Br?nsted Acid Mediated Cascade Reaction to Access 3-(2-Bromoethyl)benzofurans
A unified protocol for the construction of 3-(2-bromoethyl)benzofurans and 2-(benzofuran-3-yl)ethylamines from bis[(trimethylsilyl)oxy]cyclobutene has been developed. This mild and facile strategy was applied for the synthesis of a series of 5-HT serotonin receptor agonists, underlining its potential for the syntheses of bioactive compounds and natural products.
Porcu, Stefania,Demuro, Stefania,Luridiana, Alberto,Cocco, Andrea,Frongia, Angelo,Aitken, David J.,Charnay-Pouget, Florence,Guillot, Regis,Sarais, Giorgia,Secci, Francesco
Benzofuran Bioisosteres of Hallucinogenic Tryptamines
The benzofuran analogues of the hallucinogens 5-methoxy-N,N-dimethyltryptamine and 5-methoxy-α-methyltryptamine were synthesized and evaluated for affinity at the serotonin 5-HT2 and 5-HT1A receptors in rat brain homogenate, labeled
Tomaszewski, Zbigniew,Johnson, Michael P.,Huang, Xuemei,Nichols, David E.
p. 2061 - 2064
(2007/10/02)
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