[2-(2,2,2-TRIFLUOROETHOXY)PYRIMIDIN-5-YL]BORONIC ACID

Base Information

• Chemical Name: [2-(2,2,2-TRIFLUOROETHOXY)PYRIMIDIN-5-YL]BORONIC ACID
• CAS No.: 1401163-85-6
• Molecular Formula: C₆H₆BF₃N₂O₃
• Molecular Weight: 221.931
• Hs Code.: 2933599590
• Mol file: 1401163-85-6.mol

Synonyms:[2-(2,2,2-TRIFLUOROETHOXY)PYRIMIDIN-5-YL]BORONIC ACID;2-(2,2,2-Trifluoroethoxy)pyrimidine-5-boronic acid

Chemical Property of [2-(2,2,2-TRIFLUOROETHOXY)PYRIMIDIN-5-YL]BORONIC ACID

Chemical Property:

• Boiling Point: 348.4±52.0 °C(Predicted)
• PKA: 5.21±0.18(Predicted)
• PSA: 75.47000
• Density: 1.50±0.1 g/cm3(Predicted)
• LogP: -0.90250
• Storage Temp.: Refrigerated.

Purity/Quality:

97% ^*data from raw suppliers

2-(2,2,2-Trifluoroethoxy)pyrimidine-5-boronic acid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of [2-(2,2,2-TRIFLUOROETHOXY)PYRIMIDIN-5-YL]BORONIC ACID

There total 1 articles about [2-(2,2,2-TRIFLUOROETHOXY)PYRIMIDIN-5-YL]BORONIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

5-bromo-2-(2,2,2-trifluoroethoxy)pyrimidine (433683-47-7) + bis(pinacol)diborane (73183-34-3) → [2-(2,2,2-trifluoroethoxy)pyrimidin-5-yl]boronic acid (1401163-85-6)

Guidance literature:

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium acetate; In dichloromethane; at 90 ℃; for 3h;

upstream raw materials:

5-bromo-2-(2,2,2-trifluoroethoxy)pyrimidine

bis(pinacol)diborane