14062-23-8

Basic information

• Product Name: felbinacethyl
• Synonyms: 4-Biphenylacetic acid ethyl ester;felbinacethyl;4-Ethyl Biphenyl Acetate;Felbinaethyl;4-biphenylylacetic acid ethyl ester;Felbinac ethyl ester;ETHYL 2-(BIPHENYL-4-YL)ACETATE;D01841
• CAS NO: 14062-23-8
• Molecular Formula: C₁₆H₁₆O₂
• Molecular Weight: 240.29704
• Product Categories: Biphenyl & Diphenyl ether
• Mol File: 14062-23-8.mol
• Article Data: 31

Chemical Properties

• Boiling Point: 357.2 °C at 760 mmHg
• Flash Point: 144.1 °C
• Appearance: /
• Density: 1.072g/cm³
• Vapor Pressure: 2.77E-05mmHg at 25°C
• Refractive Index: 1.55
• CAS DataBase Reference: felbinacethyl(CAS DataBase Reference)
• NIST Chemistry Reference: felbinacethyl(14062-23-8)
• EPA Substance Registry System: felbinacethyl(14062-23-8)

Safety Data

• Hazardous Substances Data: 14062-23-8(Hazardous Substances Data)

Usage

General Description

"felbinacethyl" is a chemical compound that is synthesized from a combination of felbinac and ethyl. Felbinac is a nonsteroidal anti-inflammatory drug (NSAID) that is used to reduce pain and inflammation. Ethyl, on the other hand, is a chemical group derived from ethanol that is often used in the synthesis of various pharmaceuticals and organic compounds. The combination of these two compounds is designed to enhance the anti-inflammatory and analgesic properties of felbinac, making it more effective for pain relief and reducing inflammation. This chemical compound has potential applications in the development of new pharmaceutical drugs for managing pain and inflammatory conditions.

InChI:InChI=1/C16H16O2/c1-2-18-16(17)12-13-8-10-15(11-9-13)14-6-4-3-5-7-14/h3-11H,2,12H2,1H3

Upstream product

• 5122-94-1 4-biphenylboronic acid 
• 616-27-3 1-chlorobutan-2-one 
• 92-66-0 4-bromo-1,1'-biphenyl 
• 105-53-3 diethyl malonate 
• 5728-52-9 (4-biphenylyl)acetic acid 
• 64-17-5 ethanol 
• 108-86-1 bromobenzene 
• 14062-25-0 Ethyl 4-bromophenylacetate 
• 17889-23-5 4-(trimethylsilyl)aniline 
• 1625-88-3 4-(trimethylsilyl)biphenyl 
• 141-97-9 ethyl acetoacetate 
• 623-73-4 diazoacetic acid ethyl ester 
• 92-52-4 biphenyl 
• 105-36-2 ethyl bromoacetate 

Downstream Products

• 5728-52-9 (4-biphenylyl)acetic acid 
• 6244-53-7 ethyl (4-phenylphenyl)glyoxylate 
• 1448068-28-7 ([1,1’-biphenyl]-4-yl)(1H-indol-3-yl)methanone 
• 26206-17-7 [1,1'-biphenyl]-4-yl(2-methyl-1H-indol-3-yl)methanone 
• 1380650-55-4 ethyl 1-(4-phenylphenyl)cyclopropanecarboxylate 
• 6317-76-6 [1,1'-biphenyl]-4-yl(4-nitrophenyl)methanone 
• 61502-90-7 4-Biphenylacetaldehyde 
• 1489288-73-4 1-(4-biphenylacetyl)-4-(4-chlorophenethyl)-thiosemicarbazide 
• 1489288-50-7 1-(4-biphenylacetyl)-4-cyclohexylbutyl-thiosemicarbazide 
• 1391911-24-2 C₂₁H₂₁NO₂S 
• 1314242-05-1 2-(4-biphenyl)-4-methyl-2H-1,4-benzothiazin-3(4H)-one 
• 1314242-04-0 2-(4-biphenyl)-2H-1,4-benzothiazin-3(4H)-one 
• 1314242-03-9 2-(4-biphenyl)-4-methyl-3,4-dihydro-2H-1,4-benzothiazine 
• 1314242-01-7 4-methyl-2-(4-biphenylyl)-3,4-dihydro-2H-1,4-benzothiazin-2-ol 

Relevant articles and documents

Photoassisted Cross-Coupling Reaction of α-Chlorocarbonyl Compounds with Arylboronic Acids

A Suzuki-Miyaura cross-coupling reaction of α-chloroacetates or α-chloroacetamides with arylboronic acids is made possible by visible-light irradiation. This reaction provides a useful method for the synthesis of α-arylacetates and α-arylacetamides from chlorides under mild reaction conditions. An indole-3-acetic acid derivative that is the key intermediate of the plant hormone auxin can be synthesized from 1-Boc-indole in two steps by combining an iridium-catalyzed C-H borylation and a palladium-catalyzed cross-coupling reaction.

Divergent Synthesis of α-Fluorinated Carbonyl and Carboxyl Derivatives by Double Electrophilic Activation of Amides

A straightforward and divergent entry to α-fluorinated carbonyl and carboxyl derivatives is reported. Upon activation of amides with triflic anhydride and a 2-halo-pyridine and subsequent trapping of the resulting keteniminium ions with nucleophiles followed by a second electrophilic activation with NFSI and final hydrolysis, a range of amides can be transformed to α-fluorinated ketones, esters, and amides under mild conditions. Moreover, this reaction can be performed to yield enantioenriched products with a traceless chiral auxiliary.

Photocatalytic acyl azolium-promoted alkoxycarbonylation of trifluoroborates

Despite recent advancements in the selective generation and coupling of organic radical species, the alkoxycarbonyl radical remains underexplored relative to other carbon-containing radical species. Drawing inspiration from new strategies for generating acyl radical equivalents utilizing dual N-heterocyclic carbene catalysis and photocatalysis, we have prepared dimethylimidazolium esters that can function as an alkoxycarbonyl radical surrogate under photocatalytic conditions. We demonstrate the synthetic utility of these azolium-based partners through the preparation of esters arising from the coupling of this radical surrogate with an oxidatively generated alkyl radical.