139419-02-6

Basic information

• Product Name: Uridine, 4'-C-azido-5'-deoxy-5'-iodo-, 2',3'-dibenzoate
• Synonyms: Uridine, 4'-C-azido-5'-deoxy-5'-iodo-, 2',3'-dibenzoate;(2S,3S,4R,5R)-2-azido-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-2-(iodomethyl)tetrahydrofuran-3,4-diyl dibenzoate
• CAS NO: 139419-02-6
• Molecular Formula: C₂₃H₁₈IN₅O₇
• Molecular Weight: 603.32279
• Mol File: 139419-02-6.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Uridine, 4'-C-azido-5'-deoxy-5'-iodo-, 2',3'-dibenzoate(CAS DataBase Reference)
• NIST Chemistry Reference: Uridine, 4'-C-azido-5'-deoxy-5'-iodo-, 2',3'-dibenzoate(139419-02-6)
• EPA Substance Registry System: Uridine, 4'-C-azido-5'-deoxy-5'-iodo-, 2',3'-dibenzoate(139419-02-6)

Safety Data

• Hazardous Substances Data: 139419-02-6(Hazardous Substances Data)

Usage

Uses

Used in Chemical and Biological Research:
Uridine, 4'-C-azido-5'-deoxy-5'-iodo-, 2',3'-dibenzoate is used as a research tool for studying the structure and function of nucleic acids. Its modified structure provides a means to explore nucleic acid-protein interactions, which is crucial for understanding the molecular mechanisms underlying various biological processes.
Used in Biotechnology and Medical Applications:
Uridine, 4'-C-azido-5'-deoxy-5'-iodo-, 2',3'-dibenzoate is employed as a component in the development of new tools and technologies within biotechnology and medicine. Its unique properties allow for the creation of novel diagnostic and therapeutic agents, potentially leading to advancements in healthcare.
Used in Pharmaceutical Development:
Uridine, 4'-C-azido-5'-deoxy-5'-iodo-, 2',3'-dibenzoate serves as a building block for the synthesis of other nucleoside analogs and derivatives. These synthesized compounds may have potential pharmaceutical uses, offering new avenues for the treatment of various diseases and conditions.
Used in Diagnostic Applications:
Uridine, 4'-C-azido-5'-deoxy-5'-iodo-, 2',3'-dibenzoate's structure makes it a candidate for the development of diagnostic tools, where its interaction with specific biological targets can be exploited to detect or monitor diseases, contributing to the field of medical diagnostics.

Upstream product

• 98-88-4 benzoyl chloride 
• 139419-04-8 4'-azido-5'-deoxy-5'-iodouridine 
• 14365-63-0 5'-deoxyuridin-4'-ene 
• 14259-58-6 1-((2R,3R,4S,5S)-3,4-dihydroxy-5-iodomethyl-tetrahydro-furan-2-yl)-1H-pyrimidine-2,4-dione 

Downstream Products

• 1365255-42-0 C₃₀H₂₃N₅O₉ 
• 690270-09-8 benzoic acid (2R,3S,4R,5R)-2-azido-3,4-dibenzoyloxy-5-(4-benzoylamino-2-oxo-2H-pyrimidin-1-yl)-tetrahydrofuran-2-ylmethyl ester 
• 812647-80-6 1-(4’-azido-5‘-O-(3-chloro)benzoyl-2’,3‘-O-dibenzoyl-β-D-ribofuranosyl)uracil 
• 478182-28-4 4'-azidocytidine 
• 478182-26-2 C₂₃H₁₉N₅O₈ 
• 139442-01-6 1-(4'-azido-β-D-ribofuranosyl)uracil 

Relevant articles and documents

Azido nucleosides and nucleotide analogs

Disclosed herein are 4′-azido-substituted nucleosides, nucleotides and analogs thereof, pharmaceutical compositions that include one or more of 4′-azido-substituted nucleosides, nucleotides and analogs thereof, and methods of synthesizing the same. Also disclosed herein are methods of ameliorating and/or treating a disease and/or a condition, including an infection from a paramyxovirus and/or an orthomyxovirus, with a 4′-azido-substituted nucleoside, a nucleotide and/or an analog thereof. Examples of viral infections include a respiratory syncytial viral (RSV) and influenza infection.

Design, synthesis, and antiviral properties of 4′-substituted ribonucleosides as inhibitors of hepatitis C virus replication: The discovery of R1479

A series of 4′-substituted ribonucleoside derivatives has been prepared and evaluated for inhibition of hepatitis C virus (HCV) RNA replication in cell culture. The most potent and non-cytotoxic derivative was compound 28 (4′-azidocytidine, R1479) with an

Anti-viral nucleosides

4-Amino-1-((2R,3S,4S,5R)-5-azido-3,4-dihydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-1H-pyrimidin-2-one (I:R1=R2=R3=R4=H) and prodrugs thereof are hepatitis C(HCV) polymerase inhibitors. Also disclosed are comp

PROCESSES FOR PREPARING 4’AZIDO NUCLEOSIDE DERIVATIVES

A process for the preparation of a 4’-azido-2’,3’,5’-triacyl-nucleoside compound (I;B=B1; R1 is R1aCO-and R2 is R2aCO-) or a 4’-azidonucleoside compounds (I; B is B1 or B2 and R1 and R2 are

4'-substituted nucleoside derivatives as inhibitors of HCV RNA replication

The present invention relates to the use of nucleoside derivatives of formula I wherein B signifies a 9-purinyl residue B1 of formula or a 1-pyrimidyl residue B2 of formula wherein the symbols are as defined in the specification, and of pharmaceutically a

Synthesis and anti-HIV activity of 4'-azido- and 4'-methoxynucleosides

A series of nucleosides were synthesized in which the 4'-hydrogen was substituted with either an azido or a methoxy group. The key steps in the syntheses of the 4'-azido analogues were the stereo- and regioselective addition of iodine azide to a 4'-unsatu