1401163-85-6

Basic information

• Product Name: [2-(2,2,2-TRIFLUOROETHOXY)PYRIMIDIN-5-YL]BORONIC ACID
• Synonyms: [2-(2,2,2-TRIFLUOROETHOXY)PYRIMIDIN-5-YL]BORONIC ACID;2-(2,2,2-Trifluoroethoxy)pyrimidine-5-boronic acid
• CAS NO: 1401163-85-6
• Molecular Formula: C6H6BF3N2O3
• Molecular Weight: 221.9296496
• Mol File: 1401163-85-6.mol

Chemical Properties

• Boiling Point: 348.4±52.0 °C(Predicted)
• Appearance: /
• Density: 1.50±0.1 g/cm3(Predicted)
• Storage Temp.: Refrigerated.
• PKA: 5.21±0.18(Predicted)
• CAS DataBase Reference: [2-(2,2,2-TRIFLUOROETHOXY)PYRIMIDIN-5-YL]BORONIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: [2-(2,2,2-TRIFLUOROETHOXY)PYRIMIDIN-5-YL]BORONIC ACID(1401163-85-6)
• EPA Substance Registry System: [2-(2,2,2-TRIFLUOROETHOXY)PYRIMIDIN-5-YL]BORONIC ACID(1401163-85-6)

Safety Data

• Hazardous Substances Data: 1401163-85-6(Hazardous Substances Data)

Usage

Uses

Used in Organic and Medicinal Chemistry:
[2-(2,2,2-TRIFLUOROETHOXY)PYRIMIDIN-5-YL]BORONIC ACID is used as a building block for the synthesis of various pharmaceuticals and agrochemicals, contributing to the development of new drugs and pesticides.
Used in Material Science:
In the field of material science, [2-(2,2,2-TRIFLUOROETHOXY)PYRIMIDIN-5-YL]BORONIC ACID is utilized in the development of novel materials, potentially enhancing properties such as stability, reactivity, or selectivity in various applications.
Used in Catalysis:
This boronic acid compound is also employed in catalysis, particularly in cross-coupling reactions, where it can facilitate the formation of new chemical bonds, leading to the synthesis of complex organic molecules.
Used in Chemical Research and Drug Discovery:
The boronic acid functional group of [2-(2,2,2-TRIFLUOROETHOXY)PYRIMIDIN-5-YL]BORONIC ACID allows for the formation of strong covalent bonds with other molecules, making it a valuable tool in chemical research and drug discovery for exploring new chemical spaces and developing innovative therapeutic agents.

Upstream product

• 433683-47-7 5-bromo-2-(2,2,2-trifluoroethoxy)pyrimidine 
• 73183-34-3 bis(pinacol)diborane 

Relevant articles and documents

HETEROCYCLIC COMPOUNDS AS DELTA-5 DESATURASE INHIBITORS AND METHODS OF USE

The present disclosure provides compounds useful for the inhibition of Delta-5 Desaturase ("D5D"). The compounds have a general Formula (I): wherein the variables of Formula (I) are defined herein. This disclosure also provides pharmaceutical compositions comprising the compounds, uses of the compounds, and compositions for treatment of, for example, a metabolic or cardiovascular disorder. Further, the disclosure provides intermediates useful in the synthesis of compounds of Formula (I).

SUBSTITUTED PYRIDAZINONE FOR USE IN THE TREATMENT OF NEUROMUSCULAR DISEASES

Substituted pyridazinone compounds, conjugates, and pharmaceutical compositions for use in the treatment of neuromuscular diseases, such as Duchenne Muscular Dystrophy (DMD), are disclosed herein. The disclosed compounds are useful, among other things, in the treating of DMD and modulating inflammatory inhibitors IL-1, IL-6 or TNF-α.

SUBSTITUTED PYRIDAZINONE FOR USE IN THE TREATMENT OF NEUROMUSCULAR DISEASES

Substituted pyridazinone compounds, conjugates, and pharmaceutical compositions for use in the treatment of neuromuscular diseases, such as Duchenne Muscular Dystrophy (DMD), are disclosed herein. The disclosed compounds are useful, among other things, in the treating of DMD and modulating inflammatory inhibitors IL-1, IL-6 or TNF-α.

PYRIDAZINONE COMPOUNDS AND USES THEREOF

Substituted pyridazinone compounds, conjugates, and pharmaceutical compositions for use in the treatment of neuromuscular diseases, such as Duchenne Muscular Dystrophy (DMD), are disclosed herein. The disclosed compounds are useful, among other things, in the treating of DMD and modulating inflammatory inhibitors IL-1, IL-6 or TNF-α.