIC ACID HYDRAZIDE;4-BIPHENYLACETIC HYDRAZIDE;AKOS B015277;ART-CHEM-BB B015277;CHEMBRDG-BB 3015277;2-biphenyl-4-ylacetohydrazide(SALTDATA: FREE);2-(4-phenylphenyl)acetohydrazide;2-(4-phenylphenyl)ethanehydrazide
    3. CAS NO:139277-58-0
    4. Molecular Formula: C14H14N2O
    5. Molecular Weight: 226.27
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 139277-58-0.mol
  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: 473.9 °C at 760 mmHg
    3. Flash Point: 240.4 °C
    4. Appearance: /
    5. Density: 1.147 g/cm3
    6. Vapor Pressure: 3.79E-09mmHg at 25°C
    7. Refractive Index: 1.601
    8. Storage Temp.: N/A
    9. Solubility: N/A
    10. CAS DataBase Reference: 4-BIPHENYLACETIC ACID HYDRAZIDE(CAS DataBase Reference)
    11. NIST Chemistry Reference: 4-BIPHENYLACETIC ACID HYDRAZIDE(139277-58-0)
    12. EPA Substance Registry System: 4-BIPHENYLACETIC ACID HYDRAZIDE(139277-58-0)
  • Safety Data

    1. Hazard Codes: Xi
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: IRRITANT
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 139277-58-0(Hazardous Substances Data)

139277-58-0 Usage

Uses

Used in Pharmaceutical Industry:
4-BIPHENYLACETIC ACID HYDRAZIDE is used as a drug candidate for its potential anti-inflammatory properties, targeting the inhibition of leukotriene production to alleviate inflammatory and allergic reactions in the body.
Used in Oncology:
4-BIPHENYLACETIC ACID HYDRAZIDE is used as an anti-cancer agent, showing promising results in inhibiting the growth of specific cancer cells, which could contribute to the development of novel cancer therapies.
Used in Respiratory Disease Treatment:
4-BIPHENYLACETIC ACID HYDRAZIDE is used as a potential treatment for respiratory diseases, given its capacity to impact biological pathways relevant to such conditions.
Used in Cardiovascular Disease Treatment:
4-BIPHENYLACETIC ACID HYDRAZIDE is used as a potential therapeutic agent for cardiovascular diseases, suggesting its role in managing or treating conditions related to the heart and blood vessels.
Used as an Analgesic:
4-BIPHENYLACETIC ACID HYDRAZIDE is used as an analgesic agent, leveraging its pain-relieving properties to address various types of pain.
Used as an Antipyretic:
4-BIPHENYLACETIC ACID HYDRAZIDE is used as an antipyretic agent, helping to reduce fever by addressing the underlying causes of elevated body temperature.

Check Digit Verification of cas no

The CAS Registry Mumber 139277-58-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,3,9,2,7 and 7 respectively; the second part has 2 digits, 5 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 139277-58:
(8*1)+(7*3)+(6*9)+(5*2)+(4*7)+(3*7)+(2*5)+(1*8)=160
160 % 10 = 0
So 139277-58-0 is a valid CAS Registry Number.
InChI:InChI=1/C14H14N2O/c15-16-14(17)10-11-6-8-13(9-7-11)12-4-2-1-3-5-12/h1-9H,10,15H2,(H,16,17)

139277-58-0SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 12, 2017

Revision Date: Aug 12, 2017

1.Identification

1.1 GHS Product identifier

Product name 2-(4-phenylphenyl)acetohydrazide

1.2 Other means of identification

Product number -
Other names [1,1'-Biphenyl]-4-aceticacid,hydrazide

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:139277-58-0 SDS

139277-58-0Relevant articles and documents

Synthesis and structure-activity relationships of 3,4,5-trisubstituted-1,2,4-triazoles: High affinity and selective somatostatin receptor-4 agonists for Alzheimer's disease treatment

Crider, A. Michael,Farr, Susan A.,Frare, Rafael,Hospital, Audrey,Kontoyianni, Maria,Kukielski, Stephen G.,Minaeian, Mahsa,Mobayen, Shirin,Neumann, William L.,Niehoff, Michael L.,Sandoval, Karin E.,Slater, Olivia,Srabony, Khush N.,Witt, Ken A.

