14016-29-6

Basic information

• Product Name: averufin
• Synonyms: averufin;3,4,5,6-Tetrahydro-7,9,11-trihydroxy-2-methyl-2,6-epoxy-2H-anthra[2,3-b]oxocin-8,13-dione;(1'S,5'S)-averufin
• CAS NO: 14016-29-6
• Molecular Formula: C₂₀H₁₆O₇
• Molecular Weight: 0
• Mol File: 14016-29-6.mol

Chemical Properties

• Boiling Point: 602.9°Cat760mmHg
• Flash Point: 220.8°C
• Appearance: /
• Density: 1.585g/cm³
• Vapor Pressure: 3.94E-15mmHg at 25°C
• Refractive Index: 1.718
• CAS DataBase Reference: averufin(CAS DataBase Reference)
• NIST Chemistry Reference: averufin(14016-29-6)
• EPA Substance Registry System: averufin(14016-29-6)

Safety Data

• Hazardous Substances Data: 14016-29-6(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
Averufin is used as a pharmaceutical compound for its potential therapeutic applications. Its unique structure and functional groups allow it to interact with various biological targets, making it a promising candidate for the development of new drugs and therapies.
Used in Anticancer Applications:
Averufin is used as an anticancer agent, targeting various types of cancer cells. It can modulate multiple oncological signaling pathways, leading to the inhibition of tumor growth and progression. Additionally, averufin may demonstrate synergistic effects when combined with conventional chemotherapeutic drugs, enhancing their efficacy and overcoming resistance in cancer treatment.
Used in Drug Delivery Systems:
To improve the delivery, bioavailability, and therapeutic outcomes of averufin, novel drug delivery systems have been developed. These systems employ various organic and metallic nanoparticles as carriers for averufin, aiming to enhance its overall effectiveness in treating cancer and other diseases.

InChI:InChI=1/C20H16O7/c1-20-4-2-3-12(26-20)16-13(27-20)7-10-15(19(16)25)18(24)14-9(17(10)23)5-8(21)6-11(14)22/h5-7,12,21-22,25H,2-4H2,1H3

Upstream product

• 67-56-1 methanol 

Downstream Products

• 74810-25-6 avefurin triacetate 
• 111975-78-1 1'-hydroxyversicolorone 

Relevant articles and documents

Quinofuracins A-E, produced by the fungus staphylotrichum boninense PF1444, show p53-dependent growth suppression

Quinofuracins A-E, novel anthraquinone derivatives containing β-d-galactofuranose that were isolated from the fungus Staphylotrichum boninense PF1444, induced p53-dependent cell death in human tumor cells. The structures of quinofuracins A-E, including absolute configurations, were elucidated by extensive spectroscopic analysis and chemical transformation studies. Quinofuracins were classified into three groups according to the aglycone moieties. 5'-Oxoaverantin was present in quinofuracins A-C, whereas averantin and versicolorin B were identified in quinofuracins D and E, respectively. These quinofuracins induced p53-dependent growth suppression in human glioblastoma LNZTA3 cells.