, p. 1352 - 1365 (2021/11/09)

Somatostatin receptor-4 (SST4) is highly expressed in brain regions affiliated with learning and memory. SST4 agonist treatment may act to mitigate Alzheimer's disease (AD) pathology. An integrated approach to SST4 agonist lead optimization is presented herein. High affinity and selective agonists with biological efficacy were identified through iterative cycles of a structure-based design strategy encompassing computational methods, chemistry, and preclinical pharmacology. 1,2,4-Triazole derivatives of our previously reported hit (4) showed enhanced SST4 binding affinity, activity, and selectivity. Thirty-five compounds showed low nanomolar range SST4 binding affinity, 12 having a Ki 500-fold affinity for SST4 as compared to SST2A. SST4 activities were consistent with the respective SST4 binding affinities (EC50 600-fold selectivity over SST2A) display a favorable physiochemical profile, and was advanced to learning and memory behavior evaluations in the senescence accelerated mouse-prone 8 model of AD-related cognitive decline. Chronic administration enhanced learning with i.p. dosing (1 mg kg-1) compared to vehicle. Chronic administration enhanced memory with both i.p. (0.01, 0.1, 1 mg kg-1) and oral (0.01, 10 mg kg-1) dosing compared to vehicle. This study identified a novel series of SST4 agonists with high affinity, selectivity, and biological activity that may be useful in the treatment of AD. This journal is

Studies and synthesis of substituted 4-biphenyl acetamide derivatives

Khullar, Anju

, p. 510 - 514 (2019/02/06)

A new series of substituted 4-biphenylamides have been synthesized by condensation of 4-biphenyl acetic acid with different primary amines (aromatic and aliphatic). 4-Biphenyl acetic acid was first treated with thionyl chloride in dry benzene to prepare substituted 4-biphenyl acetyl chloride, which is then treated with different aliphatic or aromatic amines to synthesize various substituted 4-biphenyl acid-amide derivatives. The structure of newly synthesized compounds has been established by analytical and spectral methods. These synthesized compounds have shown antifungal properties against Fusarium udum and Curvularia lunata.

3,4,5-TRISUBSTITUTED-1,2,4-TRIAZOLES AND 3,4,5-TRISUBSTITUTED-3-THIO-1,2,4-TRIAZOLES AND USES THEREOF

-

Paragraph 0158; 0193; 0206, (2018/12/02)

The present disclosure describes novel compounds that are somatostatin receptor type 4 agonists.

Aggrecanase-2 inhibitors based on the acylthiosemicarbazide zinc-binding group

Maingot, Lucie,Elbakali, Jamal,Dumont, Julie,Bosc, Damien,Cousaert, Nicolas,Urban, Agathe,Deglane, Gaelle,Villoutreix, Bruno,Nagase, Hideaki,Sperandio, Olivier,Leroux, Florence,Deprez, Benoit,Deprez-Poulain, Rebecca

, p. 244 - 261 (2013/10/01)

Osteoarthritis is a disabling disease characterized by the articular cartilage breakdown. Aggrecanases are potential therapeutic targets for the treatment of this pathology. At the starting point of this project, an acylthiosemicarbazide was discovered to inhibit aggrecanase-2. The acylthiosemicarbazide Zn binding group is also a convenient linker for library synthesis. A focused library of 920 analogs was thus prepared and screened to establish structure-activity relationships. The modification of the acylthiosemicarbazide was also explored. This strategy combining library design and discrete compounds synthesis yielded inhibitor 35, that is highly selective for aggrecanases over a panel of metalloproteases and inhibits the degradation of native fully glycosylated aggrecan. A docking study generated binding conformations explaining the structure-activity relationships.

Aromatic hydrazides as specific inhibitors of bovine serum amine oxidase

Artico,Silvestri,Stefancich,Avigliano,Di Giulio,Maccarrone,Agostinelli,Mondovi,Morpurgo

, p. 219 - 228 (2007/10/02)

New hydrazides were synthesized in search for specific inhibitors of bovine serum amine oxidase: a series of benzoic and phenylacetic acid hydrazides containing the 1H-imidazol-1-yl or the 1H-imidazol-1-ylmethyl group as (o,m,p)-substituent in the phenyl ring; an analogous series of p-substituted phenylhydrazides with 5 or 6-membered heterocyclic ring as substituent, and a series of similar phenylpropionic hydrazides. The longer and more flexible phenylacetic hydrazides, and to a somewhat lesser extent the phenylpropionic ones, were better specific inhibitors of bovine serum amine oxidase than the benzoic hydrazides, which were also bound by the enzyme with high affinity, but at a slow rate. Derivatives with p- and m-substituents were more reactive than the o-substituted ones. The chemical nature of the substituent was less important than its position in the phenyl ring and the presence of methylene spacers. These data point to the presence of a hydrophobic site at short distance from the protein carbonyl cofactor, so that simultaneous interaction of the 2 ends of the inhibitor molecule can occur at the 2 sites. The presence of the hydrophobic site was confirmed by the capability of some molecule deprived of the hydrazidic group to act as mild inhibitors. All hydrazides were less reactive by 2-3 orders of magnitude towards pig kidney diamine oxidase and FAD-dependent monoamine oxidase from rat brain mitochondria, while the other compounds showed similar inhibition power against all proteins. The specificity for the bovine enzyme seems therefore to be related to the concerted action of the 2 moieties of the inhibitor molecule.

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